Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, ?v?1 integrin and ?v?6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: The present invention refers to a composition comprising cannabinoid loaded polymer submicroparticles soluble in aqueous media comprising a polyelectrolyte complex formed by a positive charged polymer, selected from chitosan or a derivative thereof, a negative charged polymer selected from hyaluronic acid or a derivative thereof, and a cannabinoid, or a derivative thereof, or a mixture of cannabinoids, or derivatives thereof, and water, wherein the size of the submicroparticles is 600-750 nm, the weight ratio of positive charged polymer/negative charged polymer is 2.6:1-3.8:1, and the weight ratio polymers/cannabinoid is 100:1 to 1:100, wherein the cannabinoids are arranged in hydrophobic patches formed between the positive charged polymer and the negative charged polymer chains. The method of producing said composition and its nutraceutical, pharmaceutical and cosmetic uses are also contemplated.

Abstract: An energy and hydrogen transport system includes a duct to transfer hydrogen. The duct has a pump or fan driven by an electric motor to pressurize or create a vacuum therein. A double walled container stores hydrogen.

Abstract: Oxidizer and fuel supply system for internal combustion engines, which includes oxygen supplies for the engines, particle filters, oxygen generators using nanofilters, pressurized oxygen bottles and air compressors, O2 loading media, by means of bottles, carboys or interchangeable tanks or hoses, Complementary means of nanomolecular membrane filters that separate O2 from air, performing the separation by means of aspiration or suction from the combustion engine or the suction or impulsion of a pump or compressor driven by an electric motor or mechanically by the combustion engine itself; Storage means for the separated or obtained O2; means for controlling the variable fuel/O2 mixture by means of a processor or an ECU (engine control unit); and as fuel: synthetic fuel, hydrocarbons, alcohols or hydrogen.

Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: The invention relates to methods of therapy using compounds of formula (I) and formula (II): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (II) and pharmaceutical compositions thereof are integrin inhibitors that are useful in therapy for a condition, for example, caused by or associated with an infectious agent, shock, pancreatitis, or trauma. The condition can include one or more of pulmonary fibrosis associated with rheumatoid arthritis or progressive familial intrahepatic cholestasis (PFIC).

Abstract: The present invention refers to a controlled release system of phytocannabinoids formulation soluble in aqueous media comprising phytocannabinoids, or derivatives thereof, a non-ionic surfactant and a cross-linked polymer, wherein the pH of the compositions ranges between 4 and 9, and wherein the weight ratio of cannabinoid/hyaluronic acid is 50:1 to 1:50, and the weight ratio cannabinoid/non-ionic surfactant is 1:30 to 1:1. The invention also refers to methods of producing the controlled release system of cannabinoids formulation soluble in aqueous medium and the pharmaceutical, cosmetic and nutraceutical applications thereof. The methods of the present invention allow the cross-linking of hyaluronic acid containing encapsulated or vehiculized phytocannabinoids at neutral pH, avoiding the degradation of the phytocannabinoids and preserving its functionality.

Abstract: The lifting, stabilizing and propelling arrangement for vertical take-off and landing aircraft, uses rotating wings, turbines or lift fans, propellers and stabilizers on the trailing edges of the wings and empennages, centrifugal or tangential turbines applied on the sides of the fuselage, on the inlet and outlet edges of the wings, or centrifugal or tangential turbines on the sides of the fuselage and inside the wings, those that carry the fuselage are fixed and produce only lift and those that go in the wings they rotate with them and produce lift during vertical flight and propulsion during horizontal flight, add some horizontal stabilizing fans at the tips of the wings and others for direction in the vertical empennage.

Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: An apparatus for aircraft anti-icing includes a nozzle body, at least one nozzle extending from the nozzle body, and at least one vane disposed in at least one of the nozzle(s), the at least one vane configured to impart rotational movement of a hot gas moving through the nozzle(s).

Abstract: The machine comprises a solid matrix (1), a deformable body (2) joined to the surface of said matrix (1), a shaping mould (3) and a securing system system (5) for the fibre structure (4). The matrix (1) is a solid element having a functional face, the geometry of which depends on the part to be manufactured. The deformable body (2) has an initial geometry that depends on the geometry to be given to the fibre structure (4). The shaping mould (3) has the geometry to be given to the fibre structure (4) during the process of adaptation to the shaping mould (3), and the shaping mould (3) is located such that the deformable body (2) is located between said shaping mould (3) and the matrix (1).

Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, ?v?1 integrin and ?v?6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: A system for the treatment of materials, to be selected from between materials in a fluid state (1) and particles suspended in a fluid material (1), comprising at least one upper kinematic pair equipped with two mechanical elements (2a, 2b; 2a, 2c), said kinematic pair being in contact with a material in a fluid state (1) or with particles suspended in a fluid material (1); motor means (5) to generate a pre-set relative velocity (v) between the elements (2a, 2b; 2a, 2c) of said kinematic pair, and tensioning means (8) to subject said kinematic pair to a pre-set pressure (P).

Abstract: The machine comprises a solid matrix (1), a deformable body (2) joined to the surface of said matrix (1), a shaping mould (3) and a securing system system (5) for the fibre structure (4). The matrix (1) is a solid element having a functional face, the geometry of which depends on the part to be manufactured. The deformable body (2) has an initial geometry that depends on the geometry to be given to the fibre structure (4). The shaping mould (3) has the geometry to be given to the fibre structure (4) during the process of adaptation to the shaping mould (3), and the shaping mould (3) is located such that the deformable body (2) is located between said shaping mould (3) and the matrix (1).

Abstract: The improvements in the energy capture systems of sea, river and wind currents, characterized in that the turbines are helical in shape and the turns or threads have an inclination close to 45°, of a quarter-round or quarter-circle section and are placed together with the shafts of the generators that are covered by a casing. or aerodynamic nacelle in front of or on the other side of the support mast. The upper area of the mast can rotate with the generator and have an aerodynamic profile. They can be installed attached to one end by means of a cable between the two banks of a river, or in a narrowing of the same, or they can be subject to elements or means of fastening consisting of a mast, tree, or with a chain, fixed to the ground. at the bottom of the sea or river. The turbines drive a generator and electrical conduction cables and a security and warning facility are added.

Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, ?v?1 integrin and ?v?6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: An apparatus for aircraft anti-icing includes a nozzle head including an inner wall and an outer wall, the inner wall defining a through-hole extending through the nozzle, the outer wall circumscribing the inner wall, wherein a plenum is disposed between the inner wall and the outer wall, and a neck extending from the outer wall of the nozzle head, the neck configured to supply a flow of hot gas to the plenum, wherein a maximum width of the inner surface of the neck is less than a maximum width of the through-hole.

Abstract: The germ protection system for vehicles, hospitals, restaurants, schools, nursing homes, lifts and the like uses: a) A system that prevents germs: bacteria, protozoa, viruses or parasites from being breathed in vehicles or closed premises, lifts or the like, blowing or sucking air, b) An independent air installation that applies air conditioning, fed with turbofan engines, to the individual air blowing nozzles in the ceiling or backrest of the compartments of each passenger, c) An independent air installation using compressors that extracts and compresses the outside air, and apply it to the individual air blowing nozzles in the ceiling or backrest of the compartments of each passenger, d) A system that uses an individual installation to replace oxygen system in case of emergency, e) A system that is valid simultaneously for protection against germs and for breathing in case of emergency.

Abstract: The ultralight two track train that does not derail, made up of one or more ultralight wagons and aerodynamic, oval or semi-oval transverse profiles, characterized in that the wagons carry vertical or inclined wheels or pulley wheels in their lower area and supported by the chassis of the wagons, which rest and roll on a pair of vertical or inclined rails, the channels of the pulley wheels are supported and held on the head of circular, semicircular or semi-oval section of the rails, the heads of the rails being trapped with the pulley wheels, adding pairs of wheels that use a common axis, the rails are coupled and fixed tongue and groove to the sleepers or to some monolithic structures or channels, the sleepers are fixed using the track system on concrete slab, using electrical supply means, propellant means and reducing means of the front, rear and lateral resistance of the wagons, adding wheels with permanent magnets or with electromagnets that are attached, or run close and attracted by the rails.

Abstract: A group feed is displayed for a selected group by a private social network service. The group feed displays only threads with unviewed content along with a user actuatable display element that allows the user to switch to a feed that displays all content for the group.