Patents by Inventor Manuel Rubio
Manuel Rubio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240091348Abstract: The present invention provides pharmaceutical compositions comprising particles formed by synthetic polymers and polyinosinic-polycytidylic acid and compositions comprising polyinosinic-polycytidylic acid having a specific size distribution, that are adapted for parenteral administration, in particular for subcutaneous, intramuscular, or intravenous injection or infusion. These formulations can be used in a variety of clinical applications, for instance, in methods for administering vaccines or for treating or preventing cancer. The disclosed formulations can be used in combination with conventional therapies such as radiation therapy, chemotherapy, immunotherapy, cryotherapy, tumor ablation and/or anti-cancer drugs or other standard-of-care medical treatments.Type: ApplicationFiled: July 11, 2023Publication date: March 21, 2024Applicant: HIGHLIGHT THERAPEUTICS, S.L.Inventors: Juan-Manuel FUNES, Mercedes POZUELO RUBIO, Marisol Quintero Ortiz
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Publication number: 20240091350Abstract: The present invention provides pharmaceutical compositions comprising polyinosinic-polycytidylic acid, in particular using particles formed by synthetic polymers, that are adapted for parenteral administration, such as for subcutaneous, intramuscular, or intravenous injection, or infusion. The formulations disclosed herein may be used in a variety of clinical applications, for instance, in methods for administering cell-, peptide-, or nucleic acid-based cancer vaccines or for administering other agents to treat or prevent cancer. The disclosed formulations may also be used in combination with conventional therapies such as radiation therapy, chemotherapy, immunotherapy, cryotherapy, tumor ablation and/or anti-cancer drugs or other standard-of-care medical treatments.Type: ApplicationFiled: September 18, 2023Publication date: March 21, 2024Applicant: HIGHLIGHT THERAPEUTICS, S.L.Inventors: Juan-Manuel FUNES, Mercedes POZUELO RUBIO, Marisol QUINTERO ORTIZ
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Patent number: 11598773Abstract: Method and compositions using transition metal salts and/or ammonium chloride to liberate toxins and other molecules from cyanobacteria, useful for assaying for total cyanobacterial toxins in lakes, reservoirs and other waters.Type: GrantFiled: May 19, 2021Date of Patent: March 7, 2023Assignee: Gold Standard Diagnostics Horsham, Inc.Inventors: Fernando Manuel RUbio, Lisa Marie Kamp
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Patent number: 11035856Abstract: Method and compositions using transition metal salts and/or ammonium chloride to liberate toxins and other molecules from cyanobacteria, useful for assaying for total cyanobacterial toxins in lakes, reservoirs and other waters.Type: GrantFiled: April 2, 2020Date of Patent: June 15, 2021Assignee: Abraxis, Inc.Inventors: Fernando Manuel Rubio, Lisa Marie Kamp
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Patent number: 10941428Abstract: The invention relates to reagents and methods that allow the expression of an active NifB protein in yeast and plants under aerobic conditions. The active NifB protein allows the in vitro synthesis of the FeMo cofactor (FeMo-co) which leads to the subsequent apo-NifDK activation and generation of active nitrogenase.Type: GrantFiled: October 16, 2018Date of Patent: March 9, 2021Assignee: UNIVERSIDAD POLITÉCNICA DE MADRIDInventors: Luis Manuel Rubio Herrero, Stefan Burén, Xi Jiang, Carlos Echavarri Erasun, Gema López Torrejón
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Patent number: 10641769Abstract: Method and compositions using transition metal salts and/or ammonium chloride to liberate toxins and other molecules from cyanobacteria, useful for assaying for total cyanobacterial toxins in lakes, reservoirs and other waters.Type: GrantFiled: June 6, 2019Date of Patent: May 5, 2020Assignee: Abraxis, Inc.Inventors: Fernando Manuel Rubio, Lisa Marie Kamp
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Publication number: 20200080117Abstract: The invention relates to reagents and methods that allow the expression of an active NifB protein in yeast and plants under aerobic conditions. The active NifB protein allows the in vitro synthesis of the FeMo cofactor (FeMo-co) which leads to the subsequent apo-NifDK activation and generation of active nitrogenase.Type: ApplicationFiled: October 16, 2018Publication date: March 12, 2020Inventors: Luis Manuel RUBIO HERRERO, Stefan BURÉN, Xi JIANG, Carlos ECHAVARRI ERASUN, Gema LÓPEZ TORREJÓN
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Patent number: 10444217Abstract: Method and compositions using transition metal salts and/or ammonium chloride to liberate toxins and other molecules from cyanobacteria, useful for assaying for total cyanobacterial toxins in lakes, reservoirs and other waters.Type: GrantFiled: August 3, 2017Date of Patent: October 15, 2019Assignee: Abraxis, Inc.Inventors: Fernando Manuel Rubio, Lisa Marie Kamp
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Patent number: 10338067Abstract: Method and compositions using transition metal salts and/or ammonium chloride to liberate toxins and other molecules from cyanobacteria, useful for assaying for total cyanobacterial toxins in lakes, reservoirs and other waters.Type: GrantFiled: July 14, 2013Date of Patent: July 2, 2019Assignee: Abraxis, Inc.Inventors: Fernando Manuel Rubio, Lisa Marie Kamp
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Patent number: 9739777Abstract: Method and compositions using transition metal salts and/or ammonium chloride to liberate toxins and other molecules from cyanobacteria, useful for assaying for total cyanobacterial toxins in lakes, reservoirs and other waters.Type: GrantFiled: July 3, 2010Date of Patent: August 22, 2017Assignee: Abraxis Inc.Inventors: Fernando Manuel Rubio, Lisa Marie Kamp
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Patent number: 9057095Abstract: The present invention provides a kit and a method of testing for carbamates in amine cured epoxies. The method and kit are based on the use of an enzyme that is inhibited by carbamates. A specific embodiment of the kit includes acetylthiocholine (ATC), dithio-bis (2-nitrobenzoic acid) (DTNB), and acetyl-cholinesterase (ACh-E). In the corresponding method embodiment, the method comprises the steps of collecting carbamates from the epoxy, adding the collected carbamates to a solution, adding acetyl-cholinesterase (ACh-E) to the solution, adding acetylthiocholine (ATC) to the solution, adding dithio-bis (2-nitrobenzoic acid) (DTNB) to the solution, and ultimately measuring the intensity of the yellow color of the solution.Type: GrantFiled: January 13, 2012Date of Patent: June 16, 2015Assignee: Abraxis LLCInventors: Melissa Tuchscherer, Perry Kilpatrick, Richard Slawecki, Fernando Manuel Rubio
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Patent number: 8628326Abstract: Dental prosthesis to be fixed on implants (103) is arranged in a dental arch (100), completely or partially edentulous. The prosthesis (1) includes a primary structure (200) which is configured to be screwed on the implants (103) of the dental arch (100) and which has primary inserts (410, 420, 430, 440); and a secondary structure (300) which is configured to support a reproduction (104) of the teeth and of the gum of the dental arch (100) and which has secondary inserts (510, 520, 530, 540). The primary inserts (410, 420, 430, 440) and the secondary inserts (510, 520, 530, 540) are configured to work in collaboration and allow the coupling of the secondary structure (300) on the primary structure (200) through a vestibular insertion.Type: GrantFiled: January 14, 2011Date of Patent: January 14, 2014Assignee: Justo Manuel Rubio Cebria, S.L.Inventor: Justo Manuel Rubio Cebriá
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Patent number: 8394596Abstract: Antibodies against ?-N-methylamino-L-alanine (“BMAA”) their production, use and related kits; also the immunogens and methods used to obtain the antibodies.Type: GrantFiled: August 14, 2012Date of Patent: March 12, 2013Assignee: Abraxis LLCInventors: Fernando Manuel Rubio, Daniel Robert Rubio
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Publication number: 20110177476Abstract: Dental prosthesis to be fixed on implants (103) is arranged in a dental arch (100), completely or partially edentulous. The prosthesis (1) includes a primary structure (200) which is configured to be screwed on the implants (103) of the dental arch (100) and which has primary inserts (410, 420, 430, 440); and a secondary structure (300) which is configured to support a reproduction (104) of the teeth and of the gum of the dental arch (100) and which has secondary inserts (510, 520, 530, 540). The primary inserts (410, 420, 430, 440) and the secondary inserts (510, 520, 530, 540) are configured to work in collaboration and allow the coupling of the secondary structure (300) on the primary structure (200) through a vestibular insertion.Type: ApplicationFiled: January 14, 2011Publication date: July 21, 2011Applicant: JUSTO MANUEL RUBIO CEBRIA, S.L.Inventor: Justo Manuel Rubio Cebriá
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Publication number: 20070184175Abstract: A bioprocess and apparatus for the continuous production of novel masa and whole-corn flours as cereal-base and functional-food ingredients. The bioprocess includes providing a fine grind fraction of corn kernel; combining the fine grind fraction of corn kernel with at least one endoamylase to produce an enzyme-added fine grind; moist-heat precooking the enzyme-added fine grind to obtain a pre-cooked enzyme-added fine grind; low-moisture conditioning the precooked enzyme-added fine grind to partially hydrolyze starchy endosperm and swell starch and aleurone-bran granules to produce enzymatically conditioned corn kernel particles; and_milling the conditioned corn kernel particles to obtain flour comprising a fine grind portion of the conditioned corn kernel particle.Type: ApplicationFiled: December 21, 2006Publication date: August 9, 2007Inventors: Felipe Rubio, Manuel Rubio, Roberto Contreras, Francisco Sosa, J. Fernando Ramirez, Rodrigo Massu
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Publication number: 20070148318Abstract: A process and apparatus for the continuous production of masa and whole-corn flour for grain-based foods, includes a preconditioning of clean corn, grinding the moisturized corn to produce fine and coarse grind fractions, sieving the fine grind and aspirating from both fractions a light-bran fraction as animal feed, remilling the coarse grind for further bran extraction and admixing the sifted fine grind with lime to produce a limed grind, low-moisture precooking of a stream of limed corn particles in another stream of saturated steam to obtain a partial starch pregelatinization and protein denaturation degree, venting and separating the moist-heated corn particles, conditioning the segregated fine grind to soften and swell the endosperm, germ and bran fractions, hot-air drying the tempered fine grind and stabilizing for extended shelf-life, cooling the dried fine grind with clean air; grinding the agglomerated particles, classifying and separating the fine grind produced from the coarse grind.Type: ApplicationFiled: December 22, 2005Publication date: June 28, 2007Inventors: Felipe Rubio, Manuel Rubio, Roberto Contreras, Francisco Sosa, J. Ramirez
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Publication number: 20060251791Abstract: A process and apparatus for the continuous production of pregelatinized corn flours for dairy-based and cereal-based foods, includes an acid precooking with a sodium metabisulfite, or sodium hydrogen sulfite or sodium sulfite solution as a food processing aid for partial hydrolysis of insoluble fiber, starch and protein, along with a controlled pregelatinization and denaturation, kernel washing, stabilizing moisture content for grinding, milling and drying preconditioned kernel to produce a partial gelatinization, cooling and drying the dry-ground particle, separation and recovery of the ultrafine grind from the coarser grind while the latter is further aspirated to remove a light corn bran and further reground to produce bran flour, remilling and sieving the isolated coarser grind to obtain fine corn flour for cereal-based foods, and admixing only fine flour with lime to produce a masa flour. An ultrafine corn flour is used as an aid or adjuvant flour for dairy-based foods.Type: ApplicationFiled: May 5, 2005Publication date: November 9, 2006Inventors: Felipe Rubio, Manuel Rubio, Francisco Arroyo, Rick Norton, Roberto Contreras, Miguel Arce, J. Ramirez
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Publication number: 20060024407Abstract: Precooked and partially-debranned corn flour is continuously produced by an enzymatic precooking using a commercial blend of xylanase, endoamylase and endoprotease as a processing aid. The low-temperature and neutral-pH precooking with an endoenzyme solution effected a partial bran hydrolysis while avoiding excessive pregelatinization, reduced washing and corn solid loss in wastewater. Moisture content is then stabilized, followed by milling and drying at a high-temperature and short-time to produce a controlled gelatinization and denaturation in the ground kernel, cooling and further drying the dried-ground particle. A fine particle size or flour is separated and recovered from the coarser particle which is also segregated to isolate a partially hydrolysed bran fraction for integral flour or animal feed diet, remilling and sieving the coarser particle to produce an instant corn flour for snack, and admixing the fine particle with lime to obtain a masa flour for tortilla and other corn foods.Type: ApplicationFiled: October 27, 2004Publication date: February 2, 2006Inventors: Felipe Rubio, Manuel Rubio, Roberto Contreras, J. Ramirez, Rodrigo Massu