Patents by Inventor Manuel Dubald

Manuel Dubald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11180770
    Abstract: In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: November 23, 2021
    Assignee: BASF Agricultural Solutions Seed US LLC
    Inventors: Marc Linka, Fabien Poree, Bernd Laber, Gudrun Lange, Christina Thies, Ernst Weber, Michael Strerath, Sandra Geske, Heike Balven-Ross, Nina Wobst, Wayne Coco, Nikolaus Pawlowski, Jan Tebbe, Manuel Dubald
  • Publication number: 20210254091
    Abstract: A method for conferring tolerance to a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor herbicide in a plant by expressing one or more polypeptide components of an exogenous plastoquinone-9 pathway in the plant. Nucleic acids, vectors, transgenic cells and transgenic plants useful in such a method are also disclosed.
    Type: Application
    Filed: June 14, 2019
    Publication date: August 19, 2021
    Applicant: BASF Agricultural Solutions Seed US LLC
    Inventor: Manuel Dubald
  • Publication number: 20210238625
    Abstract: A method for conferring tolerance to a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor herbicide in a plant includes reducing expression of at least one HPPD enzyme in the plant.
    Type: Application
    Filed: October 18, 2018
    Publication date: August 5, 2021
    Inventors: Manuel DUBALD, Marc LINKA
  • Publication number: 20210032651
    Abstract: A method for conferring tolerance to a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor herbicide in a plant, comprising reducing expression of at least one 4-hydroxyphenylpyruvate reductase (HPPR) enzyme in the plant.
    Type: Application
    Filed: October 18, 2018
    Publication date: February 4, 2021
    Inventor: Manuel DUBALD
  • Patent number: 10876130
    Abstract: In the present invention, HPPD enzymes and plants containing them showing a full tolerance against several classes of HPPD-inhibitors are described. A set of HPPD enzymes have been designed which have either no or only a significantly reduced affinity to HPPD inhibitors and, at the same time, the rate of dissociation of the HPPD inhibitors of the enzyme is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding HPPD inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: December 29, 2020
    Assignee: BASF Agricultural Solutions Seed US LLC
    Inventors: Manuel Dubald, Roxanne Armstrong, Fabien Poree, Cheryl Peters
  • Publication number: 20200239905
    Abstract: In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
    Type: Application
    Filed: March 1, 2018
    Publication date: July 30, 2020
    Applicant: BASF Agricultural Solutions Seed US LLC
    Inventors: Marc Linka, Fabien Poree, Bernd Laber, Gudrun Lange, Ernst Weber, Michael Strerath, Sandra Geske, Heike Balven-Ross, Nina Wobst, Wayne Coco, Nikolaus Pawlowski, Jan Tebbe, Christina Thies, Manuel Dubald
  • Patent number: 10597674
    Abstract: In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: March 24, 2020
    Assignee: BASF Agricultural Solutions Seed, US LLC
    Inventors: Marc Linka, Fabien Poree, Bernd Laber, Gudrun Lange, Jan Tebbe, Wayne Coco, Michael Strerath, Ernst Weber, Nikolaus Pawlowski, Sandra Geske, Heike Balven-Ross, Nina Wobst, Christina Thies, Manuel Dubald
  • Publication number: 20200063155
    Abstract: In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
    Type: Application
    Filed: March 1, 2018
    Publication date: February 27, 2020
    Applicant: BASF Agricultural Solutions Seed US LLC
    Inventors: Marc Linka, Fabien Poree, Bernd Laber, Gudrun Lange, Christina Thies, Ernst Weber, Michael Strerath, Sandra Geske, Heike Balven-Ross, Nina Wobst, Wayne Coco, Nikolaus Pawlowski, Jan Tebbe, Manuel Dubald
  • Publication number: 20200002715
    Abstract: In the present invention, HPPD enzymes and plants containing them showing a full tolerance against several classes of HPPD-inhibitors are described. A set of HPPD enzymes have been designed which have either no or only a significantly reduced affinity to HPPD inhibitors and, at the same time, the rate of dissociation of the HPPD inhibitors of the enzyme is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding HPPD inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
    Type: Application
    Filed: August 12, 2019
    Publication date: January 2, 2020
    Inventors: Fabien POREE, Bernd LABER, Gudrun LANGE, Manuel DUBALD, Roxanne ARMSTRONG
  • Patent number: 10400249
    Abstract: In the present invention, HPPD enzymes and plants containing them showing a full tolerance against several classes of HPPD-inhibitors are described. A set of HPPD enzymes have been designed which have either no or only a significantly reduced affinity to HPPD inhibitors and, at the same time, the rate of dissociation of the HPPD inhibitors of the enzyme is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding HPPD inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: September 3, 2019
    Assignee: BASF AGRICULTURAL SOLUTIONS SEED, US LLC
    Inventors: Fabien Poree, Bernd Laber, Gudrun Lange, Manuel Dubald, Roxanne Armstrong
  • Publication number: 20190119697
    Abstract: The present disclosure relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in a plant cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that comprises a DNA binding domain comprising one or more Transcription Activator-Like (TAL) effector monomers specifically ordered to target the genomic locus of interest to improve tolerance of the plant cell to an effective concentration of an inhibitor herbicide.
    Type: Application
    Filed: April 19, 2017
    Publication date: April 25, 2019
    Inventors: Manuel Dubald, Alain Sailland, Yueh-Jiang Hwang, Apurva Bhargava, Adam Bogdanove, Fabio Rinaldi
  • Patent number: 10138490
    Abstract: The present invention relates to transformed plants, in particular transformed plants producing larger amounts of plastoquinones, tocotrienols and tocopherols than non-transformed identical plants. This invention also relates to a method for producing these plants, and to a method for cultivating these plants. The plants according to the invention also have the property of being tolerant to herbicides that are inhibitors of the p-hydroxyphenylpyruvate dioxygenase enzyme.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: November 27, 2018
    Inventors: Michel Matringe, Pascal Rippert, Manuel Dubald, Renaud Dumas
  • Publication number: 20180208937
    Abstract: In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
    Type: Application
    Filed: September 8, 2016
    Publication date: July 26, 2018
    Inventors: Marc Linka, Fabien POREE, Bernd LABER, Gudrun LANGE, Jan TEBBE, Wayne COCO, Michael STRERATH, Ernst WEBER, Nikolaus PAWLOWSKI, Sandra GESKE, Heike BALVEN-ROSS, Nina WOBST, Christina THIES, Manuel DUBALD
  • Publication number: 20170166918
    Abstract: In the present invention, HPPD enzymes and plants containing them showing a full tolerance against several classes of HPPD-inhibitors are described. A set of HPPD enzymes have been designed which have either no or only a significantly reduced affinity to HPPD inhibitors and, at the same time, the rate of dissociation of the HPPD inhibitors of the enzyme is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding HPPD inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
    Type: Application
    Filed: March 10, 2015
    Publication date: June 15, 2017
    Applicants: Bayer CropScience LP, Bayer CropScience AG
    Inventors: Manuel DUBALD, Roxanne ARMSTRONG, Fabien POREE, Cheryl PETERS
  • Publication number: 20170016018
    Abstract: In the present invention, HPPD enzymes and plants containing them showing a full tolerance against several classes of HPPD-inhibitors are described. A set of HPPD enzymes have been designed which have either no or only a significantly reduced affinity to HPPD inhibitors and, at the same time, the rate of dissociation of the HPPD inhibitors of the enzyme is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding HPPD inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
    Type: Application
    Filed: March 9, 2015
    Publication date: January 19, 2017
    Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Fabien POREE, Bernd LABER, Gudrun LANGE, Manuel DUBALD, Roxanne ARMSTRONG
  • Patent number: 8765448
    Abstract: Methods and means are provided for the exact exchange in eukaryotic cells, such as plant cells, of a target DNA sequence for a DNA sequence of interest through homologous recombination, whereby the selectable or screenable marker used during the homologous recombination phase for temporal selection of the gene replacement events can subsequently be removed without leaving a foot-print employing a method for the removal of a selected DNA flanked by two nucleotide sequences in direct repeats.
    Type: Grant
    Filed: June 3, 2008
    Date of Patent: July 1, 2014
    Assignee: Bayer Cropscience, N.V.
    Inventors: Anne Rolland, Manuel Dubald, Michiel Van Lookeren Campagne, Rene Ruiter
  • Publication number: 20120023615
    Abstract: The present invention relates to transplastomic plants free of the selectable marker gene, particularly to leguminous plants, to methods for obtaining such plants and to the vectors and constructs used.
    Type: Application
    Filed: December 31, 2009
    Publication date: January 26, 2012
    Applicant: Bayer CropScience AG
    Inventors: Manuel Dubald, Christelle Lestrade, Bernard Pelissier, Anne Roland
  • Patent number: 7964771
    Abstract: The present invention relates to transplastomic plants free of the selectable marker gene, to a method of obtaining such plants and to the vectors used.
    Type: Grant
    Filed: January 3, 2006
    Date of Patent: June 21, 2011
    Assignee: Bayer Crop Science AG
    Inventors: Ghislaine Tissot, Manuel Dubald, Jean-Marc Ferullo
  • Publication number: 20100175143
    Abstract: Methods and means are provided for the exact exchange in eukaryotic cells, such as plant cells, of a target DNA sequence for a DNA sequence of interest through homologous recombination, whereby the selectable or screenable marker used during the homologous recombination phase for temporal selection of the gene replacement events can subsequently be removed without leaving a foot-print employing a method for the removal of a selected DNA flanked by two nucleotide sequences in direct repeats.
    Type: Application
    Filed: June 3, 2008
    Publication date: July 8, 2010
    Applicants: Bayer BioScience N.V., Bayer CropScience S.A.
    Inventors: Anne Rolland, Manuel Dubald, Michiel Van Lookeren Campagne, Rene Ruiter
  • Publication number: 20090328249
    Abstract: The present invention relates to nucleic acid sequences and methods useful in targeting a recombinant protein encoded by a transgene integrated into the chloroplast genome to the thylakoid lumen of chloroplast, whereby said nucleic acid sequences encode bacterial signal peptides. The invention also relates to means and methods for expressing a disulfide-bond containing protein of interest in a transplastomic plant cell.
    Type: Application
    Filed: July 2, 2007
    Publication date: December 31, 2009
    Inventors: Eric Paget, Manuel Dubald, Julia Bally