Abstract: Novel methods and uses for promoting sinonasal epithelial cell repair in a subject are described. These methods and uses are based on the administration of Rho/ROCK signaling pathway inhibitors, such as ROCK inhibitors. Subjects that may benefit from these methods and uses are those suffering from diseases/conditions associated with impaired nasal and paranasal sinus mucosa integrity and/or defective sinonasal epithelial repair and regeneration, such as rhinosinusitis (e.g., chronic rhinosinusitis, CRS). The Rho/ROCK signaling pathway inhibitors may be used alone or in combination with other active agents, such as steroids and/or antibiotics.