Abstract: Described herein are methods for making a pharmaceutical composition for topical, transdermal or transmucosal delivery of a pharmaceutically active agent comprising combining (i) a first composition comprising or consisting of a pharmaceutically active agent and, optionally, a first volatile solvent and/or water, and (ii) a second composition comprising a resin, a second volatile solvent and 10-40% v/v water. Compositions made by these methods also are described, as are compositions comprising a pharmaceutically active agent, a volatile solvent, a resin and 10-40% (w/v) water, and containers containing such compositions or components thereof.