Patents by Inventor Manuel Buchwald

Manuel Buchwald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cystic fibrosis gene
    Patent number: 6984487
    Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.
    Type: Grant
    Filed: September 20, 1993
    Date of Patent: January 10, 2006
    Assignees: HSC Research Development Corporation, The Board of Regents Acting For and on Behalf of The University of Michigan
    Inventors: Lap-Chee Tsui, John R. Riordan, Francis S. Collins, Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem, Mitchell L. Drumm, Manuel Buchwald
  • Cystic fibrosis gene
    Patent number: 6902907
    Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.
    Type: Grant
    Filed: June 2, 1994
    Date of Patent: June 7, 2005
    Assignees: HSC Research Development Corporation, The Board of Regents Acting for and on Behalf of The University of Michigan
    Inventors: Lap-Chee Tsui, John R. Riordan, Francis S. Collins, Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem, Mitchell L. Drumm, Manuel Buchwald
  • Cystic fibrosis gene
    Patent number: 6730777
    Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 4, 2004
    Assignees: HSC Research Development Corporation, University of Michigan
    Inventors: Lap-Chee Tsui, John R. Riordan, Francis S. Collins, Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem, Mitchell L. Drumm, Manuel Buchwald
  • Cystic fibrosis gene
    Patent number: 6201107
    Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 13, 2001
    Assignees: HSC Research Development Corporation, The Board of Regents, Acting for and on Behalf of the University of Michigan
    Inventors: Tsui Lap-Chee, John R. Riordan, Francis S. Collins, Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem, Mitchell L. Drumm, Manuel Buchwald
  • Stable cell lines expressing the CFTR protein or a mutant of this protein, tool for selecting molecules having an effect on the intracellular transport of these proteins
    Patent number: 5888722
    Abstract: The invention relates to a recombinant nucleic acid, characterized in that it comprises:a nucleotide sequence encoding (coding sequence) the normal CFTR protein,an epitope sequence located at the 3' end of the abovementioned coding sequence,a strong promoter sequence capable of controlling the expression of the abovementioned coding sequence and epitope sequence, when they are integrated into a determined cell.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: March 30, 1999
    Assignees: Institut Curie, Centre National de la Recherche Scientifique
    Inventors: Marie-Alyette Costa De Beauregard, Daniel Louvard, Sylvie Robine, Alexandre Edelman, Dominique Chesnoy-Marchais, Ming Chen, Manuel Buchwald
  • Methods of detecting cystic fibrosis gene by nucleic acid hybridization
    Patent number: 5776677
    Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 7, 1998
    Assignees: HSC Research Development Corporation, The Board of Regents, Acting for and on Behalf of The University of Michigan
    Inventors: Lap-Chee Tsui, John R. Riordan, Francis S. Collins, Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem, Mitchell L. Drumm, Manuel Buchwald
  • Fanconi Anemia Type C gene
    Patent number: 5681942
    Abstract: Fanconi Anemia is a human genetic disease, the precise cause of which is, to date, unknown. This invention provides an isolated human cDNA molecule which is able to specifically complement, in one type of Fanconi Anemia, (type C) the characteristic defect exhibited by cells derived from patients with Fanconi Anemia. The genomic gene from which this cDNA is derived is also provided as is the sequence of the protein encoded by this gene. Mutations in this gene are proposed to underlie Fanconi Anemia Type C. Diagnostic and therapeutic applications which derive from this work are described. The murine homolog of the human cDNA is also provided.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: October 28, 1997
    Assignees: HSC Research & Development Limited Partnership, The United Medical And Dental Schools of Guy's and St. Thomas's Hospitals
    Inventors: Manuel Buchwald, Craig A. Strathdee, Rachel Wevrick, Christopher George Porter Mathew