Abstract: A treatment protocol system may include oral hygiene devices. Each oral hygiene device may detect a pH level within an opening of the user/animal, perform a comparison of the pH level within the opening of the user/animal with a threshold pH level, and selectively control a pH neutralization device based upon the comparison. The treatment protocol system also may have a server to receive a plurality of treatment parameters from each oral hygiene device. The include the pH level from each oral hygiene device, a neutralization agent use level from each oral hygiene device, and a health characteristic from an associated patient for each oral hygiene device. The server may be configured to generate a pH treatment protocol for the associated patient for each oral hygiene device based upon the treatment parameters.

Abstract: An oral hygiene device may include a housing having first and second ends, the second end configured to be inserted into an opening of a user/animal, and a processor carried by the housing. The oral hygiene device may include a pH sensor carried by the housing at the second end, and a pH neutralization device carried by the housing and configured to emit neutralization agent into the opening of the user/animal. The processor may be coupled to the pH sensor and the pH neutralization device. The processor may be configured to detect a pH level within the opening of the user/animal, compare the pH level within the opening of the user/animal with a threshold pH level, and selectively control the pH neutralization device based upon the comparison.