Patents by Inventor Manzo Shiono

Manzo Shiono has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5015746
    Abstract: 11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the formula ##STR1## an antiinflammatory composition thereof and a method for the production thereof.11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the present invention exhibits remarkably excellent antiinflammatory action and besides, displays reduced side effects and can be produced in high selectivity and good yield and conveniently.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: May 14, 1991
    Assignee: Kuraray Co., Ltd.
    Inventors: Yutaka Mizushima, Keiko Hoshi, Rie Igarashi, Hirofusa Ajioka, Noriyuki Yamamoto, Masahito Komuro, Koichi Kanehira, Masayuki Inoue, Takashi Nishida, Manzo Shiono, Michio Terasawa, Kenzo Arizono
  • Patent number: 4959393
    Abstract: A skin depigmental agent characterized by comprising a resorcinol derivative having a linear alkyl group is provided.
    Type: Grant
    Filed: April 27, 1989
    Date of Patent: September 25, 1990
    Assignee: Kuraray Company, Ltd.
    Inventors: Masahiro Torihara, Yoshin Tamai, Manzo Shiono, Kenji Tasaka
  • Patent number: 4946857
    Abstract: Novel terpene amino alcohols having an antiallergic activity or an activity of improving cerebral function are provided. Also provided are medicinal uses of the alcohols.
    Type: Grant
    Filed: July 21, 1986
    Date of Patent: August 7, 1990
    Assignee: Kuraray Co., Ltd.
    Inventors: Koichi Kanehira, Katsushi Eziri, Manzo Shiono, Yoshiji Fujita, Johji Yamahara
  • Patent number: 4728650
    Abstract: There are provided novel 3,4-dihydrobenzopyran derivatives having anti-peptic ulcer, antitussive and/or expectorant activity. Also provided are medicinal uses of said 3,4-dihydrobenzopyran derivatives.
    Type: Grant
    Filed: May 13, 1986
    Date of Patent: March 1, 1988
    Assignee: Kuraray Co., Ltd.
    Inventors: Katsushi Eziri, Koichi Kanehira, Manzo Shiono, Yoshiji Fujita, Johji Yamahara
  • Patent number: 4694090
    Abstract: Novel chroman compounds which have excellent antioxidant activity and/or analgesic activity or serve as precursors for such active compounds are provided. There are also provided uses of these active compounds as an antioxidant and/or analgesic.
    Type: Grant
    Filed: December 7, 1984
    Date of Patent: September 15, 1987
    Assignee: Kuraray Co., Ltd.
    Inventors: Manzo Shiono, Yoshiji Fujita, Takashi Nishida
  • Patent number: 4681890
    Abstract: Novel 3,4-dihydrobenzopyran compounds of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each hydrogen or nicotinoyl group and at least one of them is nicotinoyl group, m is an integer of 0, 1 or 2, and n is an integer of 0 or 1, which is useful for prophylaxis and treatment of hyperlipemia and the compounds wherein R.sup.1 and R.sup.3 being nicotinoyl group and n is 0 being also effective for prophylaxis and treatment of hepatic diseases, and pharmaceutical composition containing said compounds as an active ingredient.
    Type: Grant
    Filed: October 23, 1985
    Date of Patent: July 21, 1987
    Assignee: Kuraray Co., Ltd.
    Inventors: Koichi Kanehira, Manzo Shiono, Yoshiji Fujita, Takashi Nishida, Johji Yamahara
  • Patent number: 4656195
    Abstract: Novel ethylene oxide adducts are provided. They have properties suited for their use as base components of cosmetics and ointments. Thus, cosmetics and ointments containing those ethylene oxide adducts are also provided. There is further provided a method of producing such ethylene oxide adducts in high yields.
    Type: Grant
    Filed: October 8, 1985
    Date of Patent: April 7, 1987
    Assignee: Kuraray Co., Ltd.
    Inventors: Yoshin Tamai, Fumito Yamamoto, Manzo Shiono, Koichi Kanehira, Hiroshi Ozasa, Kaoru Nomoto
  • Patent number: 4523024
    Abstract: There is provided a class of novel 3,4-dihydro-2H-benzopyran derivatives which either have excellent inhibitory activity against unfavorable effects of heat, light and oxidative factors or are of use as precursors of compounds having such activity, and methods for producing these derivatives. Also provided are methods of using such 3,4-dihydro-2H-benzopyran derivatives as stabilizers for organic materials sensitive to heat, light or/and oxidative factors, and organic compositions containing such stabilizers.
    Type: Grant
    Filed: November 15, 1983
    Date of Patent: June 11, 1985
    Assignee: Kuraray Co., Ltd.
    Inventors: Manzo Shiono, Yoshiji Fujita, Takashi Nishida
  • Patent number: 4436939
    Abstract: A process for producing 1-(p-prenylphenyl)ethanol, which comprises reacting p-chloroprenylbenzene with magnesium at a temperature between 100.degree. C. and 150.degree. C. to form a Grignard reagent, and then reacting it with acetaldehyde.
    Type: Grant
    Filed: August 25, 1982
    Date of Patent: March 13, 1984
    Assignees: Taisho Pharmaceutical Co., Ltd., Kuraray Co., Ltd.
    Inventors: Takehiro Amano, Kensei Yoshikawa, Tatsuhiko Sano, Yutaka Ohuchi, Michihiro Ishiguro, Manzo Shiono, Yoshiji Fujita, Takashi Nishida
  • Patent number: 4433160
    Abstract: A process for producing an .alpha.-arylalkanoic acid ester represented by the general formula ##STR1## wherein Ar represents an aryl group which may optionally be substituted, and R.sup.1 and R.sup.2, independently from each other, represent a lower alkyl group,which comprises reacting a Grignard reagent prepared from an aryl halide of the general formulaAr--X.sup.1 (II)wherein Ar is as defined above and X.sup.1 represents a halogen atom,and magnesium, with an .alpha.-haloalkanoic acid ester of the general formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and X.sup.2 represents a halogen atom,said reaction of the Grignard reagent with the .alpha.-haloalkanoic acid ester of general formula (III) being carried out in the presence of a nickel compound.
    Type: Grant
    Filed: August 25, 1982
    Date of Patent: February 21, 1984
    Assignee: Taisho Pharmaceutical Company, Ltd.
    Inventors: Takehiro Amano, Kensei Yoshikawa, Tatsuhiko Sano, Yutaka Ohuchi, Michihiro Ishiguro, Manzo Shiono, Yoshiji Fujita, Takashi Nishida
  • Patent number: 4389412
    Abstract: A new pyrethroid compound which is low in toxicity to fish and a pesticidal composition containing the same as an active ingredient are provided. The above pyrethroid compound is a substituted cyclopropanecarboxylic acid ester of the general formula: ##STR1## (wherein A is a hydrogen atom or an ethynyl group) Despite its broad pesticidal spectrum and high pesticidal activity, this ester is very low in toxicity to man and domestic animals and especially low in toxicity to fish as compared with the conventional pyrethroid compounds.
    Type: Grant
    Filed: March 27, 1980
    Date of Patent: June 21, 1983
    Assignee: Kuraray Company, Ltd.
    Inventors: Fumio Mori, Manzo Shiono, Yoshiaki Omura
  • Patent number: 4252726
    Abstract: dl-.alpha.-Tocopherol is prepared by condensing trimethylhydroquinone with phytyl halide in a chlorinated lower aliphatic hydrocarbon solvent, in the presence of metallic tin and a Friedel-Crafts catalyst.
    Type: Grant
    Filed: January 12, 1979
    Date of Patent: February 24, 1981
    Assignee: Kuraray Co., Ltd.
    Inventors: Manzo Shiono, Yoichi Ninagawa, Yoshiaki Omura