Abstract: Disclosed are methods and compositions for the treatment of an individual having neurodegeneration associated with Gaucher's disease and/or different forms of Parkinson's Disease. The disclosed methods and compositions include administering an inhibitor of the C5a pathway to an individual in need thereof, in an amount sufficient to delay onset of and/or alleviate neurodegeneration in the individual having, or suspected of having, Gaucher's disease. Inhibitors of the C5a pathway may include C5a Receptor (C5aR) inhibitors, antagonists of C5aR1, C5aR2, muteins of C5a, and combinations thereof.

Abstract: This disclosure describes methods of operating a leaf node device, such as a switch device, connected to a switch fabric of a network. The leaf node device receives, from another leaf node device via the switch fabric, an indication of a secure route to a host device. In response to receiving the indication of the secure route, the leaf node device creates or updates a routing entry for the host device in a routing information base of the leaf node device and creates or updates an entry for the host device in a Dynamic Host Configuration Protocol (DHCP) snoop database of the leaf node device. The leaf node may thereby communicate with the host device that is attached to the leaf node device as a result of moving from the other leaf node device.

Abstract: Systems, devices, and methods for detecting an Ethernet segment failure in an Ethernet virtual private network (EVPN) are described herein. An example method can include monitoring for failure of an Ethernet segment, establishing a bidirectional forwarding detection (BFD) session with a remote peer, and transmitting a BFD control packet to the remote peer over a network. The BFD control packet can include a notification of the failure of the Ethernet segment.

Abstract: Systems, devices, and methods for detecting an Ethernet segment failure in an Ethernet virtual private network (EVPN) are described herein. An example method can include monitoring for failure of an Ethernet segment, establishing a bidirectional forwarding detection (BFD) session with a remote peer, and transmitting a BFD control packet to the remote peer over a network. The BFD control packet can include a notification of the failure of the Ethernet segment.

Abstract: The present invention includes compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.

Abstract: The present invention provides a lactate biosensing strip comprising a working electrode and a reference electrode, the said two electrodes being deposited on an electrically insulated base support, the working electrode being formed by immobilizing an enzyme lactate oxidase and an electro mediator on an inorganic graphite matrix and the graphite layer being deposited on a silver layer and the reference electrode being formed by depositing silver chloride on an another silver layer.

Abstract: A system and method comprising automatically detecting signal activity associated with a frequency band having a plurality of channels for wireless communication, automatically identifying at least one channel having a low level of signal activity relative to one or more other channels associated with the frequency band, and selecting at least one of the identified channels for communicating over the frequency band.