Abstract: The present invention relates to the transformation of food-grade sugars containing D-fructose, in caramels enriched in oligosaccharides with prebiotic activity by using solid acid catalysts, such as zeolites, clays or ion-exchange resins in its acid form, under heterogeneous conditions, or by using soluble acid polymer catalysts of high molecular weight, under homogeneous conditions, with the possibility of recycling the catalyst, being compatible with discontinuous or continuous production processes. The resulting caramel exhibits prebiotic properties, favoring the development of a beneficial intestinal flora and a repairing effect in the damaged colon.