Abstract: The present invention refers to a composition comprising cannabinoid loaded polymer submicroparticles soluble in aqueous media comprising a polyelectrolyte complex formed by a positive charged polymer, selected from chitosan or a derivative thereof, a negative charged polymer selected from hyaluronic acid or a derivative thereof, and a cannabinoid, or a derivative thereof, or a mixture of cannabinoids, or derivatives thereof, and water, wherein the size of the submicroparticles is 600-750 nm, the weight ratio of positive charged polymer/negative charged polymer is 2.6:1-3.8:1, and the weight ratio polymers/cannabinoid is 100:1 to 1:100, wherein the cannabinoids are arranged in hydrophobic patches formed between the positive charged polymer and the negative charged polymer chains. The method of producing said composition and its nutraceutical, pharmaceutical and cosmetic uses are also contemplated.

Abstract: The present invention refers to a controlled release system of phytocannabinoids formulation soluble in aqueous media comprising phytocannabinoids, or derivatives thereof, a non-ionic surfactant and a cross-linked polymer, wherein the pH of the compositions ranges between 4 and 9, and wherein the weight ratio of cannabinoid/hyaluronic acid is 50:1 to 1:50, and the weight ratio cannabinoid/non-ionic surfactant is 1:30 to 1:1. The invention also refers to methods of producing the controlled release system of cannabinoids formulation soluble in aqueous medium and the pharmaceutical, cosmetic and nutraceutical applications thereof. The methods of the present invention allow the cross-linking of hyaluronic acid containing encapsulated or vehiculized phytocannabinoids at neutral pH, avoiding the degradation of the phytocannabinoids and preserving its functionality.