Abstract: The present invention relates to novel SMAC mimetic peptidomimetics useful for the treatment of proliferative diseases including cancer in mammals The novel SMAC mimetics are prepared by incorporating (2S,5R)-5-(5-methylfuran-2-yl)pyrrolidine-2-carboxylic acid, a novel unnatural amino acid that imparts exclusively trans amide bond geometry favourable for target protein binding. Here, the novel SMAC mimetic molecule(s) not only show its efficacy in varied cancer types but also demonstrate in vitro and in vivo efficacy against therapy resistant cancer as a single agent. The novel SMAC mimetics disclosed in the present invention binds to BIR-2 and BIR-3 domains of the XIAP and exhibit high anti-proliferative activity against variety of mammalian cancer cell lines that include but not limited to chemotherapy and TRAIL resistant cell lines.

Abstract: Disclosed is a method for receiving streaming service data in a mobile communication system supporting a plurality of radio access interfaces, comprising the steps of: operating in a first mode for receiving, from a server, streaming service data through a first interface among the plurality of radio access interfaces; and determining a transition to a second mode for receiving the streaming service data by using at least two radio access interfaces according to a radio network currently being used in the first mode.

Abstract: Disclosed is a method for receiving streaming service data in a mobile communication system supporting a plurality of radio access interfaces, comprising the steps of: operating in a first mode for receiving, from a server, streaming service data through a first interface among the plurality of radio access interfaces; and determining a transition to a second mode for receiving the streaming service data by using at least two radio access interfaces according to a radio network currently being used in the first mode.

Abstract: Disclosed is a method for receiving streaming service data in a mobile communication system supporting a plurality of radio access interfaces, comprising the steps of: operating in a first mode for receiving, from a server, streaming service data through a first interface among the plurality of radio access interfaces; and determining a transition to a second mode for receiving the streaming service data by using at least two radio access interfaces according to a radio network currently being used in the first mode.

Abstract: Apparatuses and methods for performing congestion control in a transmission control protocol (TCP) environment in a wireless communication system are provided. At least one recovery session is opened a preset time after a time-out occurs in an original session, and whether link recovery is achieved after the at least one recovery session is opened and before a preset maximum wait time elapses is monitored. If the link recovery is achieved, a transmission speed is recovered according to a scenario corresponding to a time when the link recovery is achieved.

Abstract: The present disclosure relates to a device and method for transmitting and receiving data to and from a terminal in a wireless communication system. The method of operating the terminal in the wireless communication system may include the processes of comparing pre-stored domain name service (DNS) cache information with DNS inquiry information in a DNS inquiry if the DNS inquiry on a host is received from a uniform resource locator (URL) protocol handler, and transmitting internet protocol (IP) address information corresponding to the host to the URL protocol handler according to a compared result.

Abstract: In some embodiments, an asset integration service establishes a communication session between a design application and a client device for accessing source graphical assets from a web server executing a content management service. The integration service receives, during the communication session and via a design interface from the design application, a request to add a source graphical asset to a document displayed on the client device. The integration service retrieves, responsive to the request, a placement graphical asset that is a lower-resolution copy of the source graphical asset and updates the design interface to include the placement graphical asset. The integration service associates the placement graphical asset with a network link for accessing the source graphical asset via the content management service.

Abstract: The present disclosure relates to a pre-5th-Generation (5G) or 5G communication system to be provided for supporting higher data rates Beyond 4th-Generation (4G) communication system such as Long Term Evolution (LTE). A method for performing a handover by a terminal in a wireless communication system is provided. The method includes measuring a signal quality of a first network and determining whether the handover is required based on the signal quality of the first network, when the handover is determined to be required, communicating data through both a connection with the first network and a connection with a second network during a delay period and measuring the signal quality of the first network, when the delay period ends, determining whether to perform the handover based on the signal quality of the first network at a time when the delay period ends, and performing the handover.

Abstract: In some embodiments, an asset integration service establishes a communication session between a design application and a client device for accessing source graphical assets from a web server executing a content management service. The integration service receives, during the communication session and via a design interface from the design application, a request to add a source graphical asset to a document displayed on the client device. The integration service retrieves, responsive to the request, a placement graphical asset that is a lower-resolution copy of the source graphical asset and updates the design interface to include the placement graphical asset. The integration service associates the placement graphical asset with a network link for accessing the source graphical asset via the content management service.

Abstract: Disclosed is a method for receiving streaming service data in a mobile communication system supporting a plurality of radio access interfaces, comprising the steps of: operating in a first mode for receiving, from a server, streaming service data through a first interface among the plurality of radio access interfaces; and determining a transition to a second mode for receiving the streaming service data by using at least two radio access interfaces according to a radio network currently being used in the first mode.

Abstract: In one or more implementations, a digital medium environment includes at least one computing device. Systems and techniques are described herein for inserting linked text fragments in a document layout of a document. By supporting multiple linked text fragments within a text frame, of both constant content and variable content, content of an asset is inserted into a text fragment while preserving the styling attributes of the text frame. Thus, manual efforts associated with reapplying styling attributes are avoided, unlike systems that do not distinguish between text fragments with constant content and text fragments with variable content within a text frame. Furthermore, a user interface is generated that exposes metadata of assets and a document layout. Content of an asset exposed via the user interface, once selected, is inserted into the document layout and exposed as a tagged text fragment, indicating the content is linked.

Abstract: The present disclosure relates to a device and method for transmitting and receiving data to and from a terminal in a wireless communication system. The method of operating the terminal in the wireless communication system may include the processes of comparing pre-stored domain name service (DNS) cache information with DNS inquiry information in a DNS inquiry if the DNS inquiry on a host is received from a uniform resource locator (URL) protocol handler, and transmitting internet protocol (IP) address information corresponding to the host to the URL protocol handler according to a compared result.

Abstract: Apparatuses and methods for performing congestion control in a transmission control protocol (TCP) environment in a wireless communication system are provided. At least one recovery session is opened a preset time after a time-out occurs in an original session, and whether link recovery is achieved after the at least one recovery session is opened and before a preset maximum wait time elapses is monitored. If the link recovery is achieved, a transmission speed is recovered according to a scenario corresponding to a time when the link recovery is achieved.

Abstract: The present disclosure relates to a pre-5th-Generation (5G) or 5G communication system to be provided for supporting higher data rates Beyond 4th-Generation (4G) communication system such as Long Term Evolution (LTE). A method for performing a handover by a terminal in a wireless communication system is provided. The method includes measuring a signal quality of a first network and determining whether the handover is required based on the signal quality of the first network, when the handover is determined to be required, communicating data through both a connection with the first network and a connection with a second network during a delay period and measuring the signal quality of the first network, when the delay period ends, determining whether to perform the handover based on the signal quality of the first network at a time when the delay period ends, and performing the handover.

Abstract: Methods, systems, and computer-readable storage media for predicting advertiser keyword performance indicator values based on proximity of advertisers to one another are provided. A keyword is received from a first advertiser that has not previously bid on the keyword. Another advertiser that is similar to the first advertiser and has previously bid on the keyword is identified, and a predicted performance indicator value for the keyword is calculated for the first advertiser based upon an established performance indicator value of the keyword for the other advertiser. In this way, performance predictions for an advertiser desiring to bid on a keyword that is new to that advertiser may be calculated more accurately than traditional methods that do not take into account advertiser similarity.

Abstract: Methods, systems, and computer-readable storage media for predicting advertiser keyword performance indicator values based on proximity of advertisers to one another are provided. A keyword is received from a first advertiser that has not previously bid on the keyword. Another advertiser that is similar to the first advertiser and has previously bid on the keyword is identified, and a predicted performance indicator value for the keyword is calculated for the first advertiser based upon an established performance indicator value of the keyword for the other advertiser. In this way, performance predictions for an advertiser desiring to bid on a keyword that is new to that advertiser may be calculated more accurately than traditional methods that do not take into account advertiser similarity.

Abstract: There is provided, for an appliance having an operating shaft with a non-circular end section, the control assembly which includes a drive means, a coupling member, and mounting means for mounting the drive means non-rotatably on the appliance. The drive means has a low-speed, high-torque output shaft, and the coupling member has a first opening to receive the operating shaft and a second opening aligned with the first opening, the second opening being engagable with the output shaft. The first opening is complementary to the non-circular end section of the operating shaft, whereas the second opening and the output shaft are engagable to provide a lost-motion connection that allows the output shaft to engage the second opening over a wide angular range while still allowing the output shaft to engage and drive the coupling member.