Patents by Inventor Manuel Garber

Manuel Garber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR DIFFERENTIAL CAS9 GENE LABELING AND/OR EDITING
    Publication number: 20210340566
    Abstract: The present disclosure relates to methods of and systems for modifying the transcriptional regulation of stem or progenitor cells to promote their differentiation or reprogramming of somatic cells. Further, the labeling and editing of human genomic loci in live cells with three orthogonal CRISPR/Cas9 components allow multicolor detection of genomic loci with high spatial resolution, which provides an avenue for barcoding elements of the human genome in the living state.
    Type: Application
    Filed: March 12, 2021
    Publication date: November 4, 2021
    Inventors: THORU PEDERSON, SCOT ANDREW WOLFE, HANHUI MA, Metewo Selase Kosi Enuameh, Nicola Anne Kearns, Ryan Michael Jude Genga, Rene Maehr, Shaojie Zhang, Ardalan Naseri, Manuel Garber
  • METHODS OF TREATING INFLAMMATION
    Publication number: 20180289709
    Abstract: The present invention relates to methods of decreasing inflammation by inhibiting polo-like kinase (Plk)
    Type: Application
    Filed: October 12, 2017
    Publication date: October 11, 2018
    Inventors: Aviv Regev, Ido Amit, Nir Hacohen, Manuel Garber, Nicolas Chevrier
  • CAS9 EFFECTOR-MEDIATED REGULATION OF TRANSCRIPTION, DIFFERENTIATION AND GENE EDITING/LABELING
    Publication number: 20150191744
    Abstract: The present disclosure relates to methods of and systems for modifying the transcriptional regulation of stem or progenitor cells to promote their differentiation or reprogramming of somatic cells. Further, the labeling and editing of human genomic loci in live cells with three orthogonal CRISPR/Cas9 components allow multicolor detection of genomic loci with high spatial resolution, which provides an avenue for barcoding elements of the human genome in the living state.
    Type: Application
    Filed: December 16, 2014
    Publication date: July 9, 2015
    Inventors: Scot Andrew Wolfe, Hanhui Ma, Thoru Pederson, Metewo Selase Kosi Enuameh, Nicola Anne Kearns, Ryan Michael Jude Genga, Rene Maehr, Shaojie Zhang, Ardalan Naseri, Manuel Garber
  • Methods of Treating Inflammation
    Publication number: 20140011812
    Abstract: The present invention relates to methods of decreasing inflammation by inhibiting polo-like kinase (PlK)
    Type: Application
    Filed: October 7, 2011
    Publication date: January 9, 2014
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College, The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: Aviv Regev, Ido Amit, Nir Hacohen, Manuel Garber, Nicolas Chevrier