Patents by Inventor Manuela K. Hospenthal

Manuela K. Hospenthal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ubiquitin chain analysis
    Patent number: 9587265
    Abstract: There is described a method for analyzing ubiquitin polymers using linkage-specific deubiquitinase enzymes. Novel specificities of deubiquitinase enzymes are also provided.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: March 7, 2017
    Assignee: Medical Research Council
    Inventors: Tycho E. T. Mevissen, Manuela K. Hospenthal, David Komander
  • UBIQUITIN CHAIN ANALYSIS
    Publication number: 20140220591
    Abstract: There is described a method for analyzing ubiquitin polymers using linkage-specific deubiquitinase enzymes. Novel specificities of deubiquitinase enzymes are also provided.
    Type: Application
    Filed: September 24, 2012
    Publication date: August 7, 2014
    Applicant: Medical Research Council
    Inventors: Tycho E.T. Mevissen, Manuela K. Hospenthal, David Komander
  • UBIQUITIN CHAIN ASSEMBLY
    Publication number: 20140220625
    Abstract: There is provided a method for producing free polyubiquitin chains linked through a single desired lysine residue, comprising the steps of: (a) selecting an E3 ubiquitin ligase enzyme which is homologous to mammalian HECT E3 ligases and possesses the desired lysine residue specificity; (b) incubating the E3 enzyme with an E1 ubiquitin activating enzyme, an E2 ubiquitin conjugating enzyme and monomeric ubiquitin; and (c) if undesired linkages are present, removing the undesired linkages by exposure to a DUB enzyme having the appropriate specificity.
    Type: Application
    Filed: September 24, 2012
    Publication date: August 7, 2014
    Applicant: Medical Research Council
    Inventors: Manuela K. Hospenthal, David Komander