Patents by Inventor Manuel Sarasa Barrio

Manuel Sarasa Barrio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220184178
    Abstract: A composition includes aluminum hydroxide gel and a conjugate of at least one CysA13(33-40) peptide linked to the keyhole limpet hemocyanin (KLH). Maleimidobutyric acid Nhydroxysuccinimide ester (SM) serves as cross-linking agent. The composition can produce an effective and specific immune response against A?40. The antibodies produced are specific for A?40 without significantly binding to A?42. The composition can increase the response against A?40 compared with the response produced by other conjugates that include CysA?(33-40) peptide and KLH, and are bound or conjugated by other crosslinking agents.
    Type: Application
    Filed: February 24, 2022
    Publication date: June 16, 2022
    Inventor: Manuel SARASA BARRIO
  • Publication number: 20210214394
    Abstract: The invention relates to antibodies which are used in the preparation of a medicament for the treatment of Alzheimer's disease. More specifically, the invention relates to the use of an antibody specifically recognizing any one of the predominant variants of the amyloid beta peptide, A?40 and A?42, in the preparation of a medicament that is used to prevent and/or treat Alzheimer's disease.
    Type: Application
    Filed: March 26, 2021
    Publication date: July 15, 2021
    Applicant: ARACLON BIOTECH, S.L.
    Inventor: Manuel SARASA BARRIO
  • Publication number: 20210011032
    Abstract: The invention relates to methods for the diagnostic of a neurodegenerative disease, for the detection of a stage prior to a neurodegenerative disease or for distinguishing neurodegenerative disease from a stage prior to a neurodegenerative disease based on the level of certain pools of amyloid beta peptides which are either bound to plasma components or bound to blood cells as well as on certain calculated parameters which are obtained by an arithmetic combination of one or more of the amyloid peptide levels. The invention relates as well to kits for carrying out the above method.
    Type: Application
    Filed: August 5, 2020
    Publication date: January 14, 2021
    Applicant: ARACLON BIOTECH, S.L.
    Inventor: José Manuel Sarasa Barrio
  • Publication number: 20200246430
    Abstract: A composition includes aluminum hydroxide gel and a conjugate of at least one CysA13(33-40) peptide linked to the keyhole limpet hemocyanin (KLH). Maleimidobutyric acid Nhydroxysuccinimide ester (SM) serves as cross-linking agent. The composition can produce an effective and specific immune response against A?40. The antibodies produced are specific for A?40 without significantly binding to A?42. The composition can increase the response against A?40 compared with the response produced by other conjugates that include CysA?(33-40) peptide and KLH, and are bound or conjugated by other crosslinking agents.
    Type: Application
    Filed: April 22, 2020
    Publication date: August 6, 2020
    Inventor: Manuel SARASA BARRIO
  • Publication number: 20200140488
    Abstract: The invention relates to antibodies which are used in the preparation of a medicament for the treatment of Alzheimer's disease. More specifically, the invention relates to the use of an antibody specifically recognizing any one of the predominant variants of the amyloid beta peptide, A?40 and A?42, in the preparation of a medicament that is used to prevent and/or treat Alzheimer's disease.
    Type: Application
    Filed: January 16, 2020
    Publication date: May 7, 2020
    Applicant: ARACLON BIOTECH, S.L.
    Inventor: Manuel SARASA BARRIO
  • Publication number: 20190178899
    Abstract: The invention relates to immunoassays which allow the detection of polypeptides in samples with a higher sensitivity than assays of the state of the art. The invention also relates to kits which provide the components needed for carrying out said immunoassays.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 13, 2019
    Inventor: J. Manuel Sarasa Barrio
  • Publication number: 20190030127
    Abstract: A composition includes aluminum hydroxide gel and a conjugate of at least one CysA13(33-40) peptide linked to the keyhole limpet hemocyanin (KLH). Maleimidobutyric acid Nhydroxysuccinimide ester (SM) serves as cross-linking agent. The composition can produce an effective and specific immune response against A?40. The antibodies produced are specific for A?40 without significantly binding to A?42. The composition can increase the response against A?40 compared with the response produced by other conjugates that include CysA?(33-40) peptide and KLH, and are bound or conjugated by other crosslinking agents.
    Type: Application
    Filed: August 14, 2018
    Publication date: January 31, 2019
    Inventor: Manuel SARASA BARRIO
  • Patent number: 9863961
    Abstract: The invention relates to the field of immunoassays which allow the detection of A? 17 peptides by virtue of the use of an anti-A? 17 antibody and a kit and method using said antibody. The invention also relates to a method for diagnosing or distinguishing between different stages of a neurodegenerative disease.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: January 9, 2018
    Assignee: ARACLON BIOTECH, S.L.
    Inventor: Manuel Sarasa Barrio
  • Publication number: 20170260234
    Abstract: The invention relates to antibodies which are used in the preparation of a medicament for the treatment of Alzheimer's disease. More specifically, the invention relates to the use of an antibody specifically recognizing any one of the predominant variants of the amyloid beta peptide, A?40 and A?42, in the preparation of a medicament that is used to prevent and/or treat Alzheimer's disease.
    Type: Application
    Filed: May 23, 2017
    Publication date: September 14, 2017
    Inventor: Manuel SARASA BARRIO
  • Publication number: 20160195548
    Abstract: The invention relates to the field of immunoassays which allow the detection of A?17 peptides by virtue of the use of an anti-A?17 antibody and a kit and method using said antibody. The invention also relates to a method for diagnosing or distinguishing between different stages of a neurodegenerative disease.
    Type: Application
    Filed: December 22, 2015
    Publication date: July 7, 2016
    Applicant: ARACLON BIOTECH, S.L.
    Inventor: Manuel Sarasa Barrio
  • Patent number: 9255932
    Abstract: The invention relates to the field of immunoassays which allow the detection of A?17 peptides by virtue of the use of an anti-A?17 antibody and a kit and method using said antibody. The invention also relates to a method for diagnosing or distinguishing between different stages of a neurodegenerative disease.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: February 9, 2016
    Assignee: Aracion Biotech, S.L.
    Inventor: Manuel Sarasa Barrio
  • Patent number: 9163062
    Abstract: The invention provides conjugates comprising albumin and a peptide derived from the C-terminal region of amyloid beta peptide, as well as uses thereof for the treatment of diseases characterized by the deposition of amyloid proteins and, in particular, for the treatment of Alzheimer's disease.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: October 20, 2015
    Assignee: Aracion Biotech S.L.
    Inventor: J. Manuel Sarasa Barrio
  • Patent number: 9023991
    Abstract: The invention provides conjugates comprising albumin and a peptide derived from the C-terminal region of amyloid beta peptide, as well as uses thereof for the treatment of diseases characterized by the deposition of amyloid proteins and, in particular, for the treatment of Alzheimer's disease.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: May 5, 2015
    Assignee: Araclon Biotech B.L.
    Inventor: J. Manuel Sarasa Barrio
  • Publication number: 20140086945
    Abstract: The invention provides conjugates comprising albumin and a peptide derived from the C-terminal region of amyloid beta peptide, as well as uses thereof for the treatment of diseases characterized by the deposition of amyloid proteins and, in particular, for the treatment of Alzheimer's disease.
    Type: Application
    Filed: September 20, 2013
    Publication date: March 27, 2014
    Applicant: ARACLON BIOTECH S.L.
    Inventor: J. Manuel SARASA BARRIO
  • Publication number: 20140044725
    Abstract: The invention relates to antibodies which are used in the preparation of a medicament for the treatment of Alzheimer's disease. More specifically, the invention relates to the use of an antibody specifically recognizing any one of the predominant variants of the amyloid beta peptide, A?40 and A?42, in the preparation of a medicament that is used to prevent and/or treat Alzheimer's disease.
    Type: Application
    Filed: September 13, 2013
    Publication date: February 13, 2014
    Applicant: ARACLON BIOTECH, S.L.
    Inventor: MANUEL SARASA BARRIO
  • Publication number: 20140024054
    Abstract: The invention relates to the field of immunoassays which allow the detection of A? 17 peptides by virtue of the use of an anti-A? 17 antibody and a kit and method using said antibody. The invention also relates to a method for diagnosing or distinguishing between different stages of a neurodegenerative disease.
    Type: Application
    Filed: April 3, 2012
    Publication date: January 23, 2014
    Applicant: ARACLON BIOTECH, S.L.
    Inventor: Manuel Sarasa Barrio
  • Publication number: 20120264642
    Abstract: The invention relates to methods for the diagnostic of a neurodegenerative disease, for the detection of a stage prior to a neurodegenerative disease or for distinguishing neurodegenerative disease from a stage prior to a neurodegenerative disease based on the level of certain pools of amyloid beta peptides which are either bound to plasma components or bound to blood cells as well as on certain calculated parameters which are obtained by an arithmetic combination of one or more of the amyloid peptide levels. The invention relates as well to kits for carrying out the above method.
    Type: Application
    Filed: December 13, 2010
    Publication date: October 18, 2012
    Applicant: ARACLON BIOTECH, S.L.
    Inventor: José Manuel Sarasa Barrio
  • Publication number: 20120130049
    Abstract: The invention provides conjugates comprising albumin and a peptide derived from the C-terminal region of amyloid beta peptide, as well as uses thereof for the treatment of diseases characterized by the deposition of amyloid proteins and, in particular, for the treatment of Alzheimer's disease.
    Type: Application
    Filed: May 26, 2010
    Publication date: May 24, 2012
    Inventor: J. Manuel Sarasa Barrio
  • Publication number: 20110262458
    Abstract: The invention relates to antibodies which are used in the preparation of a medicament for the treatment of Alzheimer's disease. More specifically, the invention relates to the use of an antibody specifically recognizing any one of the predominant variants of the amyloid beta peptide, Ab40 and Ab42, in the preparation of a medicament that is used to prevent and/or treat Alzheimer's disease.
    Type: Application
    Filed: March 17, 2011
    Publication date: October 27, 2011
    Applicant: ARACLON BIOTECH, S.L.
    Inventor: MANUEL SARASA BARRIO
  • Publication number: 20090162362
    Abstract: The invention relates to antibodies which are used in the preparation of a medicament for the treatment of Alzheimer's disease. More specifically, the invention relates to the use of an antibody specifically recognizing any one of the predominant variants of the amyloid beta peptide, Ab40 and Ab42, in the preparation of a medicament that is used to prevent and/or treat Alzheimer's disease.
    Type: Application
    Filed: May 3, 2004
    Publication date: June 25, 2009
    Inventor: Manuel Sarasa Barrio