Patents by Inventor Mann-Jy Chen

Mann-Jy Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell lines capable of detecting low levels of cytokines in biological fluids
    Patent number: 5766865
    Abstract: A method of genetically engineering a cell line capable of detecting bioactive cytokines or growth factors is provided. Cells lines produced by this method and methods of using these cell lines to detect bioactive cytokines or growth factors in a biological fluid are also provided.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: June 16, 1998
    Assignee: Thomas Jefferson University
    Inventors: Mann-Jy Chen, Paul Chih-Hsueh Chen
  • Mutant tumor necrosis factor proteins
    Patent number: 5606023
    Abstract: Mutant tumor necrosis factor proteins which retain full or near full capability to bind to a TNFR-p75 receptor while retaining only a limited capability to bind a TNFR-p55 receptor are provided. Methods of inhibiting toxicity induced by tumor necrosis factor by treating cells or tissues having a tumor necrosis factor receptor with these mutant human tumor necrosis factor proteins are also provided. Pharmaceutical compositions and methods of inhibiting systemic tumor necrosis factor induced toxicity in a patient undergoing antitumor TNF-.alpha. therapy with these compositions are also provided.
    Type: Grant
    Filed: May 24, 1994
    Date of Patent: February 25, 1997
    Assignee: Thomas Jefferson University
    Inventors: Mann-Jy Chen, Irene T. Weber