Abstract: Extended release or long-acting injectable compositions for use as in-situ forming implants are provided. The extended release injectable compositions and resulting long-acting in-situ forming implants include one or more drugs or active agents, a biocompatible solvent, a biodegradable polymer, and either an amphiphilic additive or a hydrophobic additive, or a combination of an amphiphilic additive and a hydrophobic additive. Such compositions are made to be injected in subjects in need of treatment to form in-situ formed implants within the subject, such in-situ formed implants having increased drug load and improved drug release for a longer duration. Methods of using such compositions, and treating subjects therewith are provided. Methods of making such compositions are also provided.

Abstract: The present disclosure is directed to a drug delivery system in which urate oxidase and metal-based nanoparticles for hydrogen peroxide degradation are loaded in a temperature-sensitive nanocarrier, and a pharmaceutical composition for treating hyperuricemia-related disease comprising the drug delivery system. In the drug delivery system of the present disclosure, urate oxidase and metal-based nanoparticles for hydrogen peroxide degradation are positioned close to each other, thereby effectively removing the toxic substance hydrogen peroxide (H2O2) generated during uric acid degradation. The drug delivery system of the present disclosure may be developed as an active ingredient of a drug for preventing or treating hyperuricemia-related disease.