Patents by Inventor Manuel Serrano

Manuel Serrano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230000794
    Abstract: Feed additive including sodium carbonate feed additive polyphenol particles can be fed to animals to reduce methane or carbon dioxide emission. The feed additive polyphenol particles can be prepared by reacting phenols with sodium percarbonate (2Na2CO3.3H2O2) in a solution of water, a peroxidase and a dispersing agent. The sodium percarbonate can be dissolved in the water solution to generate sodium and carbonate ions, which can be incorporated to the polyphenol particles for assisting the animals in digesting the feed additive. The dispersing agent can be used to limit the sizes of the particles to facilitate the consumption of the feed additive by the animals.
    Type: Application
    Filed: September 12, 2022
    Publication date: January 5, 2023
    Inventor: Manuel Serrano
  • Patent number: 11439604
    Abstract: Feed additive including sodium carbonate feed additive polyphenol particles can be fed to animals to reduce methane or carbon dioxide emission. The feed additive polyphenol particles can be prepared by reacting phenols with sodium percarbonate (2Na2CO3.3H2O2) in a solution of water, a peroxidase and a dispersing agent. The sodium percarbonate can be dissolved in the water solution to generate sodium and carbonate ions, which can be incorporated to the polyphenol particles for assisting the animals in digesting the feed additive. The dispersing agent can be used to limit the sizes of the particles to facilitate the consumption of the feed additive by the animals.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: September 13, 2022
    Inventor: Manuel Serrano
  • Publication number: 20170014443
    Abstract: Compositions containing hemicelluloses, citric acid and glucose syrup, fructose or sucrose in combination with polyphenols and prebiotics, methods of preparing the compositions, and methods of treating humans or animals with the composition are provided. Also provided is a method for increasing growth rate, improving feed efficiency and decreasing scour after weaning in an animal by administering an effective amount of the composition to the animal. The prebiotics preferably are not consumed by human alimentary enzymes or harmful bacteria, such as putrefactive or pathogenic bacteria, and are consumed by beneficial bacteria, such as bifidobacteria, in the gastrointestinal tract. The polyphenols preferably decrease the amount of harmful bacteria in the gastrointestinal tract. The compositions can optionally contain a carrier or be used as a feed addition and are administered to humans or other animals in an amount sufficient to treat the gastrointestinal disorder.
    Type: Application
    Filed: July 19, 2016
    Publication date: January 19, 2017
    Inventor: Manuel Serrano
  • Patent number: 9526754
    Abstract: Combinations of dried plants can be prepared to form a herbal medicine, including reacting, in hydrogen peroxide, a combination of the extraction of pomegranate rinds (Punica Granatum), green tea extract (Camellia Sinensis), guava leaves, (Psididum Guajava) and jamun (Sysygum Cuminni). The herbal medicine can be used to treat and cure diarrhea, as antibacterial, anti-inflammatory and wound healing.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: December 27, 2016
    Inventor: Manuel Serrano
  • Publication number: 20130267029
    Abstract: This invention provides methods and compositions for increasing the efficiency of obtaining pluripotent stem cells, the method comprising expressing a 133p53 in cells that are being re-programmed to obtain pluripotent cells. The invention also provides method of inhibiting the proliferation of cancer stem cells, the method comprising suppressing expression of 133p53 in the cells.
    Type: Application
    Filed: September 30, 2011
    Publication date: October 10, 2013
    Applicants: Fundacion Centro Nacional de Ivestigaciones Oncologicas, Carlos, The Government of the United States of America as Represented by the Secretary of The Dept. of Healt
    Inventors: Curtis C. Harris, Izumi Horikawa, Kaori Fujita, Abdul M. Mondal, Kye-Yoon Park, Sharon R. Pine, Manuel Serrano
  • Patent number: 8187194
    Abstract: A method of mounting a transducer to a driveshaft which eliminates the need for a transducer housing, the improved method directly attaches the transducer to a rigid distal tip of a driveshaft which is part of a rotatable imaging core of a catheter assembly. The method contemplates heat treating the distal tip of the driveshaft to make it rigid, machining the distal tip to be dimensioned to hold the transducer, and attaching the transducer to the distal tip by clamping, crimping, or an adhesive.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: May 29, 2012
    Assignee: Boston Scientific SciMed, Inc.
    Inventors: Manuel Serrano, James D. Koger
  • Publication number: 20100274140
    Abstract: A method of mounting a transducer to a driveshaft which eliminates the need for a transducer housing, the improved method directly attaches the transducer to a rigid distal tip of a driveshaft which is part of a rotatable imaging core of a catheter assembly. The method contemplates heat treating the distal tip of the driveshaft to make it rigid, machining the distal tip to be dimensioned to hold the transducer, and attaching the transducer to the distal tip by clamping, crimping, or an adhesive.
    Type: Application
    Filed: June 3, 2010
    Publication date: October 28, 2010
    Applicant: SCIMED LIFE SYSTEMS, INC.
    Inventors: Manuel Serrano, James D. Koger
  • Patent number: 7762955
    Abstract: A method of mounting a transducer to a driveshaft which eliminates the need for a transducer housing, the improved method directly attaches the transducer to a rigid distal tip of a driveshaft which is part of a rotatable imaging core of a catheter assembly. The method contemplates heat treating the distal tip of the driveshaft to make it rigid, machining the distal tip to be dimensioned to hold the transducer, and attaching the transducer to the distal tip by clamping, crimping, or an adhesive.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: July 27, 2010
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Manuel Serrano, James D. Koger
  • Patent number: 7691632
    Abstract: The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a family of cell-cycle regulatory proteins (“CCR-proteins”). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth. The present invention comprises antibodies directed to such CCR-proteins. The present invention is directed to a kit for detecting the level of cyclin-dependent kinase inhibitor p16 gene expression comprising antibodies directed to a p16 protein.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: April 6, 2010
    Assignee: Cold Spring Harbor Laboratory
    Inventors: David H. Beach, Douglas J. Demetrick, Manuel Serrano, Gregory J. Hannon
  • Publication number: 20090170098
    Abstract: The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a family of cell-cycle regulatory proteins (“CCR-proteins”). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth. The present invention comprises antibodies directed to such CCR-proteins. The present invention is directed to a kit for detecting the level of cyclin-dependent kinase inhibitor p16 gene expression comprising antibodies directed to a p16 protein.
    Type: Application
    Filed: August 20, 2008
    Publication date: July 2, 2009
    Inventors: David H. Beach, Douglas J. Demetrick, Manuel Serrano, Gregory J. Hannon
  • Patent number: 7550561
    Abstract: The present invention relates to the discovery in eukaryotic cells, particularly human cells, a novel polypeptide of 16 kDa (hereinafter “p16INK4” or “p16”) can function as an inhibitor of cell cycle progression, and therefore ultimately of cell growth, and that similar to the role of p21 and p53, the p16 protein may function coordinately with the cell cycle regulatory protein, retinoblastoma (Rb).
    Type: Grant
    Filed: April 14, 1994
    Date of Patent: June 23, 2009
    Assignee: Cold Spring Harbor Laboratory
    Inventors: David H. Beach, Douglas J. Demetrick, Manuel Serrano, Gregory J. Hannon
  • Patent number: 7425617
    Abstract: The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a family of cell-cycle regulatory proteins (“CCR-proteins”). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth. The present invention comprises antibodies directed to such CCR-proteins.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: September 16, 2008
    Assignee: Cold Spring Harbor Laboratory
    Inventors: David H. Beach, Douglas J. Demetrick, Manuel Serrano, Gregory J. Hannon
  • Publication number: 20050248840
    Abstract: A targeting unit is incorporated into the main body of a solar telescope. The targeting image is provided by an aperture facing the sun in the housing of the telescope through which sunlight is received and directed to a transmissive viewing screen placed in the housing on the same side of the telescope's eyepiece. All parts of the targeting system are fixed to the housing of the telescope and removed from accidental contact by personnel operating the telescope, thereby minimizing the chance for events that might cause misalignments. In addition, this configuration makes it possible to easily position both the viewing screen and the eyepiece on the same side of the telescope following any degree of folding of the objective beam.
    Type: Application
    Filed: May 5, 2005
    Publication date: November 10, 2005
    Applicant: Coronado Instruments, Inc.
    Inventors: Yakov Sidorin, David Lunt, Geraldine Hogan, Manuel Serrano
  • Publication number: 20050078906
    Abstract: A compressive force is applied to a conventional air-spaced etalon filter to fine tune the thickness of the spacers to a precise and uniform optical length. The etalon is coupled to a housing device capable of adjusting the thickness of each spacer, thereby tuning the etalon to the desired filter wavelength. The resulting assembly is permanently set to the desired parameters for direct use in optical applications.
    Type: Application
    Filed: March 5, 2004
    Publication date: April 14, 2005
    Inventors: Andrew Lunt, Manuel Serrano, Yakov Sidorin, David Lunt
  • Publication number: 20030100489
    Abstract: The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a novel family of cell-cycle regulatory proteins (“CCR-proteins”). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth. Thus, similar to the role of p21 to the p53 checkpoint, the subject CCR-proteins may function coordinately with the cell-cycle regulatory protein, retinoblastoma (RB). Furthermore, the CCR-protein family includes a protein having an apparent molecular weight of 13.5 kDa (hereinafter “p13.5”). The presumptive role of p13.5, like p16 and p15, is in the regulation of the cell-cycle.
    Type: Application
    Filed: September 4, 2001
    Publication date: May 29, 2003
    Inventors: David H. Beach, Douglas J. Demetrick, Manuel Serrano, Gregory J. Hannon
  • Publication number: 20030097072
    Abstract: A method of mounting a transducer to a driveshaft which eliminates the need for a transducer housing, the improved method directly attaches the transducer to a rigid distal tip of a driveshaft which is part of a rotatable imaging core of a catheter assembly. The method contemplates heat treating the distal tip of the driveshaft to make it rigid, machining the distal tip to be dimensioned to hold the transducer, and attaching the transducer to the distal tip by clamping, crimping, or an adhesive.
    Type: Application
    Filed: November 18, 2002
    Publication date: May 22, 2003
    Inventors: Manuel Serrano, James D. Koger
  • Patent number: 6566054
    Abstract: The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of mutant cyclin dependent kinase (CDK) proteins. These proteins fail to bind to CDK-inhibitory proteins and thus lead to aberrant cell growth. Herein, screening assays are described to identify CDK mutant proteins and the uses of these mutant proteins as tumor vaccines is described.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: May 20, 2003
    Assignee: Cold Spring Harbor Laboratory
    Inventors: David H. Beach, Manuel Serrano
  • Patent number: 6486131
    Abstract: The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a novel family of cell-cycle regulatory proteins (“CCR-proteins”). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth. Thus, similar to the role of p21 to the p53 checkpoint, the subject CCR-proteins may function coordinately with the cell-cycle regulatory protein, retinoblastoma (RB). Furthermore, the CCR-protein family includes a protein having an apparent molecular weight of 13.5 kDa (hereinafter “p13.5”). The presumptive role of p13.5, like p16 and p15, is in the regulation of the cell-cycle.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: November 26, 2002
    Assignee: Cold Spring Harbor Laboratory
    Inventors: David H. Beach, Douglas J. Demetrick, Manuel Serrano, Gregory J. Hannon
  • Publication number: 20020087081
    Abstract: A method of mounting a transducer to a driveshaft which eliminates the need for a transducer housing, the improved method directly attaches the transducer to a rigid distal tip of a drive-shaft which is part of a rotatable imaging core of a catheter assembly. The method contemplates heat treating the distal tip of the drive-shaft to make it rigid, machining the distal tip to be dimensioned to hold the transducer, and attaching the transducer to the distal tip by clamping, crimping, or an adhesive.
    Type: Application
    Filed: January 4, 2001
    Publication date: July 4, 2002
    Inventors: Manuel Serrano, James D. Koger
  • Publication number: 20020082392
    Abstract: The present invention reldates to the discovery in eukaryotic cells, particularly mammalian cells, of a novel family of cell-cycle regulatory proteins (“CCR-proteins”). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth. Thus, similar to the role of p21 to the p53 checkpoint, the subject CCR-proteins may function coordinately with the cell-cycle regulatory protein, retinoblastoma (RB). Furthermore, the CCR-protein family includes a protein having an apparent molecular weight of 13.5 kDa (hereinafter “p13.5”). The presumptive role of p13.5, like p16 and p15, is in the regulation of the cell-cycle.
    Type: Application
    Filed: January 30, 1998
    Publication date: June 27, 2002
    Inventors: DAVID H. BEACH, DOUGLAS J. DEMETRICK, MANUEL SERRANO, GREGORY J. HANNON