Patents by Inventor Manuel Ferrer
Manuel Ferrer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20140193868Abstract: The present invention is in the field of biosynthesis of polyhydroxyalkanoates (PHA). The invention relates to a genetically engineered microorganism having at least one gene involved in the metabolism, preferably in the production, of polyhydroxyalkanoates (PHA). This microorganism is useful in commercial production of polyhydroxyalkanoates. The present invention further relates to a method for the production of polyhydroxyalkanoates (PHA).Type: ApplicationFiled: January 7, 2014Publication date: July 10, 2014Inventors: Julia Sabirova, Peter Golyshin, Manuel Ferrer, Heinrich Lünsdorf, Wolf-Rainer Abraham, Kenneth Timmis
-
Patent number: 8623632Abstract: The present invention is in the field of biosynthesis of polyhydroxyalkanoates (PHA). The invention relates to a genetically engineered microorganism having at least one gene involved in the metabolism, preferably in the production, of polyhydroxyalkanoates (PHA). This microorganism is useful in commercial production of polyhydroxyalkanoates. The present invention further relates to a method for the production of polyhydroxyalkanoates (PHA).Type: GrantFiled: August 9, 2006Date of Patent: January 7, 2014Assignee: Helmholtz-Zentrum fur Infektionsforschung GmbHInventors: Julia Sabirova, Peter Golyshin, Manuel Ferrer, Heinrich Lunsdorf, Wolf-Rainer Abraham, Kenneth Timmis
-
Patent number: 8357407Abstract: This invention describes an agent for cutaneous photoprotection against UVA (I and II) and UVB radiation that contains an aqueous extract obtained from a plant in the Gramineae family from the Antarctic Continent (Deschampsia Antarctica), which presents both antioxidant and dissipation of excess UV radiation properties.Type: GrantFiled: January 30, 2009Date of Patent: January 22, 2013Inventors: Manuel Gidekel, Ramon Lucas Molina Carlevarino, Gustavo Cabrera Barjas, Carlos Sunkel Letelier, Ana Gutierrez Moraga, Juan Pablo Pivel Ranieri, Juan Manuel Ferrer Cuesta, Maria Teresa Sanz Berzosa
-
Publication number: 20120231972Abstract: The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention.Type: ApplicationFiled: March 19, 2010Publication date: September 13, 2012Inventors: Peter N. Golyshin, Olga V. Golyshina, Kenneth N. Timmis, Tatyana Chernikova, Agnes Waliczek, Manuel Ferrer, Ana Beloqul, Maria E. Guazzaroni, Jose M. Vieltes, Florencio Pazos, Antonio Lopez De Lacey, Victor M. Fernandez
-
Patent number: 8003357Abstract: The present invention relates to enzymes having catalytic activity at a pH below 5.0. The present invention provides hydrolyzing enzymes obtainable from archaeobacteria, in detail to hydrolytic enzymes obtainable from the archaeobacterium Ferroplasma acidiphilum. In general, the present invention provides enzymes which are active and stable at acidic pH values, especially at pH values from 1 to 4, especially in the range of pH 2 to 3, obtainable from Ferroplasma acidiphilum, especially to an esterase, glycosidases and a DNA ligase. In addition to stability and activity at low pH values, the enzymes according to the present invention are all dependent on Fe2+ for their catalytic activity.Type: GrantFiled: March 3, 2006Date of Patent: August 23, 2011Assignee: Helmholtz-Zentrum Fuer Infektionsforschung GmbHInventors: Olga Golyshina, Peter Golyshin, Kenneth Timmis, Manuel Ferrer
-
Publication number: 20110195034Abstract: This invention describes a new agent for cutaneous photoprotection against UVA (I and II) and UVB radiation that contains an aqueous extract obtained from a plant in the Gramineae family from the Antarctic Continent (Deschampsia Antarctica), which presents both antioxidant and dissipation of excess UV radiation properties.Type: ApplicationFiled: January 30, 2009Publication date: August 11, 2011Applicants: Vitrogen S.A. 4090 Av. Alvaro Casanova Penalolen, Apoteknos Para la Piel S.IInventors: Manuel Gidekel, Ramon Lucas Molina Carlevarino, Gustavo Cabrera Barjas, Carlos Sunkel Letelier, Ana Gutierrez Moraga, Juan Pablo Pivel Ranieri, Juan Manuel Ferrer Cuesta, Maria Teresa Sanz Berzosa
-
Publication number: 20110183388Abstract: The present invention is in the field of biosynthesis of polyhydroxyalkanoates (PHA). The invention relates to a genetically engineered microorganism having at least one gene involved in the metabolism, preferably in the production, of polyhydroxyalkanoates (PHA). This microorganism is useful in commercial production of polyhydroxyalkanoates. The present invention further relates to a method for the production of polyhydroxyalkanoates (PHA).Type: ApplicationFiled: August 9, 2006Publication date: July 28, 2011Inventors: Julia Sabirova, Peter Golyshin, Manuel Ferrer, Heinrich Lunsdorf, Wolf-Rainer Abraham, Kenneth Timmis
-
Patent number: 7811784Abstract: The invention relates to the growth temperature of organisms, especially plants and microorganisms and the manipulation of the tolerable cultivation temperature. More specifically, the present invention relates to the expression of heterologous proteins in microorganisms, and especially to the heterologous expression of heat sensitive proteins in bacteria, either gram-negative or gram-positive. In a first aspect, the present invention provides a method for manipulation of cells and the resultant cells, wherein at least one gene from a psychrophilic micro organism coding for at least one chaperone or chaperonin is expressed. Such cells are selected among cultivated eukaryotic cells, i.e. animal and plant cells and entire plants, gram-negative and gram-positive bacteria, fungi and yeasts.Type: GrantFiled: October 11, 2004Date of Patent: October 12, 2010Assignee: Helmholtz-Zentrum für Infektionsforschung GmbHInventors: Manuel Ferrer, Kenneth Timmis, Tatjana Chernikova, Peter Golyshin, Michail Yakimov
-
Publication number: 20100196965Abstract: The present invention relates to enzymes having catalytic activity at a pH below 5.0. The present invention provides hydrolyzing enzymes obtainable from archaeobacteria, in detail to hydrolytic enzymes obtainable from the archaeobacterium Ferroplasma acidiphilum. In general, the present invention provides enzymes which are active and stable at acidic pH values, especially at pH values from 1 to 4, especially in the range of pH 2 to 3, obtainable from Ferroplasma acidiphilum, especially to an esterase, glycosidases and a DNA ligase. In addition to stability and activity at low pH values, the enzymes according to the present invention are all dependent on Fe2+ for their catalytic activity.Type: ApplicationFiled: March 3, 2006Publication date: August 5, 2010Inventors: Olga Golyshina, Peter Golyshin, Kenneth Timmis, Manuel Ferrer
-
Publication number: 20090305339Abstract: The invention relates to a new laccase from rumen, namely the RL5 laccase. In particular, the invention relates to a polypeptide comprising the amino acid sequence shown in FIG. 11 and comprising at least the amino acids No. 80 to No. 150 of the amino acid sequence shown in FIG. 11, respectively. The invention also relates to the use of polypeptides further comprising the amino acid sequence of a DUF152 domain with a core sequence as shown in FIG. 18 as laccases. Furthermore, the invention relates to methods for producing inventive polypeptides and their use.Type: ApplicationFiled: February 23, 2007Publication date: December 10, 2009Applicants: VIALACTIA BIOSCIENCES (NZ) LIMITED, HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBHInventors: Carsten Strompl, Manuel Ferrer, Tatyana Chernikova, Olga Golyshina, Kenneth Timmis, Kieran Elborough, Graeme Jarvis, Peter Golyshin
-
Publication number: 20090255014Abstract: The invention relates to the growth temperature of organisms, especially plants and microorganisms and the manipulation of the tolerable cultivation temperature. More specifically, the present invention relates to the expression of heterologous proteins in microorganisms, and especially to the heterologous expression of heat sensitive proteins in bacteria, either gram-negative or gram-positive. In a first aspect, the present invention provides a method for manipulation of cells and the resultant cells, wherein at least one gene from a psychrophilic micro organism coding for at least one chaperone or chaperonin is expressed. Such cells are selected among cultivated eukaryotic cells, i.e. animal and plant cells and entire plants, gram-negative and gram-positive bacteria, fungi and yeasts.Type: ApplicationFiled: October 11, 2004Publication date: October 8, 2009Inventors: Manuel Ferrer, Kenneth Timmis, Tatjana Chernikova, Peter Golyshin, Michail Yakimov
-
Publication number: 20090149531Abstract: The present invention is a chemical composition including: Use of the compound with the chemical formula can be applied in pharmaceutical compositions for the treatment of psoriasis.Type: ApplicationFiled: December 10, 2008Publication date: June 11, 2009Applicant: APOTEKNOS PARA LA PIEL, S.L.Inventors: Juan Pablo PIVEL RANIERI, Juan Manuel Ferrer Cuesta, Fernando Martinez Galan, Juan Manuel Irache, Jose Luis Novella Robisco, Juan Jose Perez Rueda, Ma Paz Maria Martin, Julio Alvarez-Builla Gomez, Jaime Bermejo, Fernando Vidal Vanaclocha
-
Publication number: 20090078384Abstract: The invention provides polypeptides coding for new esterases from rumen. The invention also relates to functional fragments or functional derivatives thereof as well as to nucleic acids encoding the polypeptides of the invention, vectors and host cells containing said nucleic acids, a method for producing the polypeptides and the use of the polypeptides according to the present invention for various industrial purposes and medical treatments. The invention also relate to the conversion of said esterases into lipases.Type: ApplicationFiled: July 6, 2005Publication date: March 26, 2009Inventors: Manuel Ferrer, Peter Golyshin, Olga Golyshina, Tatyana Chernikova, Carsten Strompl, Kenneth Timmis, Kieran Elborough, Graeme Jarvis
-
Publication number: 20080261267Abstract: The invention provides polypeptides coding for new cellulases from rumen, particularly from rumen ecosystem. The invention also relates to functional fragments or functional derivatives thereof as well as to nucleic acids encoding the polypeptides of the invention, vectors and host cells containing said nucleic acids, a method for producing the polypeptides and the use of the polypeptides according to the present invention for various industrial purposes and medical treatments.Type: ApplicationFiled: June 30, 2005Publication date: October 23, 2008Inventors: Manuel Ferrer, Peter Golyshin, Olga Golyshina, Tatyana Chernikova, Carsten Strompl, Kenneth Timmis, Kieran Elborough, Graeme Jarvis