Patents by Inventor Manuel Gidekel

Manuel Gidekel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230293563
    Abstract: Methods and compositions are provided to treat colorectal tumors. Tricin 7-O-?-D-glucopyranoside (Antartina) in combination with AdIL-12 is shown to be effective in preventing or inhibiting growth of colorectal tumors as well as in eradication of the tumors. Method, and treatment for treating colorectal tumors are suggested.
    Type: Application
    Filed: November 2, 2022
    Publication date: September 21, 2023
    Inventor: Manuel Gidekel
  • Patent number: 11534449
    Abstract: Provided are compositions and methods for treatment of cancer and for adoptive T cell therapy (ACT). The compositions comprise one or more derivatives of tricin 7-O-?-D-glucopyranoside (ANTARTINA®). The compositions comprise one or more pharmaceutically acceptable excipients convenient for delivery of the tricin 7-O-?-D-glucopyranoside derivatives. Tricin 7-O-?-D-glucopyranoside derivatives described herein include acetylated tricin 7-O-?-D-glucopyranoside, as well as glucose, maltose, cellobiose, lactose, xylose, and galactose derivatives. The methods include treatment, or reduction in the risk of suffering from, colorectal cancer and hepatocellular cancer.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: December 27, 2022
    Assignee: NEOCAGE SL
    Inventors: Manuel Gidekel, Jose Luis Novella Robisco, Mario Nicolas Banduc
  • Publication number: 20200261486
    Abstract: Provided are compositions and methods for treatment of cancer and for adoptive T cell therapy (ACT). The compositions comprise one or more derivatives of tricin 7-O-?-D-glucopyranoside (ANTARTINA®). The compositions comprise one or more pharmaceutically acceptable excipients convenient for delivery of the tricin 7-O-?-D-glucopyranoside derivatives. Tricin 7-O-?-D-glucopyranoside derivatives described herein include acetylated tricin 7-O-?-D-glucopyranoside, as well as glucose, maltose, cellobiose, lactose, xylose, and galactose derivatives. The methods include treatment, or reduction in the risk of suffering from, colorectal cancer and hepatocellular cancer.
    Type: Application
    Filed: February 14, 2019
    Publication date: August 20, 2020
    Inventors: MANUEL GIDEKEL, JOSE LUIS NOVELLA ROBISCO, MARIO NICOLAS BANDUC
  • Patent number: 10194666
    Abstract: The present invention provides for a process for repairing damage to wood and related cellulosic products caused by termites and other wood damaging insects comprising the steps of providing a modification of the bacteria of the genus gluconacetobacter toxic to termites and other wood damaging insects; converting said bacterial modification into a bait attractive to termites and other wood damaging insects as a source of food; and allowing said bacterial modification to produce a by-product ooze capable of repairing would damaged by termites and other wood damaging insects. The process causes the build-up of wood like material, thus effectively repairing the termite damaged areas.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: February 5, 2019
    Assignee: ICyT SpA
    Inventor: Manuel Gidekel
  • Patent number: 10190181
    Abstract: The present invention provides for a bio-nematocide for repairing damage to wood and related cellulosic products caused by nematodes.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: January 29, 2019
    Assignee: ICyT SpA
    Inventor: Manuel Gidekel
  • Patent number: 10058582
    Abstract: The chemically synthesized compound Tricin 7-O-beta-D-glucopyranoside, native to the plant Deschampsia Antarctica and present in aqueous extracts of the plant Deschampsia Antarctica said compound having the ability to inhibit tumor growth in mammals with colorectal carcinoma.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: August 28, 2018
    Assignee: Antartina LLC
    Inventors: Manuel Gidekel, Julio Alvarez Builla, Guillermo Mazzolini
  • Publication number: 20170335414
    Abstract: The present invention provides for a bio-nematocide for repairing damage to wood and related cellulosic products caused by nematodes.
    Type: Application
    Filed: October 7, 2016
    Publication date: November 23, 2017
    Applicant: INVERSIONES, CIENCIA Y TECNOLOGIA SPA
    Inventor: Manuel Gidekel
  • Publication number: 20170332644
    Abstract: The present invention provides for a process for repairing damage to wood and related cellulosic products caused by termites and other wood damaging insects comprising the steps of providing a modification of the bacteria of the genus gluconacetobacter toxic to termites and other wood damaging insects; converting said bacterial modification into a bait attractive to termites and other wood damaging insects as a source of food; and allowing said bacterial modification to produce a by-product ooze capable of repairing would damaged by termites and other wood damaging insects.
    Type: Application
    Filed: October 7, 2016
    Publication date: November 23, 2017
    Applicant: INVERSIONES, CIENCIA Y TECNOLOGIA SPA
    Inventor: Manuel Gidekel
  • Publication number: 20170049839
    Abstract: The chemically synthesized compound Tricin 7-O-beta-D-glucopyranoside, native to the plant Deschampsia Antarctica and present in aqueous extracts of the plant Deschampsia Antarctica said compound having the ability to inhibit tumor growth in mammals with colorectal carcinoma.
    Type: Application
    Filed: August 12, 2016
    Publication date: February 23, 2017
    Inventors: MANUEL GIDEKEL, Julio Alvarez Builla, Guillermo Mazzolini
  • Patent number: 9491950
    Abstract: The present invention provides for the first time a biological system which provides the dual function of killing termites and other wood damaging insects while also producing a by-product substance having the capability of repairing damage by termites and other insects to wood and related cellulosic products. The present invention, a biological system, toxic to termites, is provided which produces a means by which damage caused by termites is repaired, said means comprising a by-product produced by a modification of the bacteria of the genus Gluconacetobacter. Preferably, the biological system is in the form of toxic bait.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: November 15, 2016
    Assignee: ICY T
    Inventor: Manuel Gidekel
  • Patent number: 9426950
    Abstract: This invention discloses a process for the propagation and survival of Deschampsia antarctica suitable for industrial scale production. In particular, the process defines selected bioreactor conditions whereby morphologically high quality plants are obtained at high rates. This invention further discloses a bioreactor design which includes a design for automated temporary immersion of explants in a culture medium.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: August 30, 2016
    Assignee: Uxmal S.A.
    Inventor: Manuel Gidekel
  • Publication number: 20160174568
    Abstract: The present invention provides for the first time a biological system which provides the dual function of killing termites and other wood damaging insects while also producing a by-product substance having the capability of repairing damage by termites and other insects to wood and related cellulosic products. The present invention, a biological system, toxic to termites, is provided which produces a means by which damage caused by termites is repaired, said means comprising a by-product produced by a modification of the bacteria of the genus Gluconacetobacter. Preferably, the biological system is in the form of toxic bait.
    Type: Application
    Filed: June 26, 2014
    Publication date: June 23, 2016
    Inventor: Manuel Gidekel
  • Patent number: 9056133
    Abstract: This invention is related to the field of cancer treatment, more specifically to gene therapy in combination with a suitable chemotherapeutic agent. The present invention is related to a new oncolytic virus, which is able to inhibit the growth of malignant tumors or is a treatment of hyperproliferative mammalian cells, or is a treatment of cancer. The oncolytic virus works in combination with a suitable chemotherapeutic agent. More specifically, the present invention provides a pharmaceutical kit comprising an oncolytic adenovirus and a chemotherapeutic agent, and a method for the treatment of cancer.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: June 16, 2015
    Assignee: CTI-S.A.
    Inventors: Osvaldo Podhajcer, Manuel Gidekel, Eduardo Cafferata, Helga Weber
  • Publication number: 20140328944
    Abstract: This invention encompasses a novel composition comprising silenced CTBP-1 combined with a compound selected from among 5-FU, Cisplatin and Epirubicin. The invention further relates to a method of treating gastric cancer with a combination of siRNA silenced CTBP-1 and a compound selected from among 5-FU, Cisplatin and Epirubicin.
    Type: Application
    Filed: May 2, 2013
    Publication date: November 6, 2014
    Inventors: Manuel Gidekel, Carolina Bizama, Osvaldo Podhajcer
  • Publication number: 20140287074
    Abstract: The present invention relates to natural extracts as a source of therapeutic compounds for human use, specifically for curing and preventing cancerous and tumorous conditions. More specifically, the present invention relates to extracts, compositions or the extracts and methods to produce the extracts from Deschampsia antarctica for prevention of cancer.
    Type: Application
    Filed: March 21, 2013
    Publication date: September 25, 2014
    Applicant: Uxmal S.A., Chile
    Inventors: Manuel Gidekel, Helga Weber Rascheya, Eduardo Gustavo Cafferata, Ana Gutierrez, Carlos Sunkel, Jennifer Osorio Navarro
  • Publication number: 20140235466
    Abstract: This invention pertains generally to the fields of molecular biology and medical diagnosis. More particularly this invention provides novel biomarkers for the detection of pancreatic cancer comprising at least one messenger RNA and/or up-regulated peptide in pancreatic cancer. The present invention provides biomarkers capable of discriminating between non-neoplastic pancreatic tissues and ductal adenocarcinoma tissues and can be correlated with a probable diagnosis of pancreatic cancer as well as assessing the efficacy of ongoing therapies for this disease.
    Type: Application
    Filed: February 21, 2013
    Publication date: August 21, 2014
    Inventor: Manuel Gidekel
  • Publication number: 20140144080
    Abstract: This invention discloses a process for the propagation and survival of Deschampsia antarctica suitable for industrial scale production. In particular, the process defines selected bioreactor conditions whereby morphologically high quality plants are obtained at high rates. This invention further discloses a bioreactor design which includes a design for automated temporary immersion of explants in a culture medium.
    Type: Application
    Filed: November 27, 2012
    Publication date: May 29, 2014
    Inventor: Manuel Gidekel
  • Publication number: 20130130354
    Abstract: This invention provides information on differentially expressed genes in malignant tissue of gastric, colon and pancreatic adenocarcinomas as compared to their corresponding adjacent non-malignant tissues. These genes or their products can be used as targets in developing new strategies for the treatment and diagnosis of these gastrointestinal cancers.
    Type: Application
    Filed: August 10, 2011
    Publication date: May 23, 2013
    Applicant: CTI Salud S.A.
    Inventors: Manuel Gidekel, Carolina Del Carmen Bizama Soto, Felipe Mario Benavente Muñoz, Hieda Ana Gutievez Moraga, Osvaldo Luis Podhajcer, Edgardo Enrique Salvatierra Colussi, Guiller Mo Daniel Mazzolini, Juan Carlos Roa
  • Patent number: 8415271
    Abstract: Strains of psychrophilic bacteria isolated from the rizosphere of Deschampsia antarctica are characterized and biofertilizer compositions comprising one or more of these psychrophilic bacteria strains are disclosed.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: April 9, 2013
    Assignee: Uxmal S.A.
    Inventors: Manuel Gidekel, Ana Gutierrez, Leticia Barrientos, Gustavo Cabrera, Graciela Berrios, Ivan Mihovilovic
  • Publication number: 20130084263
    Abstract: This invention is related to the field of cancer treatment, more specifically to gene therapy in combination with a suitable chemotherapeutic agent. The present invention is related to a new oncolytic virus, which is able to inhibit the growth of malignant tumors or is a treatment of hyperproliferative mammalian cells, or is a treatment of cancer. The oncolytic virus works in combination with a suitable chemotherapeutic agent. More specifically, the present invention provides a pharmaceutical kit comprising an oncolytic adenovirus and a chemotherapeutic agent, and a method for the treatment of cancer.
    Type: Application
    Filed: May 21, 2012
    Publication date: April 4, 2013
    Inventors: Osvaldo Podhajcer, Manuel Gidekel, Eduardo Cafferata