Abstract: The present disclosure relates to compounds of Formula I, II, or III and compositions of the same, which are reversible off-on or ratiometric fluorescent iron sensors and are useful in live-cell imaging of labile iron ions and their quantification in subcellular compartments, as well as treatment of diseases associated with iron dyshomoestasis.

Abstract: This invention is in the field of fluorescence imaging and relates to a new near infrared (NIR) reactive oxygen species (ROS) sensor designed with controlled fluorescence on-off switching mechanism.

Abstract: The present disclosure relates to compounds of Formula I, II, or III and compositions of the same, which are reversible off-on or ratiometric fluorescent iron sensors and are useful in live-cell imaging of labile iron ions and their quantification in subcellular compartments, as well as treatment of diseases associated with iron dyshomoestasis.

Abstract: This invention is in the field of fluorescence imaging and relates to a new near infrared (NIR) reactive oxygen species (ROS) sensor designed with controlled fluorescence on-off switching mechanism.

Abstract: This invention is in the field of fluorescence imaging and relates to a new near infrared (NIR) reactive oxygen species (ROS) sensor designed with controlled fluorescence on-off switching mechanism.

Abstract: The disclosure provides new anti-cancer compositions that include a Her2 peptide that targets the Her2 receptor and comprises amino acid sequence GSGKCCYSL (SEQ ID NO:1); and a covalently-linked cytotoxic agent including artemisinin (Art) or a derivative thereof linked to the peptide. Biological assays have demonstrated that the Art-Her2 peptide conjugates described herein show excellent selective cytotoxic activity towards Her2-positive cancers, such as colon cancer, compared to normal colon cells.

Abstract: The present disclosure relates to compositions and methods for providing full spectrum photo protection to skin, which includes protection from infrared (IR) radiation and/or visible light in addition to protection from UV radiation. The compositions typically include: (a) baicalin; (b) one or more antioxidants selected from the group consisting of VENUCEANE (Thermus thermophiles ferment), polydatin, hesperetin, mango leaf extract, vitamin C; (c) optionally, one or more solubilizers; and (d) a cosmetically acceptable carrier. The compositions are unique in that the combination of (a), (b), optional (c), and (d) alone, provide at least full spectrum protection from ultraviolet radiation (UV), visible light, and infrared radiation (IR). The composition can additionally, optionally, include one or more UV filters to further enhance protection from UV radiation.

Abstract: This invention is in the field of fluorescence imaging and relates to a new near infrared (NIR) reactive oxygen species (ROS) sensor designed with controlled fluorescence on-off switching mechanism.

Abstract: The present disclosure relates to compositions and methods for providing full spectrum photo protection to skin, which includes protection from infrared (IR) radiation and/or visible light in addition to protection from UV radiation. The compositions typically include: (a) silymarin; (b) one or more antioxidants selected from the group consisting of ferulic acid, Vitamin C, polydatin, and hesperetin; (c) optionally, one or more solubilizers; and (d) a cosmetically acceptable carrier. The compositions are unique in that the combination of (a), (b), optional (c), and (d) alone, provide at least full spectrum protection from ultraviolet radiation (UV), visible light, and infrared radiation (IR). The composition can additionally, optionally, include one or more UV filters to further enhance protection from UV radiation.

Abstract: The present disclosure relates to methods and compositions for providing at least broad spectrum photo protection to skin, which includes protection from at least infrared (IR) radiation and/or visible light. The methods typically entail applying to skin a cosmetic composition comprising: (a) one or more antioxidants selected from the group consisting of baicalin, Venuceane™, ferulic acid, polydatin, silymarin, punica granatum extract, mango leaf extract, soliprin, catechin, hesperetin, astilbin, and DHC V; (b) optionally, one or more solubilizers; and (c) a cosmetically acceptable carrier; wherein the combination of (a), optional (b), and (c) alone, provide at least broad spectrum protection from both infrared (IR) radiation and visible light. UV filters can also optionally be included to provide additional protection from UV light.

Abstract: The present disclosure relates to compositions and methods for providing full spectrum photo protection to skin, which includes protection from infrared (IR) radiation and/or visible light in addition to protection from UV radiation. The compositions typically include: (a) silymarin; (b) one or more antioxidants selected from the group consisting of ferulic acid, Vitamin C, polydatin, and hespertin; (c) optionally, one or more solubilizers; and (d) a cosmetically acceptable carrier. The compositions are unique in that the combination of (a), (b), optional (c), and (d) alone, provide at least full spectrum protection from ultraviolet radiation (UV), visible light, and infrared radiation (IR). The composition can additionally, optionally, include one or more UV filters to further enhance protection from UV radiation.

Abstract: The present disclosure relates to compositions and methods for providing full spectrum photo protection to skin, which includes protection from infrared (IR) radiation and/or visible light in addition to protection from UV radiation. The compositions typically include: (a) baicalin; (b) one or more antioxidants selected from the group consisting of venuceane, polydatin, hesperetin, mango leaf extract, vitamin C; (c) optionally, one or more solubilizers; and (d) a cosmetically acceptable carrier. The compositions are unique in that the combination of (a), (b), optional (c), and (d) alone, provide at least full spectrum protection from ultraviolet radiation (UV), visible light, and infrared radiation (IR). The composition can additionally, optionally, include one or more UV filters to further enhance protection from UV radiation.

Abstract: The present disclosure relates to methods and compositions for providing at least broad spectrum photo protection to skin, which includes protection from at least infrared (IR) radiation and/or visible light. The methods typically entail applying to skin a cosmetic composition comprising: (a) one or more antioxidants selected from the group consisting of baicalin, Venuceane™, ferulic acid, polydatin, silymarin, punica granatum extract, mango leaf extract, soliprin, catechin, hesperetin, astilbin, and DHC V; (b) optionally, one or more solubilizers; and (c) a cosmetically acceptable carrier; wherein the combination of (a), optional (b), and (c) alone, provide at least broad spectrum protection from both infrared (IR) radiation and visible light. UV filters can also optionally be included to provide additional protection from UV light.