Abstract: The present disclosure includes a method for treating or ameliorating a cancer or the effects of a cancer in a subject in need thereof comprising administering to the subject an effective amount of a hedgehog inhibitor (HHI) or a pharmaceutically acceptable salt thereof, and a chemotherapeutic agent (CTA).

Abstract: A composition including: a PF polymer including units derived from vinylidene fluoride; and a PA polymer including units derived from a (meth)acrylic monomer and units including at least one associative group chosen among imidazolidonyl, triazolyl, triazinyl, bis-ureyl and ureido-pyrimidyl groups; in solution in a solvent. Also, the use of this composition for the production of electronic devices.

Abstract: A process for manufacturing a solution of a fluorocopolymer in a solvent, the solvent having a boiling point above or equal to 150° C. at 1013 hPa and/or a saturation vapour pressure less than or equal to 5 hPa at 20° C., the process including a step of mixing said fluoropolymer with the solvent in a reactor having a stirring spindle including at least one blade, at a mixing temperature ranging from 40° C. to 100° C., and at a blade tip stirring speed of greater than or equal to 0.1 m/s, until said polymer has dissolved in the solvent. Also, a solution of the copolymer in this solvent that includes no co-solvent having a boiling point strictly below 150° C. at 1013 hPa and/or a saturation vapour pressure strictly greater than 5 hPa at 20° C.

Abstract: Methods of culturing T cells with a 4-1BBL fusion polypeptide are provided. Accordingly there is provided a method of culturing T cells comprising adding to immune cells comprising T cells obtained from a subject having a pathology a PD1-4-1BBL or a SIRPalpha-4-1BBL fusion polypeptide; and culturing the immune cells with the fusion polypeptide for more than 7 days. Also provided are T cells obtainable by the method and uses thereof.

Abstract: Methods of culturing T cells are provided. Accordingly there is provided a method of culturing T cells comprising adding to immune cells comprising T cells obtained from a subject having a pathology a non-cellular agent capable of binding 4-1BB and activating said 4-1BB signaling pathway; and culturing the immune cells with said agent for more than 7 days. Also provided are T cells obtainable by the method and uses thereof.

Abstract: Methods and products for the identification and detection of new pancreatic cancer biomarkers based on proteins in biofluids, such as plasma and serum extracellular vesicles.

Abstract: Provided herein are methods for obtaining tumor-targeting T cells, as well as for identifying tumor-targeting TCRs.

Abstract: The present disclosure includes a method for treating or ameliorating a cancer or the effects of a cancer in a subject in need thereof comprising administering to the subject an effective amount of a hedgehog inhibitor (HHI) or a pharmaceutically acceptable salt thereof, and a chemotherapeutic agent (CTA).

Abstract: A cell culture platform that uses a combination of sophisticated tissue engineering technologies to co-culture patient-derived tumor cells and the patient's own immune cells and create the conditions for expansion of tumor targeting T cells in culture. The platform can be used, e.g., for personalized medicine.

Abstract: The present invention relates to a solid polymer electrolyte in the form of an organic-organic composite material, intended to be used in a lithium-polymer battery. The invention also relates to a process for manufacturing such an electrolyte. This electrolyte is notably intended for making a lithium-polymer battery or an “all-solid” battery, notably as regards the ion-conducting separator. The invention thus also relates to a battery separator comprising such a polymer electrolyte, to processes for manufacturing same and to the battery incorporating this electrolyte.

Abstract: A process for preparing a porous film of a fluoropolymer, including the following steps: the provision of an ink including the fluoropolymer and a vehicle including a solvent for the fluoropolymer and a nonsolvent for the fluoropolymer, the solvent for the fluoropolymer and the nonsolvent for the fluoropolymer being mutually miscible; the deposition of the ink on a substrate; the evaporation of the vehicle comprising the solvent and the nonsolvent.

Abstract: A composition including: a PF polymer including units derived from vinylidene fluoride; and a PA polymer including units derived from a (meth)acrylic monomer and units including at least one associative group chosen among imidazolidonyl, triazolyl, triazinyl, bis-ureyl and ureido-pyrimidyl groups; in solution in a solvent. Also, the use of this composition for the production of electronic devices.

Abstract: The invention relates to crosslinkable compositions based on electroactive fluorinated copolymers, to crosslinked films obtained from such compositions and also to a process for preparing these films. The invention also relates to the use of said films as a dielectric layer in various (opto)electronic devices: piezoelectric, ferroelectric or pyroelectric devices.

Abstract: The invention relates to a compound of formula (I), wherein: A1 and A2 represent, independently of one another, a binding group comprising at least one nitrogen atom; Q1 and Q2 represent, independently of one another, a linkage group; and x is an integer between 2 and 6, preferably between 3 and 6. The invention also relates to a rubber composition comprising said compound.

Abstract: The invention relates to a compound of formula (I), wherein: A represents a binding group comprising at least one nitrogen atom; Q1 and Q2 represent, independently of one another, a linkage group; x is an integer between 2 and 6; and Z represents the group of formula (I), wherein each R? represents, independently, an alkyl group having between 1 and 4 carbon atoms. The invention also relates to a rubber composition comprising said compound.

Abstract: The invention is directed to a photovoltaic module containing at least one first transparent layer forming the front face of the module, a plurality of photovoltaic cells, an encapsulating assembly encapsulating the plurality of photovoltaic cells, a second layer forming the rear face of the module, characterized in that at least one of the first and second layers is composed of a polymer material, in which recesses are formed that constitute expansion joints, produced as a one-piece component, and in that the recesses are at least partially occupied by a “soft” joining material having a Young's modulus less than that of the polymer material of the at least one of the first and second layers and a thickness less than or equal to that of the at least one of the first and second layers. The recesses are at least partially through-recesses.

Abstract: A photovoltaic module including a transparent first layer forming a front face, plural photovoltaic cells, and an assembly encapsulating the photovoltaic cells. The first layer includes plural plates independent from each other, each plate located opposite a photovoltaic cell. Rigidity of the encapsulating assembly is defined by a Young's modulus of encapsulation material greater than or equal to 75 MPa at ambient temperature and a thickness of the encapsulating assembly between 0.4 and 1 mm. The first layer includes at least one transparent polymer material of acrylic block copolymers or a composition including at least one acrylic block copolymer having formula (A)nB, in which: n is an integer greater than or equal to 1; A is an acrylic or methacrylic homo- or copolymer having a glass transition temperature greater than 50° C.; and B is an acrylic or methacrylic homo- or copolymer having a glass transition temperature less than 20° C.

Abstract: A compound consisting of a linear saturated C8-C24 hydrocarbon-based chain bearing at each end a nitrogen-containing functional group, other than —NH2, is used for the storage of thermal energy. A process for the storage and optionally for the release of thermal energy comprises the contacting of a wall to be cooled with a first heat transfer fluid then of said first heat transfer fluid with a material comprising said compound and optionally the contacting of said material with a second heat transfer fluid then of said second heat transfer fluid with a wall to be heated.

Abstract: The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient.

Abstract: The present invention relates to a material comprising dendritic molecules each constituted of fragments that are at least bifunctional and of fragments that are at least trifunctional joined together by ester or thioester bridges, alone or in combination with amide or urea bridges, said bridges being formed from two functions carried by different fragments, said molecules containing, on the fragments located at the ends of the dendritic branches, associative end groups capable of forming associations with one another by hydrogen bonds and joined covalently to the functions that are not involved in said bridges. It also relates to the method of production thereof, as well as to its uses and to compositions, notably cosmetic, containing this material.