Abstract: Described are computer-based methods and apparatuses, including computer program products, for designing assays. A database stores a set of user-selectable element data objects, a set of user-selectable operation data objects, and a set of validation rules for the one or more assays that can be used to determine whether an assay is valid. Data is received that is indicative of selecting, for a candidate assay specification, a first set of element data objects and a first set of operation data objects. The candidate assay specification is generated based on the received data. The candidate assay specification is validated. An assay data file is generated for the candidate assay specification that includes the first set of element data objects and the first set of operation data objects, such that the assay data file can be shared among a set of users.

Abstract: Described are computer-based methods and apparatuses, including computer program products, for designing assays. A database stores a set of user-selectable element data objects, a set of user-selectable operation data objects, and a set of validation rules for the one or more assays that can be used to determine whether an assay is valid. Data is received that is indicative of selecting, for a candidate assay specification, a first set of element data objects and a first set of operation data objects. The candidate assay specification is generated based on the received data. The candidate assay specification is validated. An assay data file is generated for the candidate assay specification that includes the first set of element data objects and the first set of operation data objects, such that the assay data file can be shared among a set of users.

Abstract: Described are computer-based methods and apparatuses, including computer program products, for designing assays. A database stores a set of user-selectable element data objects, a set of user-selectable operation data objects, and a set of validation rules for the one or more assays that can be used to determine whether an assay is valid. Data is received that is indicative of selecting, for a candidate assay specification, a first set of element data objects and a first set of operation data objects. The candidate assay specification is generated based on the received data. The candidate assay specification is validated. An assay data file is generated for the candidate assay specification that includes the first set of element data objects and the first set of operation data objects, such that the assay data file can be shared among a set of users.

Abstract: The present invention features use of evanescent field sensing to detect or evaluate unpurified, unlabeled analytes in raw samples. Capture molecules capable of binding to an analyte of interest can be immobilized to a sensing surface of an evanescent field sensor. The interaction between the analyte of interest in a raw sample and the immobilized capture molecules alters the refractive index at the sensing surface, thereby producing a detectable signal in the reflected light from the surface. Raw samples amenable to the present invention include, but are not limited to, cell lysates, tissue extracts, bodily fluid, or biologically-derived samples. Evanescent field sensors suitable for the present invention include, but are not limited to, grating-coupled waveguides.