Patents by Inventor Manoj K. PATEL

Manoj K. PATEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ADRENERGIC MECHANISMS OF AUDIOGENIC SEIZURE-INDUCED DEATH IN MOUSE MODEL OF SCN8A ENCEPHALOPATHY
    Publication number: 20240081300
    Abstract: Provided are compositions and methods for treating and/or preventing seizure-induced death in subjects in need thereof. In some embodiments, the methods include methods for inducing an audiogenic seizure and/or seizure-induced death, treating and/or preventing death associated with seizures in subjects, preventing sudden unexpected death in epilepsy (SUDEP) in subjects, preventing and/or reducing the risk of death in subjects having SCN8A gain-of-function mutations, preventing or reducing the risk of death associated with tonic seizures in subjects, and preventing or reducing the risk of death associated with epileptic seizures in subjects. Also provided are animals that have been modified to carry gain-of-function SCN8A mutations and methods for using the same to identify compounds that have activity in treating and/or preventing seizures and/or seizure-induced death in subjects.
    Type: Application
    Filed: January 12, 2022
    Publication date: March 14, 2024
    Applicant: University of Virginia Patent Foundation
    Inventors: Manoj K. Patel, Ian C. Wenker, Eric R. Wengert
  • COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS
    Publication number: 20220047554
    Abstract: The disclosure provides methods for treating a subject suffering from a disease associated with sodium channel activity. The method comprises administering to the subject a therapeutically effective amount of a compound according to Formula II or Formula III described in the specification, or a pharmaceutically acceptable salt, prodrug, tautomer, stereoisomer, hydrate, or solvate thereof.
    Type: Application
    Filed: June 25, 2021
    Publication date: February 17, 2022
    Inventors: Manoj K. Patel, Mirko Rivara
  • Compositions and methods for blocking sodium channels
    Patent number: 11090289
    Abstract: The disclosure provides methods for treating a subject suffering from a disease associated with sodium channel activity. The method comprises administering to the subject a therapeutically effective amount of a compound according to Formula II or Formula III described in the specification, or a pharmaceutically acceptable salt, prodrug, tautomer, stereoisomer, hydrate, or solvate thereof.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: August 17, 2021
    Assignee: University of Virginia Patent Foundation
    Inventors: Manoj K. Patel, Mirko Rivara
  • COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS
    Publication number: 20190365714
    Abstract: The disclosure provides methods for treating a subject suffering from a disease associated with sodium channel activity. The method comprises administering to the subject a therapeutically effective amount of a compound according to Formula II or Formula III described in the specification, or a pharmaceutically acceptable salt, prodrug, tautomer, stereoisomer, hydrate, or solvate thereof.
    Type: Application
    Filed: January 24, 2018
    Publication date: December 5, 2019
    Inventors: Manoj K. PATEL, Mirko RIVARA