Patents by Inventor Manuel Dubald
Manuel Dubald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11371056Abstract: In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.Type: GrantFiled: March 1, 2018Date of Patent: June 28, 2022Assignee: BASF Agricultural Solutions Seed US LLCInventors: Marc Linka, Fabien Poree, Bernd Laber, Gudrun Lange, Ernst Weber, Michael Strerath, Sandra Geske, Heike Balven-Ross, Nina Wobst, Wayne Coco, Nikolaus Pawlowski, Jan Tebbe, Christina Thies, Manuel Dubald
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Patent number: 11279944Abstract: A method for conferring tolerance to a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor herbicide in a plant includes reducing expression of at least one HPPD enzyme in the plant.Type: GrantFiled: October 18, 2018Date of Patent: March 22, 2022Assignee: BASF AGRICULTURAL SOLUTIONS SEED US LLCInventors: Manuel Dubald, Marc Linka
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Patent number: 11180770Abstract: In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.Type: GrantFiled: March 1, 2018Date of Patent: November 23, 2021Assignee: BASF Agricultural Solutions Seed US LLCInventors: Marc Linka, Fabien Poree, Bernd Laber, Gudrun Lange, Christina Thies, Ernst Weber, Michael Strerath, Sandra Geske, Heike Balven-Ross, Nina Wobst, Wayne Coco, Nikolaus Pawlowski, Jan Tebbe, Manuel Dubald
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Publication number: 20210254091Abstract: A method for conferring tolerance to a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor herbicide in a plant by expressing one or more polypeptide components of an exogenous plastoquinone-9 pathway in the plant. Nucleic acids, vectors, transgenic cells and transgenic plants useful in such a method are also disclosed.Type: ApplicationFiled: June 14, 2019Publication date: August 19, 2021Applicant: BASF Agricultural Solutions Seed US LLCInventor: Manuel Dubald
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Publication number: 20210238625Abstract: A method for conferring tolerance to a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor herbicide in a plant includes reducing expression of at least one HPPD enzyme in the plant.Type: ApplicationFiled: October 18, 2018Publication date: August 5, 2021Inventors: Manuel DUBALD, Marc LINKA
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Publication number: 20210032651Abstract: A method for conferring tolerance to a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor herbicide in a plant, comprising reducing expression of at least one 4-hydroxyphenylpyruvate reductase (HPPR) enzyme in the plant.Type: ApplicationFiled: October 18, 2018Publication date: February 4, 2021Inventor: Manuel DUBALD
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Patent number: 10876130Abstract: In the present invention, HPPD enzymes and plants containing them showing a full tolerance against several classes of HPPD-inhibitors are described. A set of HPPD enzymes have been designed which have either no or only a significantly reduced affinity to HPPD inhibitors and, at the same time, the rate of dissociation of the HPPD inhibitors of the enzyme is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding HPPD inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.Type: GrantFiled: March 10, 2015Date of Patent: December 29, 2020Assignee: BASF Agricultural Solutions Seed US LLCInventors: Manuel Dubald, Roxanne Armstrong, Fabien Poree, Cheryl Peters
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Publication number: 20200239905Abstract: In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.Type: ApplicationFiled: March 1, 2018Publication date: July 30, 2020Applicant: BASF Agricultural Solutions Seed US LLCInventors: Marc Linka, Fabien Poree, Bernd Laber, Gudrun Lange, Ernst Weber, Michael Strerath, Sandra Geske, Heike Balven-Ross, Nina Wobst, Wayne Coco, Nikolaus Pawlowski, Jan Tebbe, Christina Thies, Manuel Dubald
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Patent number: 10597674Abstract: In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.Type: GrantFiled: September 8, 2016Date of Patent: March 24, 2020Assignee: BASF Agricultural Solutions Seed, US LLCInventors: Marc Linka, Fabien Poree, Bernd Laber, Gudrun Lange, Jan Tebbe, Wayne Coco, Michael Strerath, Ernst Weber, Nikolaus Pawlowski, Sandra Geske, Heike Balven-Ross, Nina Wobst, Christina Thies, Manuel Dubald
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Publication number: 20200063155Abstract: In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.Type: ApplicationFiled: March 1, 2018Publication date: February 27, 2020Applicant: BASF Agricultural Solutions Seed US LLCInventors: Marc Linka, Fabien Poree, Bernd Laber, Gudrun Lange, Christina Thies, Ernst Weber, Michael Strerath, Sandra Geske, Heike Balven-Ross, Nina Wobst, Wayne Coco, Nikolaus Pawlowski, Jan Tebbe, Manuel Dubald
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Publication number: 20200002715Abstract: In the present invention, HPPD enzymes and plants containing them showing a full tolerance against several classes of HPPD-inhibitors are described. A set of HPPD enzymes have been designed which have either no or only a significantly reduced affinity to HPPD inhibitors and, at the same time, the rate of dissociation of the HPPD inhibitors of the enzyme is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding HPPD inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.Type: ApplicationFiled: August 12, 2019Publication date: January 2, 2020Inventors: Fabien POREE, Bernd LABER, Gudrun LANGE, Manuel DUBALD, Roxanne ARMSTRONG
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Patent number: 10400249Abstract: In the present invention, HPPD enzymes and plants containing them showing a full tolerance against several classes of HPPD-inhibitors are described. A set of HPPD enzymes have been designed which have either no or only a significantly reduced affinity to HPPD inhibitors and, at the same time, the rate of dissociation of the HPPD inhibitors of the enzyme is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding HPPD inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.Type: GrantFiled: March 9, 2015Date of Patent: September 3, 2019Assignee: BASF AGRICULTURAL SOLUTIONS SEED, US LLCInventors: Fabien Poree, Bernd Laber, Gudrun Lange, Manuel Dubald, Roxanne Armstrong
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Publication number: 20190119697Abstract: The present disclosure relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in a plant cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that comprises a DNA binding domain comprising one or more Transcription Activator-Like (TAL) effector monomers specifically ordered to target the genomic locus of interest to improve tolerance of the plant cell to an effective concentration of an inhibitor herbicide.Type: ApplicationFiled: April 19, 2017Publication date: April 25, 2019Inventors: Manuel Dubald, Alain Sailland, Yueh-Jiang Hwang, Apurva Bhargava, Adam Bogdanove, Fabio Rinaldi
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Patent number: 10138490Abstract: The present invention relates to transformed plants, in particular transformed plants producing larger amounts of plastoquinones, tocotrienols and tocopherols than non-transformed identical plants. This invention also relates to a method for producing these plants, and to a method for cultivating these plants. The plants according to the invention also have the property of being tolerant to herbicides that are inhibitors of the p-hydroxyphenylpyruvate dioxygenase enzyme.Type: GrantFiled: March 11, 2005Date of Patent: November 27, 2018Inventors: Michel Matringe, Pascal Rippert, Manuel Dubald, Renaud Dumas
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Publication number: 20180208937Abstract: In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.Type: ApplicationFiled: September 8, 2016Publication date: July 26, 2018Inventors: Marc Linka, Fabien POREE, Bernd LABER, Gudrun LANGE, Jan TEBBE, Wayne COCO, Michael STRERATH, Ernst WEBER, Nikolaus PAWLOWSKI, Sandra GESKE, Heike BALVEN-ROSS, Nina WOBST, Christina THIES, Manuel DUBALD
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Publication number: 20170166918Abstract: In the present invention, HPPD enzymes and plants containing them showing a full tolerance against several classes of HPPD-inhibitors are described. A set of HPPD enzymes have been designed which have either no or only a significantly reduced affinity to HPPD inhibitors and, at the same time, the rate of dissociation of the HPPD inhibitors of the enzyme is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding HPPD inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.Type: ApplicationFiled: March 10, 2015Publication date: June 15, 2017Applicants: Bayer CropScience LP, Bayer CropScience AGInventors: Manuel DUBALD, Roxanne ARMSTRONG, Fabien POREE, Cheryl PETERS
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Publication number: 20170016018Abstract: In the present invention, HPPD enzymes and plants containing them showing a full tolerance against several classes of HPPD-inhibitors are described. A set of HPPD enzymes have been designed which have either no or only a significantly reduced affinity to HPPD inhibitors and, at the same time, the rate of dissociation of the HPPD inhibitors of the enzyme is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding HPPD inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.Type: ApplicationFiled: March 9, 2015Publication date: January 19, 2017Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFTInventors: Fabien POREE, Bernd LABER, Gudrun LANGE, Manuel DUBALD, Roxanne ARMSTRONG
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Patent number: 8765448Abstract: Methods and means are provided for the exact exchange in eukaryotic cells, such as plant cells, of a target DNA sequence for a DNA sequence of interest through homologous recombination, whereby the selectable or screenable marker used during the homologous recombination phase for temporal selection of the gene replacement events can subsequently be removed without leaving a foot-print employing a method for the removal of a selected DNA flanked by two nucleotide sequences in direct repeats.Type: GrantFiled: June 3, 2008Date of Patent: July 1, 2014Assignee: Bayer Cropscience, N.V.Inventors: Anne Rolland, Manuel Dubald, Michiel Van Lookeren Campagne, Rene Ruiter
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Publication number: 20120023615Abstract: The present invention relates to transplastomic plants free of the selectable marker gene, particularly to leguminous plants, to methods for obtaining such plants and to the vectors and constructs used.Type: ApplicationFiled: December 31, 2009Publication date: January 26, 2012Applicant: Bayer CropScience AGInventors: Manuel Dubald, Christelle Lestrade, Bernard Pelissier, Anne Roland
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Patent number: 7964771Abstract: The present invention relates to transplastomic plants free of the selectable marker gene, to a method of obtaining such plants and to the vectors used.Type: GrantFiled: January 3, 2006Date of Patent: June 21, 2011Assignee: Bayer Crop Science AGInventors: Ghislaine Tissot, Manuel Dubald, Jean-Marc Ferullo