Patents by Inventor Manuel Alvarez

Manuel Alvarez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9522833
    Abstract: There is described a number of biological nutrient removal processes including Anammox Process, Biological Phosphorus Removal (BPR), Partial Nitrification, Full Nitrification, Partial Denitrification, Full Denitrification and Denitrification via BPR taking place in a Simultaneous Treatment of Anammox/PAOs Reactor (STAR) coupled with an Anaerobic Lateral Unit (ALU). In one aspect, there is a wastewater treatment system comprises a bioreactor having three consecutive stages: and an anaerobic lateral unit (ALU) coupled to the bioreactor; the bioreactor and ALU are configured to conduct biological removal of nutrients from the wastewater using a plurality of biological processes simultaneously. The three consecutive stages of the bioreactor comprise two Anoxic stages configured consecutively followed by one Aerobic stage. The stages may be oriented vertically and use gravity for fluid flow.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: December 20, 2016
    Inventors: Manuel Alvarez-Cuenca, Maryam Reza
  • Publication number: 20160137258
    Abstract: The invention provides a vehicle drivable in use by a person walking or running whilst seated comprising: a frame; a large diameter front wheel non-steerable with respect to the frame, a seat for supporting a user's weight whilst walking or running, the frame configured to carry the seat suspended on the front wheel, a small diameter, steerable rear wheel journalled to the frame at a steering pivot axis, the seat being rotatable forwardly with respect to the front wheel and comprising a seat base for supporting a user and further comprising a backrest for engaging the user's back in use. The large front wheel may be of approximate diameter of a user's leg (typically an adult human), thus the large front wheel may be of similar size to a bicycle wheel for the user.
    Type: Application
    Filed: May 30, 2014
    Publication date: May 19, 2016
    Inventors: Manuel ALVAREZ-ICAZA, Veronica VARGAS
  • Publication number: 20150082438
    Abstract: Disclosed embodiments include a distributed system and server for detecting changes to web pages comprises (a) a Web Change Detection (WCD) server connected to the network, and (b) one or more WCD agents stored on the WCD server configured to be executed directly on a web browser to detect web page changes. The WCD comprises (a) an agent storage module configured to store the WCD agents, (b) a WCD repository to store a WCD information regarding the web pages in the server memory, and (c) a WCD changes detector configured for receiving information sent by the WCD agents and detecting changes on the web pages. The WCD system relies on the web users accessing sites to collaboratively detect the changes on the web pages, eliminating the need for crawler estimates of web-page changes.
    Type: Application
    Filed: November 22, 2014
    Publication date: March 19, 2015
    Applicant: UNIVERSIDADE DA CORUÑA
    Inventors: VICTOR MANUEL PRIETO ALVAREZ, MANUEL ALVAREZ DIAZ, FIDEL CACHEDA SEIJO, VICTOR CARNEIRO DIAZ
  • Publication number: 20150069660
    Abstract: The improved mold assembly for cultured marble molding is provided. The mold assembly can comprise a male mold portion and a female mold portion. The assembly can further comprise a molding tool. The molding tool can have a side wall having an upper curved portion and a lower curved portion. The molding tool can have a bowl portion and an apron portion spaced from the bowl portion by a gap. The molding tool can be constructed from a flexible and/or soft material. The molding tool can facilitate molding of a countertop having at least one seamless curved edge and/or an at least partially seamless sink portion.
    Type: Application
    Filed: July 28, 2014
    Publication date: March 12, 2015
    Inventors: Damian J. Le Duff, Manuel Alvarez
  • Publication number: 20140346109
    Abstract: There is described a number of biological nutrient removal processes including Anammox Process, Biological Phosphorus Removal (BPR), Partial Nitrification, Full Nitrification, Partial Denitrification, Full Denitrification and Denitrification via BPR taking place in a Simultaneous Treatment of Anammox/PAOs Reactor (STAR) coupled with an Anaerobic Lateral Unit (ALU). In one aspect, there is a wastewater treatment system comprises a bioreactor having three consecutive stages: and an anaerobic lateral unit (ALU) coupled to the bioreactor; the bioreactor and A LU are configured to conduct biological removal of nutrients from the wastewater using a plurality of biological processes simultaneously. The three consecutive stages of the bioreactor comprise two Anoxic stages configured consecutively followed by one Aerobic stage. The stages may be oriented vertically and use gravity for fluid flow.
    Type: Application
    Filed: May 23, 2014
    Publication date: November 27, 2014
    Inventors: Manuel Alvarez-Cuenca, Maryam Reza
  • Patent number: 8697093
    Abstract: The present invention relates to the field of biotechnology applied to human health. The invention describes a vaccine vehicle which toxins from eukaryotic organisms are encapsulated in liposomes with multiple lipid layers, obtained by means of the process of dehydration/rehydration, the lipid composition of which is dipalmitoylphosphatidylcholine:cholesterol in a molar ration of 1:1, which are designed for subcutaneous or intramuscular administration. These compositions do not require the use of other adjuvants. The compositions described allow modulation of the specific CTL immune response to one or more antigens co-encapsulated in the liposomes that containing the toxin. The vaccine vehicle of the present invention presents advantages as compared with others described in the prior art owning to the robust and functional nature of the immune response induced and also the immunomodulating properties thereof.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: April 15, 2014
    Assignee: Centro De Immunologia Molecular
    Inventors: Maria Eliana Lanio Ruiz, Luis Enrique Fernández Molina, Rady Judith Laboroe Quintana, Yoelys Cruz Leal, Maria del Carmen Luzardo Lorenzo, Circe Mesa Pardillo, Carlos Manuel Alvarez Valcárcel, Isabel Fabiola Pazos Santos, Mayra Tejuca Martínez, Aisel Valle Garay, Maria Eugenia Alonso Biosca, Liem Canet Santos
  • Patent number: 8585900
    Abstract: In accordance with particular process, method and system aspects there is provided a biological manner of treating water/wastewater. Treatment is undertaken in bioreactor configured to treat the water/wastewater through a first process of denitrification followed by a second process of biological phosphorus removal. The bioreactor may be defined by multiple stages arranged in compact vertical alignment, for example, to reduce a footprint of the bioreactor and to feed the water/wastewater between the stages using gravity. The stages may comprise, in order, a Deaeration stage, an Anoxic stage, an Anaerobic stage, and an Aerobic stage. Continuous vacuum operation in the Deaeration stage enhances the physical removal of oxygen and other dissolved gases.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: November 19, 2013
    Inventors: Manuel Alvarez-Cuenca, Maryam Reza
  • Publication number: 20130149376
    Abstract: The current invention relates to the field of Biotechnology applied to human health. Here it is described a vaccine vehicle wherein toxins from eukaryotic organisms are encapsulated into multilamellar vesicles obtained by the dehydration-rehydration procedure whose lipidic composition is dipalmitoylphosphatidylcholine:cholesterol in a 1:1 molar ratio for subcutaneous or intramuscular administration. These compositions do not require the use of other adjuvants. The disclosed compositions allow modulation of CTL-specific immune response against one or several antigens co-encapsulated into toxin-containing liposomes. The vaccinal vehicle of the present invention shows advantages over others disclosed by the previous art due to the robustness and functionality of the induced immune response as well as its immunomodulating properties.
    Type: Application
    Filed: July 5, 2011
    Publication date: June 13, 2013
    Applicant: CENTRO DE INMUNOLOGIA MOLECULAR
    Inventors: Maria Eliana Lanio Ruiz, Luis Enrique Fernández Molina, Rady Judith Laboroe Quintana, Yoelys Cruz Leal, Maria del Carmen Luzardo Lorenzo, Circe Mesa Pardillo, Carlos Manuel Alvarez Valcàrcel, Isabel Fabiola Pazos Santos, Mayra Tejuca Martínez, Aisel Valle Garay, María Eugenia Alonso Biosca, Liem Canet Santos
  • Patent number: 8460537
    Abstract: A method for determining an analyte concentration in blood is described that reduces the effects of hematocrit using a test strip attached to a test meter. The test strip includes a working electrode and a reference electrode. The test meter applies a test voltage between the working electrode and the reference electrode. After a user applies a blood sample containing an analyte onto the test strip, the test meter measures a plurality of test currents for a test time interval.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: June 11, 2013
    Assignee: LifeScan Scotland Limited
    Inventors: Stephen Patrick Blythe, Marco F Cardosi, Leanne Mills, Manuel Alvarez-Icaza, Emma Vanessa Jayne Day, Richard Michael Day, Christopher Philip Leach
  • Patent number: 8409412
    Abstract: The invention provides an enzyme ink useful in test strips that provides a test strip bias, at the low and high glucose ends, falling within a desired target range. The ink of the invention permits an improved method for the production of single calibration code strip lots with good yields.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: April 2, 2013
    Assignee: LifeScan Scotland, Ltd.
    Inventors: Gary Young, Michael O'Connell, Ian McArthur, Alan McNeilage, Nick Phippen, Manuel Alvarez-Icaza
  • Publication number: 20120261258
    Abstract: Various embodiments of a technique in which test strip lots can be prepared without requiring a user to input any calibration information before performing a test measurement with a test strip from the test strip lots. In a first aspect, a method of manufacturing a plurality of test strips by adjusting amount of mediators and working electrode area is described. In another aspect, a method of preparing a reagent ink by adjusting the density of the reagent ink to substantially match a target density is described. In a further aspect, a method using a high numerical Shores Hardness squeegee in conjunction with high pressure is provided. In a further aspect, a method of performing an analyte measurement with a test meter, the test meter being configured to not receive a calibration input, and where the test strip manufactured to any one of the methods or techniques described and illustrated herein.
    Type: Application
    Filed: June 14, 2012
    Publication date: October 18, 2012
    Inventors: Gavin MACFIE, Robert Marshall, Manuel Alvarez-Icaza, Kevin Delaney, Keith Duffus, Tim Jarvis, Martin Lamacka, Nicholas Phippen, Robert Russell
  • Publication number: 20120199498
    Abstract: An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes an electrically-insulating substrate, at least one working electrode disposed on the electrically-insulating substrate and a graded enzymatic reagent layer disposed on the at least one working electrode. The graded enzymatic reagent layer includes an upper reaction grade that contains an enzyme. The graded enzymatic layer also has a lower spacer grade devoid of the enzyme, the lower spacer grade disposed between the upper reaction grade and the working electrode such that the upper reaction grade is spaced equidistant from the working electrode by the lower spacer grade by a predetermined distance during use of the electrochemical-based analytical test strip.
    Type: Application
    Filed: February 7, 2011
    Publication date: August 9, 2012
    Inventors: Manuel Alvarez-Icaza, Alan McNeilage, Zuifang Liu, Damian Baskeyfield
  • Publication number: 20120104718
    Abstract: A tubular side bar and mounting system may have a plurality of separate components that allow the tubular side bar to be mounted to a truck or other vehicle by one person. The system may include one or more mounting brackets that can be mounted to the truck before mounting a tubular side bar. After the mounting brackets are secured to the truck, the tubular side bar is then mounted to the mounting brackets. In this manner, a single person may install the tubular side bar to the truck. To attach the mounting bracket to the tubular side bar, the mounting bracket may be clamped along any point of an elongate channel formed in the tubular side bar to account for trucks with different mounting places. One configuration of the running board can be mounted to different trucks having different mounting places configuration.
    Type: Application
    Filed: October 29, 2010
    Publication date: May 3, 2012
    Inventors: Manuel Alvarez, Rigoberto Gonzalez, Alberto Montoya, Felipe Ceja
  • Publication number: 20120043204
    Abstract: The invention provides an enzyme ink useful in test strips that provides a test strip bias, at the low and high glucose ends, falling within a desired target range. The ink of the invention permits an improved method for the production of single calibration code strip lots with good yields.
    Type: Application
    Filed: August 23, 2010
    Publication date: February 23, 2012
    Applicant: LifeScan Scotland Ltd.
    Inventors: Gary YOUNG, Michael O'Connell, Ian McArthur, Alan McNeilage, Nick Phippen, Manuel Alvarez-Icaza
  • Publication number: 20120031836
    Abstract: In accordance with particular process, method and system aspects there is provided a biological manner of treating water/wastewater. Treatment is undertaken in bioreactor configured to treat the water/wastewater through a first process of denitrification followed by a second process of biological phosphorus removal. The bioreactor may be defined by multiple stages arranged in compact vertical alignment, for example, to reduce a footprint of the bioreactor and to feed the water/wastewater between the stages using gravity. The stages may comprise, in order, a Deaeration stage, an Anoxic stage, an Anaerobic stage, and an Aerobic stage. Continuous vacuum operation in the Deaeration stage enhances the physical removal of oxygen and other dissolved gases.
    Type: Application
    Filed: August 6, 2010
    Publication date: February 9, 2012
    Inventors: Manuel Alvarez-Cuenca, Maryam Reza
  • Publication number: 20110005941
    Abstract: A method for determining an analyte concentration in blood is described that reduces the effects of hematocrit using a test strip attached to a test meter. The test strip includes a working electrode and a reference electrode. The test meter applies a test voltage between the working electrode and the reference electrode. After a user applies a blood sample containing an analyte onto the test strip, the test meter measures a plurality of test currents for a test time interval.
    Type: Application
    Filed: September 3, 2009
    Publication date: January 13, 2011
    Applicant: LifeScan Scotland Ltd.
    Inventors: Stephen Patrick BLYTHE, Marco F. Cardosi, Leanne Mills, Manuel Alvarez-Icaza, Emma Vanessa Jayne Day, Richard Michael Day, Christopher Philip Leach
  • Patent number: 7834527
    Abstract: Disclosed are electroactive polymer fibers, processes of preparing electroactive polymer fibers, and devices containing electroactive polymer fibers. Devices can be used as actuators and sensors, generators and transducers. Applications include inter alia artificial muscles, prosthetics and robotics.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: November 16, 2010
    Assignee: SmartMotion Technologies, Inc.
    Inventors: Rodrigo Alvarez Icaza Rivera, Juan Manuel Alvarez Sanches, Kevin Chalgren Galloway, Howard Scott Katzenberg, Rahul Kothari, John Vernon Arthur
  • Patent number: 7807031
    Abstract: An improved disposable glucose test strip for use in a test meter of the type which receives a disposable test strip and a sample of blood from a patient and performs an electrochemical analysis is made using a non-conductive integrated reagent/blood separation layer containing a filler, an enzyme effective to oxidize glucose, e.g., glucose oxidase, and a mediator effective to transfer electrons from the enzyme. The integrated layer formulation is printed over a conductive carbon element to form a working electrode. The filler, for example a silica filler, is selected to have a balance of hydrophobicity and hydrophilicity such that one drying it forms a two-dimensional network on the surface of the conductive element. The response of this test strip is essentially temperature independent over relevant temperature ranges and is substantially insensitive to the hematocrit of the patient.
    Type: Grant
    Filed: June 13, 2006
    Date of Patent: October 5, 2010
    Assignee: Diabetes Diagnostics, Inc.
    Inventors: Jerome F. McAleer, Manuel Alvarez-Icaza, Geoff Hall, Elliot V. Plotkin, David Scott, Oliver W. H. Davies
  • Publication number: 20090208734
    Abstract: Various embodiments of a technique in which test strip lots can be prepared without requiring a user to input any calibration information before performing a test measurement with a test strip from the test strip lots. In a first aspect, a method of manufacturing a plurality of test strips by adjusting amount of mediators and working electrode area is described. In another aspect, a method of preparing a reagent ink by adjusting the density of the reagent ink to substantially match a target density is described. In a further aspect, a method using a high numerical Shores Hardness squeegee in conjunction with high pressure is provided. In a further aspect, a method of performing an analyte measurement with a test meter, the test meter being configured to not receive a calibration input, and where the test strip manufactured to any one of the methods or techniques described and illustrated herein.
    Type: Application
    Filed: January 15, 2009
    Publication date: August 20, 2009
    Inventors: Gavin MACFIE, Robert MARSHALL, Manuel ALVAREZ-ICAZA, Kevin DELANEY, Keith DUFFUS, Tim JARVIS, Martin LAMACKA, Nicholas PHIPPEN, Robert RUSSELL
  • Patent number: D636305
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: April 19, 2011
    Assignee: IDDEA, LLC.
    Inventors: Manuel Alvarez, Marcos Alvarez