Abstract: A misfire detection device for an engine having cylinders includes: a crank angle detector that detects an angular position of a crankshaft; a rotational speed calculator that calculates a rotational speed of the crankshaft on the basis of an output from the crank angle detector; and a misfire detector that obtains a difference between a rotational speed of the crankshaft in a combustion process in a diagnosis target cylinder and a rotational speed of the crankshaft in a combustion process in a last cylinder whose ignition order is immediately before the diagnosis target cylinder, and carries out a misfire detection by using a diagnostic value set on the basis of the difference.