Abstract: Systems and methods are provided for performing OCT vibrography based on the synchronization of components of the OCT vibrography system. An A-scan trigger is employed to synchronize the operation of the scanning subsystem that scans the sample beam and an acoustic stimulus source that generates an acoustic stimulus for vibrographic measurements. The acoustic stimulus source is controlled such that when the scanning subsystem dwells on an imaging line selected for vibrography measurements, the acoustic stimulus is generated over a plurality of A-scans and the phase of the acoustic stimulus is locked to the A-scan trigger, such that the phase of the acoustic stimulus is incrementally modified with each A-scan. The accumulation of the acoustic phase is therefore synchronized to the A-scan trigger. The synchronization, providing synchronized acoustic phase evolution during each acoustic phase waveform cycle, permits the use of the OCT vibrography system for simultaneous anatomical and functional imaging.

Abstract: Systems and methods are provided for performing OCT vibrography based on the synchronization of components of the OCT vibrography system. An A-scan trigger is employed to synchronize the operation of the scanning subsystem that scans the sample beam and an acoustic stimulus source that generates an acoustic stimulus for vibrographic measurements. The acoustic stimulus source is controlled such that when the scanning subsystem dwells on an imaging line selected for vibrography measurements, the acoustic stimulus is generated over a plurality of A-scans and the phase of the acoustic stimulus is locked to the A-scan trigger, such that the phase of the acoustic stimulus is incrementally modified with each A-scan. The accumulation of the acoustic phase is therefore synchronized to the A-scan trigger. The synchronization, providing synchronized acoustic phase evolution during each acoustic phase waveform cycle, permits the use of the OCT vibrography system for simultaneous anatomical and functional imaging.

Abstract: Among other things, in general, a piezoelectric actuator for use in a piezoelectric inertial hearing aid is disclosed. The actuator includes at least one bimorph having a top piezoelectric plate, a bottom piezoelectric plate, and a shim with holed ends that extends beyond the length of the plates for securing to bone across, e.g., the mastoid cavity. Actuators having two or morph bimorphs and kits containing the same are also disclosed.

Abstract: Systems and methods are provided for performing OCT vibrography based on the synchronization of components of the OCT vibrography system. An A-scan trigger is employed to synchronize the operation of the scanning subsystem that scans the sample beam and an acoustic stimulus source that generates an acoustic stimulus for vibrographic measurements. The acoustic stimulus source is controlled such that when the scanning subsystem dwells on an imaging line selected for vibrography measurements, the acoustic stimulus is generated over a plurality of A-scans and the phase of the acoustic stimulus is locked to the A-scan trigger, such that the phase of the acoustic stimulus is incrementally modified with each A-scan. The accumulation of the acoustic phase is therefore synchronized to the A-scan trigger. The synchronization, providing synchronized acoustic phase evolution during each acoustic phase waveform cycle, permits the use of the OCT vibrography system for simultaneous anatomical and functional imaging.

Abstract: Among other things, in general, methods of increasing transfer efficiency in a power link are described, as well as power links implementing such methods. Methods of dynamic charging are also described. Applications of such methods and power links include the charging of portable electronic devices as well as implantable medical devices.

Abstract: Among other things, in general, a piezoelectric actuator for use in a piezoelectric inertial hearing aid is disclosed. The actuator includes at least one bimorph having a top piezoelectric plate, a bottom piezoelectric plate, and a shim with holed ends that extends beyond the length of the plates for securing to bone across, e.g., the mastoid cavity. Actuators having two or morph bimorphs and kits containing the same are also disclosed.

Abstract: Among other things, in general, an acousto-mechanical transducer for the interconversion of electricity and acoustic waves is described. Methods are also described for the construction of such transducers.

Abstract: High-frequency ultrasound imaging can be performed with greater quality and suppressed grating lobes by using methods and systems for effectively reducing the temporal length of transmit grating lobe signals in received ultrasound echoes. Systems and methods are provided for improved high-frequency ultrasound imaging. In various aspects, the method of shortening the time domain of grating lobe signals comprises splitting an array of N transmit elements into K sub-apertures. In further aspects, the grating lobes are suppressed by performing signal processing of the shortened grating lobe signals. In certain aspects, the signal processing method comprises weighting the samples by a calculated phase coherence factor.

Abstract: Among other things, in general, an acousto-mechanical transducer for the interconversion of electricity and acoustic waves is described. Methods are also described for the construction of such transducers.

Abstract: High-frequency ultrasound imaging can be performed with greater quality and suppressed grating lobes by using methods and systems for effectively reducing the temporal length of transmit grating lobe signals in received ultrasound echoes. Systems and methods are provided for improved high-frequency ultrasound imaging. In various aspects, the method of shortening the time domain of grating lobe signals comprises splitting an array of N transmit elements into K sub-apertures. In further aspects, the grating lobes are suppressed by performing signal processing of the shortened grating lobe signals. In certain aspects, the signal processing method comprises weighting the samples by a calculated phase coherence factor.

Abstract: High-frequency ultrasound imaging can be performed with greater quality and suppressed grating lobes by using methods and systems for effectively reducing the temporal length of transmit grating lobe signals in received ultrasound echoes. Systems and methods are provided for improved high-frequency ultrasound imaging. In various aspects, the method of shortening the time domain of grating lobe signals comprises splitting an array of N transmit elements into K sub-apertures. In further aspects, the grating lobes are suppressed by performing signal processing of the shortened grating lobe signals. In certain aspects, the signal processing method comprises weighting the samples by a calculated phase coherence factor.

Abstract: An implantable bone-conduction hearing actuator based on a piezoelectric element, such as a unimorph or bimorph cantilever bender, is described. Unlike other implantable bone conduction hearing actuators, the device is subcutaneous and once implanted is entirely invisible. The device excites bending in bone through a local bending moment rather than the application of a point force as with conventional bone-anchored hearing aids.

Abstract: An implantable bone-conduction hearing actuator based on a piezoelectric element, such as a unimorph or bimorph cantilever bender, is described. Unlike other implantable bone conduction hearing actuators, the device is subcutaneous and once implanted is entirely invisible. The device excites bending in bone through a local bending moment rather than the application of a point force as with conventional bone-anchored hearing aids.

Abstract: Among other things, an audio device for transmission of sound information to a user's pinna is disclosed, the device having an actuator and a rigid backing attached to the actuator so as to form a gap without walls between the actuator and the backing.

Abstract: High-frequency ultrasound imaging can be performed with greater quality and suppressed grating lobes by using methods and systems for effectively reducing the temporal length of transmit grating lobe signals in received ultrasound echoes. Systems and methods are provided for improved high-frequency ultrasound imaging. In various aspects, the method of shortening the time domain of grating lobe signals comprises splitting an array of N transmit elements into K sub-apertures. In further aspects, the grating lobes are suppressed by performing signal processing of the shortened grating lobe signals. In certain aspects, the signal processing method comprises weighting the samples by a calculated phase coherence factor.

Abstract: An implantable bone-conduction hearing actuator based on a piezoelectric element, such as a unimorph or bimorph cantilever bender, is described. Unlike other implantable bone conduction hearing actuators, the device is subcutaneous and once implanted is entirely invisible. The device excites bending in bone through a local bending moment rather than the application of a point force as with conventional bone-anchored hearing aids.

Abstract: Disclosed is a method of treating or preventing hearing loss in a subject. The method comprises administering to the subject in need thereof, an adeno-associated viral expression vector encoding X-linked inhibitor of apoptosis protein (XIAP). The XIAP is positioned in the vector for expression in an inner ear organ, or associated neural structures, of the subject so as to treat or prevent the hearing loss. Also disclosed is a method of treating or preventing impaired balance.

Abstract: A self-retaining bone conduction hearing device having a sound processor (104) and a nonoccluding in-the-canal vibrating component (108) responsive to the sound processor and configured for non-surgical-implantation in a recipient's ear canal. Utilizing bone conduction eliminates the dependency on acoustic stimulation, thereby enabling the hearing device of the present invention to address a wider range of sound frequencies in conductive hearing loss.