Patents by Inventor Manuela García López

Manuela García López has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200102339
    Abstract: The present invention relates to sulphated disaccharides of formula (I) for use in the treatment of neuropathic pain. The present invention also relates to a pharmaceutical composition comprising the compound of formula (I) and at least one pharmaceutically acceptable excipient for use in the treatment of neuropathic pain. The compounds of formula (I) were effective in several experimental models of neuropathic pain for which reason these compounds can be used effectively for the treatment of different types of neuropathic pain and the clinical manifestations thereof, for example, mechanical allodynia or cold allodynia.
    Type: Application
    Filed: March 6, 2018
    Publication date: April 2, 2020
    Inventors: Josep VÉRGES MILANO, Eulàlia MONTELL BONAVENTURA, Ramon RUHÍ ROURA, Carlos Raúl ALÁEZ VERSÓN, Antonio GARCÍA GARCÍA, Manuela GARCÍA LÓPEZ, Juan Fernando PADÍN NOGUEIRA, Marcos MAROTO PÉREZ, Javier EGEA MÁlQUEZ
  • Publication number: 20180105492
    Abstract: The invention relates to the methods for producing derivatives of 3-alkylamino-1H-indole acrylate (I) with transcription factor Nrf2-inducing activity, free radical scavenging activity and neuroprotective ability. The invention also relates to the use of the derivatives according to the invention for the treatment of diseases, the pathogenesis of which involves oxidative stress, or diseases involving the deregulation of the activity of phase II genes activated by the factor Nrf2, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, ictus or amyotrophic lateral sclerosis.
    Type: Application
    Filed: October 15, 2015
    Publication date: April 19, 2018
    Inventors: Rafael LEON MARTINEZ, Izaskun BUENDIA ABAITUA, Elisa NAVARRO GONZALEZ DE MESA, Patrycja MICHALSKA, Isabel GAMEIRO ROS, Alicia LOPEZ VIVO, Javier EGEA MAIQUEZ, Manuela GARCIA LOPEZ, Antonio GARCIA GARCIA
  • Patent number: 8785416
    Abstract: The present invention relates to the use of a series of sulphated disaccharides for the preparation of a medicament for the treatment or prevention of a neurodegenerative and/or neurovascular disease, of a traumatic brain injury or of a traumatic spinal cord injury. The present invention also relates to the use of said sulphated disaccharides for the preparation of a neuroprotective medicament or of an antioxidant medicament. The neurodegenerative and/or neurovascular diseases are preferably: Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: July 22, 2014
    Assignees: Bioiberica, S.A., Universidad Autonoma de Madrid
    Inventors: Josep Verges Milano, Antonio Garcia Garcia, Ramon Ruhi Roura, Eulalia Montell Bonaventura, Manuela Garcia Lopez, Carlos Raul Alaez Verson, Josep Escaich Ferrer, Javier Egea Maiquez, Pilar Negredo Madrigal, Silvia Lorrio Gonzalez
  • Publication number: 20120309707
    Abstract: The present invention relates to the use of a series of sulphated disaccharides for the preparation of a medicament for the treatment or prevention of a neurodegenerative and/or neurovascular disease, of a traumatic brain injury or of a traumatic spinal cord injury. The present invention also relates to the use of said sulphated disaccharides for the preparation of a neuroprotective medicament or of an antioxidant medicament. The neurodegenerative and/or neurovascular diseases are preferably: Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke.
    Type: Application
    Filed: December 22, 2010
    Publication date: December 6, 2012
    Applicants: UNIVERSIDAD AUTONOMA DE MADRID, BIOIBERICA, S.A.
    Inventors: Josep Verges Milano, Antonio Garcia Garcia, Ramon Ruhi Roura, Eulalia Montell Bonaventura, Manuela Garcia Lopez, Carlos Raul Alaez Verson, Josep Escaich Ferrer, Javier Egea Maiquez, Pilar Negredo Madrigal, Silvia Lorrio Gonzalez
  • Publication number: 20100305157
    Abstract: Products of a general formula (I) and their use in the manufacture of medicines useful for the treatment of neurodegenerative diseases such as Alzheimer's disease or, in general, any disease or pathology produced by alterations of biological functions that can be treated or therapeutically modified by these products.
    Type: Application
    Filed: November 27, 2008
    Publication date: December 2, 2010
    Applicants: UNIVERSIDAD AUTONOMA DE MADRID, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    Inventors: Santiago Conde Ruzafa, Maria Isabel Rodriguez Franco, Mariana Paula Arce Garcia, Gema Cristina Gonzalez Muñoz, Mercedes Villarroya Sánchez, Manuela García López, Antonio Garcia Garcia