Patents by Inventor Manuel NAPPI

Manuel NAPPI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for labeling nucleic acid
    Patent number: 12703881
    Abstract: The invention provides a method for labeling a nucleic acid comprising N6-methyl adenine. The method comprises forming an alpha-amino radical on the N6-methyl group of N6mAde, and capturing the alpha-amino radical with a radical acceptor comprising a nitrosopyridyl group. The presence of N6mAde in a nucleic acid may then be established by detection of the labeled nucleic acid, or the labeled nucleic acid may be extracted or further modified using the label. Also provided is a method for mapping the position of N6mAde within a target nucleic acid, and probe molecules and kits for use in the method.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: August 11, 2026
    Assignee: CAMBRIDGE ENTERPRISE LIMITED
    Inventors: Manuel Nappi, Alexandre Hofer, Shankar Balasubramanian, Matthew J. Gaunt
  • METHOD FOR LABELING NUCLEIC ACID
    Publication number: 20230416815
    Abstract: The invention provides a method for labeling a nucleic acid comprising N6-methyl adenine. The method comprises forming an alpha-amino radical on the N6-methyl group of N6mAde, and capturing the alpha-amino radical with a radical acceptor comprising a nitrosopyridyl group. The presence of N6mAde in a nucleic acid may then be established by detection of the labeled nucleic acid, or the labeled nucleic acid may be extracted or further modified using the label. Also provided is a method for mapping the position of N6mAde within a target nucleic acid, and probe molecules and kits for use in the method.
    Type: Application
    Filed: September 14, 2021
    Publication date: December 28, 2023
    Inventors: Manuel NAPPI, Alexandre HOFER, Shankar BALASUBRAMANIAN, Matthew J. GAUNT