Patents by Inventor Mansuo Lu Hayashi

Mansuo Lu Hayashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination therapy
    Patent number: 11839654
    Abstract: The present invention provides a method of treating a tau-mediated cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of an anti-Tau antibody and an effective amount of an OGA inhibitor.
    Type: Grant
    Filed: January 5, 2021
    Date of Patent: December 12, 2023
    Assignee: Eli Lilly and Company
    Inventors: Mansuo Lu Hayashi, Michael Carl Irizarry, Hugh Nuthall
  • Anti-Alpha-Synuclein Antibodies and Uses Thereof
    Publication number: 20220048982
    Abstract: The present invention relates to anti-alpha-synuclein antibodies, and uses thereof for treating diseases such as Parkinson's disease.
    Type: Application
    Filed: December 9, 2019
    Publication date: February 17, 2022
    Applicant: Eli Lilly and Company
    Inventors: Johnny Eugene CROY, Mansuo Lu HAYASHI, Jirong LU, Bo MA, Ying TANG
  • COMBINATION THERAPY
    Publication number: 20210301003
    Abstract: A method of treating a cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of an anti-N3pGlu Abeta antibody, an anti-Abeta antibody, or an antibody fragment that binds Amyloid beta and is covalently attached to a polyethylene glycol molecule, in combination with an effective amount of an anti-Tau antibody.
    Type: Application
    Filed: March 24, 2021
    Publication date: September 30, 2021
    Inventors: Mansuo Lu Hayashi, Michael Carl Irizarry
  • Combination Therapy
    Publication number: 20210121565
    Abstract: The present invention provides a method of treating a tau-mediated cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of an anti-Tau antibody and an effective amount of an OGA inhibitor.
    Type: Application
    Filed: January 5, 2021
    Publication date: April 29, 2021
    Inventors: Mansuo Lu Hayashi, Michael Carl Irizarry, Hugh Nuthall
  • Combination therapy
    Patent number: 10988529
    Abstract: A method of treating a cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of an anti-N3pGlu Abeta antibody, an anti-Abeta antibody, or an antibody fragment that binds Amyloid beta and is covalently attached to a polyethylene glycol molecule, in combination with an effective amount of an anti-Tau antibody.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: April 27, 2021
    Assignee: Eli Lilly and Company
    Inventors: Mansuo Lu Hayashi, Michael Carl Irizarry
  • DNA molecules encoding antibodies to tau and methods of making thereof
    Patent number: 10808027
    Abstract: Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including Alzheimer's disease, Progressive Supranuclear Palsy and Pick's disease.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: October 20, 2020
    Assignee: Eli Lilly and Company
    Inventors: Mansuo Lu Hayashi, Jirong Lu, David Driver, Alberto Alvarado
  • COMBINATION THERAPY
    Publication number: 20190161539
    Abstract: A method of treating a cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of an anti-N3pGlu Abeta antibody, an anti-Abeta antibody, or an antibody fragment that binds Amyloid beta and is covalently attached to a polyethylene glycol molecule, in combination with an effective amount of an anti-Tau antibody.
    Type: Application
    Filed: August 3, 2017
    Publication date: May 30, 2019
    Inventors: Mansuo Lu Hayashi, Michael Carl Irizarry
  • ANTIBODIES TO TAU AND USES THEREOF
    Publication number: 20180265577
    Abstract: Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including Alzheimer's disease, Progressive Supranuclear Palsy and Pick's disease.
    Type: Application
    Filed: May 31, 2018
    Publication date: September 20, 2018
    Inventors: Mansuo Lu Hayashi, Jirong Lu, David Driver, Alberto Alvarado
  • Antibodies to tau and methods of treatment therewith
    Patent number: 10011653
    Abstract: Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including Alzheimer's disease, Progressive Supranuclear Palsy and Pick's disease.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: July 3, 2018
    Assignee: Eli Lilly and Company
    Inventors: Mansuo Lu Hayashi, Jirong Lu, David Driver, Alberto Alvarado
  • ANTIBODIES TO TAU AND USES THEREOF
    Publication number: 20170107278
    Abstract: Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including Alzheimer's disease, Progressive Supranuclear Palsy and Pick's disease.
    Type: Application
    Filed: November 10, 2016
    Publication date: April 20, 2017
    Inventors: Mansuo Lu Hayashi, Jirong Lu, David Driver, Alberto Alvarado
  • Antibodies to tau and uses thereof
    Patent number: 9527909
    Abstract: Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including Alzheimer's disease, Progressive Supranuclear Palsy and Pick's disease.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: December 27, 2016
    Assignee: Eli Lilly and Company
    Inventors: Mansuo Lu Hayashi, Jirong Lu, David Driver, Alberto Alvarado
  • ANTIBODIES TO TAU AND USES THEREOF
    Publication number: 20160251420
    Abstract: Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including Alzheimer's disease, Progressive Supranuclear Palsy and Pick's disease.
    Type: Application
    Filed: February 18, 2016
    Publication date: September 1, 2016
    Inventors: Mansuo Lu Hayashi, Jirong Lu, David Driver, Alberto Alvarado