Patents by Inventor Mansukh C. Wani

Mansukh C. Wani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Camptothecin analogs having an E-ring ketone
    Patent number: 7071204
    Abstract: Camptothecin analogs having an E-ring ketone are effective anti tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I DNA cleavable complex.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: July 4, 2006
    Assignee: Research Triangle Institute
    Inventors: Michael A. Wall, Mansukh C. Wani, Govindarajan Manikumar, Monroe E. Wall
  • 7-substituted camptothecin and camptothecin analogs and methods for producing the same
    Patent number: 7067666
    Abstract: Methods of forming camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: June 27, 2006
    Assignee: Research Triangle Institute
    Inventors: Mansukh C. Wani, Govindarajan Manikumar, Michael A. Wall, Monroe E. Wall
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6864248
    Abstract: An androgenic steroid compound of the formula: wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: March 8, 2005
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • 7-Substituted camptothecin and camptothecin analogs and methods for producing the same
    Publication number: 20040266803
    Abstract: Methods of forming camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
    Type: Application
    Filed: June 27, 2003
    Publication date: December 30, 2004
    Applicant: Research Triangle Insitute
    Inventors: Mansukh C. Wani, Govindarajan Manikumar, Monroe E. Wall, Michael A. Wall
  • Camptothecin analogs having an E-ring ketone
    Publication number: 20040266804
    Abstract: Camptothecin analogs having an E-ring ketone are effective anti tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I DNA cleavable complex.
    Type: Application
    Filed: June 30, 2003
    Publication date: December 30, 2004
    Applicant: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani, Govindarajan Manikumar, Michael A. Wall
  • Camptothecin compounds with a thioether group
    Patent number: 6825206
    Abstract: Camptothecin compounds which are effective anti-tumor compounds are disclosed. These conjugates inhibit the enzyme topoisomerase I and enhance the stability of the topoisomerase I-DNA cleavable complex.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: November 30, 2004
    Assignees: Research Triangle Institute, Duke University, National Institutes of Health
    Inventors: Michael P. Gamcsik, David J. Adams, O. Michael Colvin, Monroe E. Wall, Mansukh C. Wani, Govindarajan Manikumar, Yves Pommier
  • Androgenic steroid compounds and a method of making and using the same
    Publication number: 20040097477
    Abstract: An androgenic steroid compound of the formula: 1
    Type: Application
    Filed: November 4, 2003
    Publication date: May 20, 2004
    Applicant: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6670352
    Abstract: An androgenic steroid compound of the formula: wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: December 30, 2003
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • Androgenic steroid compounds and a method of making and using the same
    Publication number: 20020103177
    Abstract: An androgenic steroid compound of the formula: 1
    Type: Application
    Filed: January 22, 2002
    Publication date: August 1, 2002
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6369047
    Abstract: An androgenic steroid compound of the formula: wherein: X Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: April 9, 2002
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • ANDROGENIC STEROID COMPOUNDS AND A METHOD OF MAKING AND USING THE SAME
    Publication number: 20020002156
    Abstract: An androgenic steroid compound of the formula: 1
    Type: Application
    Filed: June 9, 1999
    Publication date: January 3, 2002
    Inventors: C. EDGAR COOK, JOHN A. KEPLER, YUE-WEI LEE, MANSUKH C. WANI
  • Camptothecin &bgr;-alanine esters with topoisomerase I inhibition
    Patent number: 6288072
    Abstract: &bgr;-Alanine esters of camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
    Type: Grant
    Filed: December 29, 1999
    Date of Patent: September 11, 2001
    Inventors: Monroe E. Wall, Mansukh C. Wani, Govindarajan Manikumar, Neelakantan Balasubramanian, Dolatrai Vyas
  • 10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition
    Patent number: 6268375
    Abstract: Camptothecin compounds having a C10 11 O—(CF2)nO group where n is 1 or 2 are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
    Type: Grant
    Filed: December 29, 1999
    Date of Patent: July 31, 2001
    Assignees: Research Triangle Institute, Bristol-Myers Squibb Company
    Inventors: Monroe E. Wall, Mansukh C. Wani, Govindarajan Manikumar, Neelakantan Balasubramanian, Dolatrai Vyas
  • Water-soluble esters of camptothecin compounds
    Patent number: 6040313
    Abstract: Non-toxic camptothecin prodrugs are prepared by esterifying the 20-position hydroxyl group of camptothecin derivatives.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: March 21, 2000
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani
  • Camptothecin compounds with combined topoisomarase I inhibition and DNA alkylation properties
    Patent number: 5985888
    Abstract: Camptothecin compounds having a --CH.sub.2 --L group are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and DNA of associated topoisomerase I-DNA complexes.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: November 16, 1999
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 5952319
    Abstract: An androgenic steroid compound of the formula: ##STR1## wherein: X, Y, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.5 and R.sup.6 are as defined herein.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: September 14, 1999
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • Hexahydroindenopyridine compounds having antispermatogenic activity
    Patent number: 5952336
    Abstract: Hexahydroindenopyridine compounds having the following formula and relative stereochemistry ##STR1## where R.sup.1 is C.sub.1-6 alkyl; R.sup.2 is hydrogen or C.sub.1-6 alkyl; R.sup.3 is carboxyl or a group which is metabolized to a carboxyl group under mammalian physiological conditions; R.sup.4 is halogen; mixtures of said compound and acid addition salts thereof exhibit potent antispermatogenic activity and are useful in a method of inhibiting spermatogenesis in mammals.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: September 14, 1999
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, Joseph M. Jump, Pingsheng Zhang, John R. Stephens, Patricia A. Fail, Yue-Wei Lee, Mansukh C. Wani
  • Camptothecin compounds with combined topoisomerase I inhibition and DNA alkylation properties
    Patent number: 5932588
    Abstract: Camptothecin compounds having a --CH.sub.2 --L group are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and DNA of associated topoisomerase I-DNA complexes.
    Type: Grant
    Filed: October 8, 1997
    Date of Patent: August 3, 1999
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani
  • Water-soluble esters of camptothecin compounds
    Patent number: 5916896
    Abstract: Non-toxic camptothecin prodrugs are prepared by esterifying the 20-position hydroxyl group of camptothecin derivatives.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: June 29, 1999
    Assignee: Research Triange Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani
  • Water-soluble esters of camptothecin compounds
    Patent number: 5646159
    Abstract: Non-toxic camptothecin prodrugs are prepared by esterifying the 20-position hydroxyl group of camptothecin derivatives.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: July 8, 1997
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani