Abstract: Antibody-drug conjugates (ADCs) comprising an antibody construct that binds specifically binds human folate receptor alpha (FR?) (an anti-FR? antibody construct) conjugated to a camptothecin analogue of Formula (I). The ADCs are useful as therapeutics, in particular in the treatment of cancer.

Abstract: Camptothecin analogues of Formula (I) and conjugates comprising the camptothecin analogues are described. The camptothecin analogues and conjugates may be used as therapeutic agents, particularly in the treatment of cancer, an autoimmune disease or a viral infection.

Abstract: A thermally coated component is disclosed. The thermally coated component has a frictionally optimized surface of a track for a friction partner, where the surface has pores. The pores have an entry rounding, the slope of which, as a ratio of the depth of the entry rounding to a longitudinal section of the surface or parallel to the surface, has a value of more than 2.5 ?m/mm.

Abstract: A method for coating a substrate in which a wire-like spray material based on iron is melted in an electric arc and is isolated as a layer on the substrate is disclosed. The following alloy components are contained in the spray material: carbon: 0.1% by weight to 0.3% by weight; manganese: 1.5% by weight to 2.0% by weight; and silicon: 0.25% by weight to 0.4% by weight, respectively with regard to a total weight. The substrate is an aluminium alloy and the surface thereof is roughened mechanically before the coating in such a way that a roughness is formed with undercuts which are filled with the spray material over the course of the coating and therefore a cause a mechanical interlocking of the coating with the substrate. The coating is removed on the surface. An electric arc wire sprayed layer based on iron on the substrate is also disclosed.

Abstract: A thermally coated component that has a frictionally optimized surface of a raceway for a frictional counterpart. The frictionally optimized surface has a theoretical oil retention volume VOil of 10 to 800 ?m3/mm2, which can be pre-determined by a component coating surface simulation. A method for the component coating surface simulation of a thermally coated component is furthermore disclosed, with parameter determination for surface structures of the component coating surface, wherein a parameter simulates a function between the component coating surface and the frictional counterpart.