Patents by Inventor Manuel Scanu

Manuel Scanu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates in the synthesis of cephalosporin compounds
    Patent number: 10941161
    Abstract: Described herein are crystalline forms of a compound of formula (III?), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: March 9, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
  • INTERMEDIATES IN THE SYNTHESIS OF CEPHALOSPORIN COMPOUNDS
    Publication number: 20190225624
    Abstract: Described herein are crystalline forms of a compound of formula (III?), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.
    Type: Application
    Filed: March 4, 2019
    Publication date: July 25, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
  • Intermediates in the synthesis of cephalosporin compounds
    Patent number: 10221196
    Abstract: Described herein are crystalline forms of a compound of formula (II?), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (II?): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: March 5, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
  • Synthesis of cephalosporin compounds
    Patent number: 10214543
    Abstract: Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: February 26, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, Michele Benotti
  • SYNTHESIS OF CEPHALOSPORIN COMPOUNDS
    Publication number: 20180170949
    Abstract: Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 21, 2018
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Kristos Adrian MOSHOS, Valdas JURKAUSKAS, Giovanni FOGLIATO, Manuel SCANU, Michele BENOTTI
  • INTERMEDIATES IN THE SYNTHESIS OF CEPHALOSPORIN COMPOUNDS
    Publication number: 20170226126
    Abstract: Described herein are crystalline forms of a compound of formula (III?), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (III?): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.
    Type: Application
    Filed: August 14, 2015
    Publication date: August 10, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
  • Reactions of thiadiazolyl-oximinoacetic acid derivative compounds
    Patent number: 9695196
    Abstract: This disclosure relates to an improved synthesis of cephalosporin antibiotic compounds such as ceftolozane, and compositions and methods of use thereof. Thiadiazolyl-oximinoacetic acid compounds such as TATD can be reacted to yield the activated thiadiazolyl-oximinoacetic acid methanesulfonate ester compounds useful in the manufacture of cephalosporin antibiotic compounds.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: July 4, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Manuel Scanu, Michele Benotti
  • REACTIONS OF THIADIAZOLYL-OXIMINOACETIC ACID DERIVATIVE COMPOUNDS
    Publication number: 20170129906
    Abstract: This disclosure relates to an improved synthesis of cephalosporin antibiotic compounds such as ceftolozane, and compositions and methods of use thereof. Thiadiazolyl-oximinoacetic acid compounds such as TATD can be reacted to yield the activated thiadiazolyl-oximinoacetic acid methanesulfonate ester compounds useful in the manufacture of cephalosporin antibiotic compounds.
    Type: Application
    Filed: June 19, 2015
    Publication date: May 11, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Kristos Adrian Moshos, Valdas Jukauskas, Manuel Scanu, Michele Benotti