Patents by Inventor Mann-Tchao Wang

Mann-Tchao Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Plasma-induced protein immobilization on polymeric surfaces
    Patent number: 5306768
    Abstract: The present invention relates to a method of immobilizing proteins on a polymeric matrix by means of plasma activation and an apparatus and process for the use of such material. The protein mixture is applied to the surface of the polymeric matrix with or without the addition of a crosslinking agent. It is then placed into a plasma generator, wherein the functional groups on both the protein and the matrix molecules are activated to form free radicals. Upon returning from their high energy state, the free radicals form covalent bonds between the proteins and between the protein and the polymeric matrix. Using this method, the proteins are nonspecifically immobilized on the surface of the polymeric matrix. The method can be utilized to immobilize proteins on the surfaces of polymeric membranes, polymeric beads, polymeric tubes and polymeric plates. The immobilized protein has high biological activity and stability.
    Type: Grant
    Filed: August 11, 1992
    Date of Patent: April 26, 1994
    Assignee: Industrial Technology Research Institute
    Inventors: Tien-Tsai Hsu, Mann-Tchao Wang, Kuang-Pin Hsiung, Ging H. Hsiue, Min-Shyan Sheu
  • Use of plasma to immobilize protein on polymeric surfaces
    Patent number: 5171779
    Abstract: The present invention relates to a method of immobilizing proteins on a polymeric matrix by means of plasma activation and an apparatus and process for the use of such material. The protein mixture is applied to the surface of the polymeric matrix with or without the addition of a crosslinking agent. It is then placed into a plasma generator, wherein the functional groups on both the protein and the matrix molecules are activated to form free radicals. Upon returning from their high energy state, the free radicals form covalent bonds between the proteins and between the protein and the polymeric matrix. Using this method, the proteins are nonspecifically immobilized on the surface of the polymeric matrix. The method can be utilized to immobilize proteins on the surfaces of polymeric membranes, polymeric beads, polymeric tubes and polymeric plates. The immobilized protein has high biological activity and stability.
    Type: Grant
    Filed: April 18, 1991
    Date of Patent: December 15, 1992
    Assignee: Industrial Technology Research Institute
    Inventors: Tien-Tsai Hsu, Mann-Tchao Wang, Kuang-Pin Hsiung, Ging H. Hsiue, Min-Shyan Sheu
  • Use of plasma to immobilize protein on polymeric surfaces
    Patent number: 5028657
    Abstract: The present invention relates to a method of immobilizing proteins on a polymeric matrix by means of plasma activation and an apparatus and process for the use of such material. The protein mixture is applied to the surface of the polymeric matrix with or without the addition of a crosslinking agent. If is then placed into a plasma generator, wherein the functional groups on both the protein and the matrix molecules are activated to form free radicals. Upon returning from their high energy state, the free radicals form covalent bonds between the proteins and between the protein and the polymeric matrix. Using this method, the proteins are nonspecifically immobilized on the surface of the polymeric matrix. The method can be utilized to immobilize proteins on the surface of polymeric membranes, polymeric beads, polymeric tubes and polymeric plates. The immobilized protein has high biological activity and stability.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: July 2, 1991
    Assignee: Industrial Research Technology Institute
    Inventors: Tien-Tsai Hsu, Mann-Tchao Wang, Kuang-Pin Hsiung, Ging H. Hsiue, Min-Shyan Sheu