Patents by Inventor Manuel Perez Vazquez

Manuel Perez Vazquez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLIC PEPTIDES MULTIMERS TARGETING ALPHA-4-BETA-7 INTEGRIN
    Publication number: 20230406884
    Abstract: There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).
    Type: Application
    Filed: June 8, 2023
    Publication date: December 21, 2023
    Inventors: Mohammed Monzur MORSHED, Sai Kumar CHAKKA, Jennifer L. HICKEY, Manuel Perez VAZQUEZ, Andrew ROUGHTON, Adam Paul KAFAL, Narendrakumar B. PATEL
  • COMPOUNDS TARGETING ALPHA4-BETA7 INTEGRIN
    Publication number: 20230295235
    Abstract: Abstract: Compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, are described. The compounds are ?4?7 antagonists and are useful in the prevention or treatment of inflammatory conditions and/or autoimmune diseases, especially inflammatory bowel disease.
    Type: Application
    Filed: June 25, 2021
    Publication date: September 21, 2023
    Inventors: Andrew Roughton, Narendrakumar Patel, Adam Paul Kafal, Manuel Perez Vazquez, Jennifer Hickey, Sai Kumar Chakka, Monzur Morshed
  • Cyclic peptides multimers targeting ?-4-?-7 integrin
    Patent number: 11713338
    Abstract: There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: August 1, 2023
    Assignee: Zealand Pharma A/S
    Inventors: Mohammed Monzur Morshed, Sai Kumar Chakka, Jennifer L. Hickey, Manuel Perez Vazquez, Andrew Roughton, Adam Paul Kafal, Narendrakumar B. Patel
  • Homodetic cyclic peptides targeting alpha-4-beta-7 integrin
    Patent number: 11286281
    Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly cyclic peptide antagonists, such as compounds of formula (I).
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: March 29, 2022
    Assignee: Zealand Pharma A/S
    Inventors: Manuel Perez Vazquez, M. Monzur Morshed, Adam Paul Kafal, Jennifer L. Hickey, Andrew Roughton
  • CYCLIC PEPTIDES MULTIMERS TARGETING ALPHA-4-BETA-7 INTEGRIN
    Publication number: 20210324007
    Abstract: There is described herein, multimers comprising plurality of compounds covalently linked together, the compounds independently being of formula (I).
    Type: Application
    Filed: April 19, 2021
    Publication date: October 21, 2021
    Inventors: Mohammed Monzur MORSHED, Sai Kumar CHAKKA, Jennifer L. HICKEY, Manuel Perez VAZQUEZ, Andrew ROUGHTON, Adam Paul KAFAL, Narendrakumar B. PATEL
  • CYCLIC PEPTIDES TARGETING ALPHA-4-BETA-7 INTEGRIN
    Publication number: 20210300932
    Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; —C?O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C?O— is a peptide.
    Type: Application
    Filed: March 26, 2021
    Publication date: September 30, 2021
    Inventors: Manuel Perez VAZQUEZ, M. Monzur MORSHED, Jennifer L. HICKEY, Adam Paul KAFAL, James GILLARD, Narendra PATEL, Sai Kumar CHAKKA, Andrew L. ROUGHTON, Marc-André POUPART, Gaoqiang YANG
  • Cyclic peptides multimers targeting alpha-4-beta-7 integrin
    Patent number: 11111273
    Abstract: There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: September 7, 2021
    Assignee: Zealand Pharma A/S
    Inventors: Mohammed Monzur Morshed, Sai Kumar Chakka, Jennifer L. Hickey, Manuel Perez Vazquez, Andrew Roughton, Adam Paul Kafal, Narendrakumar B. Patel
  • Cyclic peptides targeting alpha-4-beta-7 integrin
    Patent number: 11072616
    Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; —C?O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C?O— is a peptide.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: July 27, 2021
    Assignees: Universite de Montreal, Zealand Pharma A/S
    Inventors: Manuel Perez Vazquez, M. Monzur Morshed, Jennifer L. Hickey, Adam Paul Kafal, James Gillard, Narendra Patel, Sai Kumar Chakka, Andrew L. Roughton, Marc-André Poupart, Gaoqiang Yang
  • Fragment synthesis of substituted cyclic peptides
    Patent number: 11046695
    Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: June 29, 2021
    Assignees: Zealand Pharma A/S, Universite de Montreal
    Inventors: Manuel Perez Vazquez, M. Monzur Morshed, Jennifer L. Hickey, Marc-André Poupart, Gaoqiang Yang, James Gillard, Adam Paul Kafal, Andrew L. Roughton
  • Fragment synthesis of substituted cyclic peptides
    Patent number: 10981921
    Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: April 20, 2021
    Assignee: Zealand Pharma A/S
    Inventors: Manuel Perez Vazquez, M. Monzur Morshed, Jennifer L. Hickey, Marc-André Poupart, Gaoqiang Yang, James Gillard, Adam Paul Kafal, Andrew L. Roughton
  • FRAGMENT SYNTHESIS OF CYCLIC PEPTIDES
    Publication number: 20200361944
    Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.
    Type: Application
    Filed: August 4, 2020
    Publication date: November 19, 2020
    Inventors: Manuel Perez VAZQUEZ, M. Monzur MORSHED, Jennifer L. HICKEY, Marc-André POUPART, Gaoqiang YANG, James GILLARD, Adam Paul KAFAL, Andrew L. ROUGHTON
  • CYCLIC PEPTIDES MULTIMERS TARGETING ALPHA-4-BETA-7 INTEGRIN
    Publication number: 20200216501
    Abstract: There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).
    Type: Application
    Filed: November 10, 2017
    Publication date: July 9, 2020
    Inventors: Mohammed Monzur MORSHED, Sai Kumar CHAKKA, Jennifer L. HICKEY, Manuel Perez VAZQUEZ, Andrew ROUGHTON, Adam Paul KAFAL, Narendrakumar B. PATEL
  • Cyclic Peptides Targeting Alpha-4-Beta-7 Integrin
    Publication number: 20200165300
    Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; —C?O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C?O— is a peptide.
    Type: Application
    Filed: November 14, 2016
    Publication date: May 28, 2020
    Inventors: Manuel Perez Vazquez, M. Monzur Morshed, Jennifer L. Hickey, Adam Paul Kafal, James Gillard, Narendra Patel, Sai Kumar Chakka, Andrew L. Roughton, Marc-André Poupart, Gaoqiang Yang
  • HOMODETIC CYCLIC PEPTIDES TARGETING ALPHA-4-BETA-7 INTEGRIN
    Publication number: 20200095285
    Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly cyclic peptide antagonists, such as compounds of formula (I).
    Type: Application
    Filed: May 10, 2018
    Publication date: March 26, 2020
    Inventors: Manuel Perez VAZQUEZ, M. Monzur MORSHED, Adam Paul KAFAL, Jennifer L. HICKEY, Andrew ROUGHTON
  • Fragment Synthesis of Cyclic Peptides
    Publication number: 20190077805
    Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.
    Type: Application
    Filed: November 14, 2016
    Publication date: March 14, 2019
    Inventors: Manuel Perez Vazquez, M. Monzur Morshed, Jennifer L. Hickey, Marc-André Poupart, Gaoqiang Yang, James Gillard, Adam Paul Kafal, Andrew L. Roughton