Patents by Inventor Manuel Hidalgo MEDINA

Manuel Hidalgo MEDINA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and uses for treating cancer
    Patent number: 11911374
    Abstract: The present disclosure includes a method for treating or ameliorating a cancer or the effects of a cancer in a subject in need thereof comprising administering to the subject an effective amount of a hedgehog inhibitor (HHI) or a pharmaceutically acceptable salt thereof, and a chemotherapeutic agent (CTA).
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: February 27, 2024
    Assignee: NELUM CORPORATION
    Inventor: Manuel Hidalgo Medina
  • METHODS OF CULTURING T CELLS WITH A 4-1BBL FUSION POLYPEPTIDE AND USES OF SAME
    Publication number: 20230048719
    Abstract: Methods of culturing T cells with a 4-1BBL fusion polypeptide are provided. Accordingly there is provided a method of culturing T cells comprising adding to immune cells comprising T cells obtained from a subject having a pathology a PD1-4-1BBL or a SIRPalpha-4-1BBL fusion polypeptide; and culturing the immune cells with the fusion polypeptide for more than 7 days. Also provided are T cells obtainable by the method and uses thereof.
    Type: Application
    Filed: December 30, 2020
    Publication date: February 16, 2023
    Applicants: KAHR Medical Ltd., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Senthil Kumar MUTHUSWAMY, Manuel HIDALGO MEDINA, Qingda MENG, Yaron PEREG, Ayelet CHAJUT
  • METHODS OF CULTURING T CELLS AND USES OF SAME
    Publication number: 20230048361
    Abstract: Methods of culturing T cells are provided. Accordingly there is provided a method of culturing T cells comprising adding to immune cells comprising T cells obtained from a subject having a pathology a non-cellular agent capable of binding 4-1BB and activating said 4-1BB signaling pathway; and culturing the immune cells with said agent for more than 7 days. Also provided are T cells obtainable by the method and uses thereof.
    Type: Application
    Filed: December 30, 2020
    Publication date: February 16, 2023
    Applicants: KAHR Medical Ltd., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Senthil Kumar MUTHUSWAMY, Manuel HIDALGO MEDINA, Qingda MENG, Yaron PEREG, Ayelet CHAJUT
  • METHODS AND USES FOR TREATING CANCER
    Publication number: 20220071982
    Abstract: The present disclosure includes a method for treating or ameliorating a cancer or the effects of a cancer in a subject in need thereof comprising administering to the subject an effective amount of a hedgehog inhibitor (HHI) or a pharmaceutically acceptable salt thereof, and a chemotherapeutic agent (CTA).
    Type: Application
    Filed: January 20, 2021
    Publication date: March 10, 2022
    Inventor: Manuel Hidalgo MEDINA