Patents by Inventor Mantripragada Bhima Sankaram

Mantripragada Bhima Sankaram has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biodegradable Compositions for the controlled release of encapsulated substances
    Publication number: 20010048945
    Abstract: Pharmaceutical compositions that enable the release of a physiologically active substance over a prolonged period of time following administration to a patient are described. The pharmaceutical compositions are provided by encapsulation of a physiologically active substance into a matrix comprising biodegradable polymers and lipids. The rate of release of the physiologically active substance from the pharmaceutical composition is controlled by varying the ratio of the polymer to the lipid. The compositions can be stored in an aqueous suspension or as a solid dosage form. The physiologically active substances include small molecules, peptides, proteins, nucleic acids and vaccines. The biodegradable polymers include homopolymers, or random or block copolymers. The lipids include phospholipids, cholesterol and glycerides.
    Type: Application
    Filed: May 17, 2001
    Publication date: December 6, 2001
    Applicant: SkyePharma, Inc., a California corporation
    Inventor: Mantripragada Bhima Sankaram
  • Method for producing liposomes with increased percent of compound encapsulated
    Patent number: 6241999
    Abstract: The efficiency of encapsulating a drug into a liposomal formulation is increased by use of a lipid having a carbon chain containing from about 13 to about 28 carbons during preparation of the liposomes. Preferably the liposomes are multivesicular liposomes.
    Type: Grant
    Filed: December 6, 1999
    Date of Patent: June 5, 2001
    Assignee: SkyePharma, Inc.
    Inventors: Qiang Ye, Mantripragada Bhima Sankaram
  • Method for producing liposomes with increased percent of compound encapsulated
    Patent number: 6193998
    Abstract: The efficiency of encapsulating a drug into a liposomal formulation is increased by use of a lipid having a carbon chain containing from about 13 to about 28 carbons during preparation of the liposomes. Preferably the liposomes are multivesicular liposomes.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: February 27, 2001
    Assignee: SkyePharma Inc.
    Inventors: Qiang Ye, Mantripragada Bhima Sankaram
  • Method for producing liposomes with increased percent of compound encapsulated
    Patent number: 6171613
    Abstract: The efficiency of encapsulating a drug into a liposomal formulation is increased by use of a lipid having a carbon chain containing from about 13 to about 28 carbons during preparation of the liposomes. Preferably the liposomes are multivesicular liposomes.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: January 9, 2001
    Assignee: SkyePharma Inc.
    Inventors: Qiang Ye, Mantripragada Bhima Sankaram
  • Multivesicular liposomes with controlled release of encapsulated biologically active substances
    Patent number: 6132766
    Abstract: A multivesicular liposome composition containing at least one acid other than a hydrohalic acid and at least one biologically active substance, the vesicles having defined size distribution, adjustable average size, internal chamber size and number, provides a controlled release rate of the biologically active substance from the composition. A process for making the composition features addition of a non-hydrohalic acid effective to sustain and control the rate of release of an encapsulated biologically active substance from the vesicles at therapeutic levels in vivo.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: October 17, 2000
    Assignee: SkyePharma Inc.
    Inventors: Mantripragada Bhima Sankaram, Sinil Kim
  • Method for producing liposomes with increased percent of compound encapsulated
    Patent number: 5997899
    Abstract: The efficiency of encapsulating a drug into a liposomal formulation is increased by use of a lipid having a carbon chain containing from about 13 to about 28 carbons during preparation of the liposomes. Preferably the liposomes are multivesicular liposomes.
    Type: Grant
    Filed: October 1, 1996
    Date of Patent: December 7, 1999
    Assignee: SkyePharma Inc.
    Inventors: Qiang Ye, Mantripragada Bhima Sankaram
  • Multivescular liposomes with controlled release of encapsulated biologically active substances
    Patent number: 5766627
    Abstract: A multivesicular liposome composition containing at least one acid other than a hydrohalic acid and at least one biologically active substance, the vesicles having defined size distribution, adjustable average size, internal chamber size and number, provides a controlled release rate of the biologically active substance from the composition. A process for making the composition features addition of a non-hydrohalic acid effective to sustain and control the rate of release of an encapsulated biologically active substance from the vesicles at therapeutic levels in vivo.
    Type: Grant
    Filed: May 23, 1997
    Date of Patent: June 16, 1998
    Assignee: Depotech
    Inventors: Mantripragada Bhima Sankaram, Sinil Kim