Abstract: In various examples, techniques are described for detecting whether spoofing attacks are occurring using multiple sensors. Systems and methods are disclosed that include at least a first sensor having a first pose to capture a first perspective view of a user and a second sensor having a second pose to capture a second perspective view of the user. The first sensor and/or the second sensor may include an image sensor, a depth sensor, and/or the like. The systems and methods include a neural network that is configured to analyze first sensor data generated by the first sensor and second sensor data generated by the second sensor to determine whether a spoofing attack is occurring. The systems and methods may also perform one or more processes, such as facial recognition, based on whether the spoofing attack is occurring.