Patents by Inventor Manojkumar Ramprasad Shukla
Manojkumar Ramprasad Shukla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230119316Abstract: Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, wherein, ring A, ring B, R1 to R4, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.Type: ApplicationFiled: December 27, 2020Publication date: April 20, 2023Inventors: Sanjay Pralhad Kurhade, Prathap Sreedharan Nair, Sachin Sethi, Manojkumar Ramprasad Shukla, Milind Dattatraya Sindkhedkar, Venkata P. Palle, Rajender Kumar Kamboj, Samiron Phukan, Pradeep Rangrao Patil, Sayyed Majid, Ramesh Phadatare, Navnath Walke, Vipul Pachpute, Balasaheb Gore, Vikas Tambe, Rohan Limaye, Avadhut Bhosale, Sachin Mahangare
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Publication number: 20230013778Abstract: Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, R1 to R5, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.Type: ApplicationFiled: November 28, 2020Publication date: January 19, 2023Inventors: Sachin Sethi, Prathap Sreedharan Nair, Manojkumar Ramprasad Shukla, Milind Dattatraya Sindkhedkar, Venkata P. Palle, Rajender Kumar Kamboj, Samiron Phukan, Pradeep Rangrao Patil, Ganesh Kakade, Nilesh Raghunath Khedkar, Dagadu Dube, Vikas Sitaram Tambe, Sudhakar Maruti Balgude, Pradip Balu Wagh
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Patent number: 9987249Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.Type: GrantFiled: January 26, 2017Date of Patent: June 5, 2018Assignee: LUPIN LIMITEDInventors: Manojkumar Ramprasad Shukla, Ankush Gangaram Sarde, Rajeshkumar Maganlal Loriya, Vipul Dilip Pachpute, Navnath Bajirao Walke, Talha Hussain Khan, Sanjeev Anant Kulkarni, Venkata P. Palle, Rajender Kumar Kamboj
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Patent number: 9944639Abstract: Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R1-R4, and n are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PI3K enzyme of a subject.Type: GrantFiled: July 1, 2015Date of Patent: April 17, 2018Assignee: Lupin LimitedInventors: Manojkumar Ramprasad Shukla, Nirmal Kumar Jana, Sachin Jaysing Mahangare, Prashant Popatrao Vidhate, Dipak Raychand Lagad, Anand Jagannath Tarage, Sanjeev Anant Kulkarni, Venkata P. Palle, Rajender Kumar Kamboj
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Publication number: 20170209410Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.Type: ApplicationFiled: January 26, 2017Publication date: July 27, 2017Inventors: Manojkumar Ramprasad SHUKLA, Ankush Gangaram SARDE, Rajeshkumar Maganlal LORIYA, Vipul Dilip PACHPUTE, Navnath Bajirao WALKE, Talha Hussain KHAN, Sanjeev Anant KULKARNI, Venkata P. PALLE, Rajender Kumar KAMBOJ
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Publication number: 20170137371Abstract: The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.Type: ApplicationFiled: January 31, 2017Publication date: May 18, 2017Inventors: Manojkumar Ramprasad Shukla, Vinod Dinkar Chaudhari, Ankush Gangaram Sarde, Ramesh Dattatraya Phadtare, Mahadeo Bhaskar Tryambake, Dronamraju Prameela, Sanjeev Anant Kulkarni, Rajender Kumar Kamboj, Venkata P. Palle
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Publication number: 20170137421Abstract: Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R1-R4, and n are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PI3K enzyme of a subject.Type: ApplicationFiled: July 1, 2015Publication date: May 18, 2017Applicant: Lupin LimitedInventors: Manojkumar Ramprasad Shukla, Nirmal Kumar Jana, Sachin Jaysing Mahangare, Prashant Popatrao Vidhate, Dipak Raychand Lagad, Anand Jagannath Tarage, Sanjeev Anant Kulkarni, Venkata P. Palle, Rajender Kumar Kamboj
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Patent number: 9598391Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.Type: GrantFiled: September 1, 2015Date of Patent: March 21, 2017Assignee: Lupin Atlantis Holdings SAInventors: Manojkumar Ramprasad Shukla, Ankush Gangaram Sarde, Rajeshkumar Maganlal Loriya, Vipul Dilip Pachpute, Navnath Bajirao Walke, Talha Hussain Khan, Sanjeev Anant Kulkarni, Venkata P. Palle, Rajender Kumar Kamboj
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Patent number: 9598371Abstract: The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.Type: GrantFiled: November 25, 2015Date of Patent: March 21, 2017Assignee: LUPIN ATLANTIS HOLDINGS SAInventors: Manojkumar Ramprasad Shukla, Vinod Dinkar Chaudhari, Ankush Gangaram Sarde, Ramesh Dattatraya Phadtare, Mahadeo Bhaskar Tryambake, Dronamraju Prameela, Sanjeev Kulkarni, Rajender Kumar Kamboj, Venkata P. Palle
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Patent number: 9464063Abstract: Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors of Formula (I).Type: GrantFiled: March 16, 2012Date of Patent: October 11, 2016Assignee: LUPIN ATLANTIS HOLDINGS SAInventors: Manojkumar Ramprasad Shukla, Sarde Gangaram Ankush, Pachpute Dilip Vipul, Majid Bashir Sayyed, Mahadeo Bhaskar Tryambake, Chetan Sanjay Pawar, Ganesh Navinchandra Gote, Sanjeev Anant Kulkarni, Venkata P. Palle, Rajender Kumar Kamboj
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Publication number: 20160250219Abstract: Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors of Formula (I).Type: ApplicationFiled: May 10, 2016Publication date: September 1, 2016Inventors: Manojkumar Ramprasad SHUKLA, Vinod Dinkar CHAUDHARI, Majid Bashir SAYYED, Ramesh Dattatraya PHADTARE, Navnath Bajirao WALKE, Sanjeev Anant KULKARNI, Venkata P. PALLE, Rajender Kumar KAMBOJ
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Patent number: 9382216Abstract: Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors of Formula (I).Type: GrantFiled: March 9, 2012Date of Patent: July 5, 2016Assignee: LUPIN LIMITEDInventors: Manojkumar Ramprasad Shukla, Vinod Dinkar Chaudhari, Majid Bashir Sayyed, Ramesh Dattatraya Phadtare, Navnath Bajirao Walke, Sanjeev Anant Kulkarni, Venkata P. Palle, Rajender Kumar Kamboj
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Publication number: 20160075655Abstract: The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.Type: ApplicationFiled: November 25, 2015Publication date: March 17, 2016Inventors: Manojkumar Ramprasad Shukla, Vinod Dinkar Chaudhari, Ankush Gangaram Sarde, Ramesh Dattatraya Phadtare, Mahadeo Bhaskar Tryambake, Dronamraju Prameela, Sanjeev Kulkarni, Rajender Kumar Kamboj, Venkata P. Palle
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Patent number: 9227919Abstract: The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.Type: GrantFiled: August 23, 2013Date of Patent: January 5, 2016Assignee: Lupin LimitedInventors: Manojkumar Ramprasad Shukla, Vinod Dinkar Chaudhari, Ankush Gangaram Sarde, Ramesh Dattatraya Phadtare, Mahadeo Bhaskar Tryambake, Dronamraju Prameela, Sanjeev Anant Kulkarni, Rajender Kumar Kamboj, Venkata P. Palle
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Publication number: 20150368222Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.Type: ApplicationFiled: September 1, 2015Publication date: December 24, 2015Inventors: Manojkumar Ramprasad SHUKLA, Ankush Gangaram SARDE, Rajeshkumar Maganlal LORIYA, Vipul Dilip PACHPUTE, Navnath Bajirao WALKE, Talha Hussain KHAN, Sanjeev Anant KULKARNI, Venkata P. PALLE, Rajender Kumar KAMBOJ
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Patent number: 9163001Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.Type: GrantFiled: February 22, 2013Date of Patent: October 20, 2015Assignee: LUPIN LIMITEDInventors: Manojkumar Ramprasad Shukla, Ankush Gangaram Sarde, Rajeshkumar Maganlal Loriya, Vipul Dilip Pachpute, Navnath Bajirao Walke, Talha Hussain Khan, Sanjeev Anant Kulkarni, Venkata P. Palle, Rajender Kumar Kamboj
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Publication number: 20150239827Abstract: The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.Type: ApplicationFiled: August 23, 2013Publication date: August 27, 2015Inventors: Manojkumar Ramprasad Shukla, Vinod Dinkar Chaudhari, Ankush Gangaram Sarde, Ramesh Dattatraya Phadtare, Mahadeo Bhaskar Tryambake, Dronamraju Prameela, Sanjeev Anant Kulkarni, Rajender Kumar Kamboj, Venkata P. Palle
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Publication number: 20150038546Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.Type: ApplicationFiled: February 22, 2013Publication date: February 5, 2015Inventors: Manojkumar Ramprasad Shukla, Ankush Gangaram Sarde, Rajeshkumar Maganlal Loriya, Vipul Dilip Pachpute, Navnath Bajirao Walke, Talha Hussain Khan, Sanjeev Anant Kulkarni, Venkata P. Palle, Rajender Kumar Kamboj
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Publication number: 20140018358Abstract: Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors of Formula (I).Type: ApplicationFiled: March 16, 2012Publication date: January 16, 2014Applicant: LUPIN LIMITEDInventors: Manojkumar Ramprasad Shukla, Sarde Gangaram Ankush, Pachpute Dilip Vipul, Majid Bashir Sayyed, Mahadeo Bhaskar Tryambake, Chetan Sanjay Pawar, Ganesh Navinchandra Gote, Sanjeev Anant Kulkarni, Venkata P. Palle, Rajender Kumar Kamboj
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Publication number: 20130345213Abstract: Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors of Formula (I).Type: ApplicationFiled: March 9, 2012Publication date: December 26, 2013Applicant: LUPIN LIMITEDInventors: Manojkumar Ramprasad Shukla, Vinod Dinkar Chaudhari, Majid Bashir Sayyed, Ramesh Dattatraya Phadtare, Navnath Bajirao Walke, Sanjeev Anant Kulkarni, Venkata P. Palle, Rajender Kumar Kamboj