Patents by Inventor Manoj Kumar Ramakrishna
Manoj Kumar Ramakrishna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11927503Abstract: The present invention relates to a computer implemented method for determining a weld integrity test result performed by a system configured to aseptically transferring cells to a container (BR), the method comprising welding (710) a vial to a connector to obtain a fluid-tight seal between the vial (V) and a connector (C), the connector being provided with a pair of conduits each having one end protruding through the connector and into the vial, sealing (720) an opposite end of one of the conduits, generating (730) a fluid pressure different to an ambient fluid pressure at an opposite end of the other conduit, measuring (740) a fluid pressure within at least one of the conduits, determining (750) a fluid pressure change based on the ambient pressure and the measured fluid pressure, determining (760) the weld integrity test result as pass or as fail based on the fluid pressure change.Type: GrantFiled: September 9, 2019Date of Patent: March 12, 2024Assignee: Cytiva Sweden ABInventors: Sameera Simha Hindupur, Manoj Kumar Ramakrishna, Andreas Castan, Swapnil Puranik, Klaus Gebauer
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Patent number: 11714935Abstract: Methods for selecting a filter for a filtration process are described. Input data is received, and based on the input data, one or more filter characteristics for each of a plurality of filter candidates for a filtration process are identified. Process parameters of the filtration process are identified. A computer-implemented simulation process of the filtration process for each of the plurality of filter candidates is performed, based on the identified process parameters and identified filter characteristics. One or more output characteristics of the filtration process are determined based on the simulation. A filter candidate of the plurality of filter candidates is selected based on the one or more output characteristics.Type: GrantFiled: December 17, 2018Date of Patent: August 1, 2023Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Manoj Kumar Ramakrishna, Swapnil Puranik, Mohammed Mehtab Khan
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Publication number: 20230094241Abstract: A parallel assembly of chromatography column modules connected in a rigid housing the assembly having one common assembly inlet and one common assembly outlet each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.Type: ApplicationFiled: November 17, 2022Publication date: March 30, 2023Inventors: Klaus Gebauer, Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Lofving
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Patent number: 11529570Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.Type: GrantFiled: November 24, 2020Date of Patent: December 20, 2022Assignee: Cytiva BioProcess R&D ABInventors: Klaus Gebauer, Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Lofving
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Publication number: 20220089349Abstract: A flexible bag (1; 101; 201) comprising a component (3; 103; 203) inside the bag, wherein said flexible bag comprises a receiving device (5; 105; 205) provided in a wall (7; 107; 207) of the flexible bag, wherein said component (3; 103; 203) and said receiving device (5; 105; 205) are configured for being connectable to each other for keeping the component substantially stationary within the flexible bag when so connected.Type: ApplicationFiled: March 19, 2019Publication date: March 24, 2022Inventors: Christopher Prem Kumar, Manoj Kumar Ramakrishna
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Publication number: 20220081671Abstract: Disclosed is an in-process cell monitoring device comprising: a flow channel having at least one inlet and at least one outlet exposeable to a cell culture; a microscope positionable to view the contents of a region of the channel; and a computer operable at least to count any cells in the region, providing a closed fluid circuit for cell monitoring. Disclosed also is a bioreactor including a cell culture volume, and an in-process cell monitoring device, said device comprising: a flow channel having at least one inlet and at least one outlet each in fluid communication with the volume, of sufficient cross-sectional area to allow fluids to drain from the inlet to the outlet; and a microscope positionable to view the contents of a region of the channel, and also A method for monitoring a cell culture including determining cell density.Type: ApplicationFiled: December 18, 2019Publication date: March 17, 2022Inventors: Swapnil Puranik, Manoj Kumar Ramakrishna, Haresh Patil
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Publication number: 20220034748Abstract: The present invention relates to a computer implemented method for determining a weld integrity test result performed by a system configured to aseptically transferring cells to a container (BR), the method comprising welding (710) a vial to a connector to obtain a fluid-tight seal between the vial (V) and a connector (C), the connector being provided with a pair of conduits each having one end protruding through the connector and into the vial, sealing (720) an opposite end of one of the conduits, generating (730) a fluid pressure different to an ambient fluid pressure at an opposite end of the other conduit, measuring (740) a fluid pressure within at least one of the conduits, determining (750) a fluid pressure change based on the ambient pressure and the measured fluid pressure, determining (760) the weld integrity test result as pass or as fail based on the fluid pressure change.Type: ApplicationFiled: September 9, 2019Publication date: February 3, 2022Inventors: Sameera Simha Hindupur, Manoj Kumar Ramakrishna, Andreas Castan, Swapnil Puranik, Klaus Gebauer
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Publication number: 20210077920Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.Type: ApplicationFiled: November 24, 2020Publication date: March 18, 2021Inventors: Klaus Gebauer, Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Lofving
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Publication number: 20210073439Abstract: Methods for selecting a filter for a filtration process are described. Input data is received, and based on the input data, one or more filter characteristics for each of a plurality of filter candidates for a filtration process are identified. Process parameters of the filtration process are identified. A computer-implemented simulation process of the filtration process for each of the plurality of filter candidates is performed, based on the identified process parameters and identified filter characteristics. One or more output characteristics of the filtration process are determined based on the simulation. A filter candidate of the plurality of filter candidates is selected based on the one or more output characteristics.Type: ApplicationFiled: December 17, 2018Publication date: March 11, 2021Inventors: Manoj Kumar Ramakrishna, Swapnil Puranik, Mohammed Mehtab Khan
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Patent number: 10940403Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.Type: GrantFiled: April 16, 2018Date of Patent: March 9, 2021Assignee: Cytiva BioProcess R&D ABInventors: Klaus Gebauer, Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Lofving
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Publication number: 20180229152Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.Type: ApplicationFiled: April 16, 2018Publication date: August 16, 2018Applicant: GE Healthcare BioProcess R&D ABInventors: Klaus Gebauer, Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Uselius
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Patent number: 9943781Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.Type: GrantFiled: June 1, 2011Date of Patent: April 17, 2018Assignee: GE HEALTHCARE BIOPROCESS R&D ABInventors: Klaus Gebauer, Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Uselius
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Patent number: 9278296Abstract: The present invention relates to methods for securing a distributor plate to a backing plate of a chromatography column without the need for releasable fixing means as screws or bolts. The invention also relates to chromatographic columns utilizing such methods. The method employs a negative pressure or vacuum that is generated internally within the column to affix the distributor to the backing plate.Type: GrantFiled: November 28, 2011Date of Patent: March 8, 2016Assignee: GE Healthcare Bio-Sciences ABInventors: Manoj Kumar Ramakrishna, Shashikanth Agnihotry
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Patent number: 9155979Abstract: A method for performing maintenance on a chromatography column (1; 41) comprising the steps of: a) when maintenance is required, detaching a detachable joint (7; 63) between a bottom plate (5; 53) of the chromatography column and a stand (3; 43) on which the chromatography column is provided; b) attaching an adaptor (15; 59) provided in the chromatography system to any part of the chromatography column (1; 41) making it possible to lift the bottom plate (5; 53) from the stand (3; 43) with the adaptor (15; 59); and c) raising the adaptor (15; 59) and thereby also the bottom plate (5; 53) such that maintenance can be performed under the bottom plate (5; 53).Type: GrantFiled: January 20, 2014Date of Patent: October 13, 2015Assignee: GE Healthcare Bio-Sciences ABInventors: Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Uselius
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Publication number: 20140131266Abstract: A method for performing maintenance on a chromatography column (1; 41) comprising the steps of: a) when maintenance is required, detaching a detachable joint (7; 63) between a bottom plate (5; 53) of the chromatography column and a stand (3; 43) on which the chromatography column is provided; b) attaching an adaptor (15; 59) provided in the chromatography system to any part of the chromatography column (1; 41) making it possible to lift the bottom plate (5; 53) from the stand (3; 43) with the adaptor (15; 59); and c) raising the adaptor (15; 59) and thereby also the bottom plate (5; 53) such that maintenance can be performed under the bottom plate (5; 53).Type: ApplicationFiled: January 20, 2014Publication date: May 15, 2014Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: MANOJ KUMAR RAMAKRISHNA, DANIEL SALOMONSSON, PER USELIUS
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Patent number: 8668829Abstract: A method for performing maintenance on a chromatography column (1; 41) comprising the steps of: a) when maintenance is required, detaching a detachable joint (7; 63) between a bottom plate (5; 53) of the chromatography column and a stand (3; 43) on which the chromatography column is provided; b) attaching an adaptor (15; 59) provided in the chromatography system to any part of the chromatography column (1; 41) making it possible to lift the bottom plate (5; 53) from the stand (3; 43) with the adaptor (15; 59); and c) raising the adaptor (15; 59) and thereby also the bottom plate (5; 53) such that maintenance can be performed under the bottom plate (5; 53).Type: GrantFiled: June 16, 2011Date of Patent: March 11, 2014Assignee: GE Healthcare Bio-Sciences ABInventors: Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Uselius
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Publication number: 20130240426Abstract: The present invention relates to methods for securing a distributor plate to a backing plate of a chromatography column without the need for releasable fixing means as screws or bolts. The invention also relates to chromatographic columns utilizing such methods. The method employs a negative pressure or vacuum that is generated internally within the column to affix the distributor to the backing plate.Type: ApplicationFiled: November 28, 2011Publication date: September 19, 2013Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Manoj Kumar Ramakrishna, Shashikanth Agnihotry
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Publication number: 20130087491Abstract: A method for performing maintenance on a chromatography column (1; 41) comprising the steps of: a) when maintenance is required, detaching a detachable joint (7; 63) between a bottom plate (5; 53) of the chromatography column and a stand (3; 43) on which the chromatography column is provided; b) attaching an adaptor (15; 59) provided in the chromatography system to any part of the chromatography column (1; 41) making it possible to lift the bottom plate (5; 53) from the stand (3; 43) with the adaptor (15; 59); and c) raising the adaptor (15; 59) and thereby also the bottom plate (5; 53) such that maintenance can be performed under the bottom plate (5; 53).Type: ApplicationFiled: June 16, 2011Publication date: April 11, 2013Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Uselius
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Publication number: 20130068671Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.Type: ApplicationFiled: June 1, 2011Publication date: March 21, 2013Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Klaus Gebauer, Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Uselius