Patents by Inventor Maolin Yu

Maolin Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROARYL CARBOXAMIDE COMPOUNDS AS INHIBITORS OF RIPK2
    Publication number: 20190048000
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: October 12, 2018
    Publication date: February 14, 2019
    Inventors: Pingrong LIU, Craig Andrew MILLER, Maolin YU, Zhonghua ZHANG, Sabine RUPPEL, Anil K. PADAYANA
  • Substituted benzamides as RIPK2 inhibitors
    Patent number: 10138241
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: November 27, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Pingrong Liu, Craig Andrew Miller, Maolin Yu, Zhonghua Zhang, Sabine Ruppel, Anil K. Padyana
  • Aldosterone synthase inhibitors
    Patent number: 10131642
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2 and R3 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: November 20, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Michael Balestra, Jörg M. Bentzien, Jennifer Burke, Derek Cogan, Xin Guo, Keith R. Hornberger, John Lord, Kenneth M. Meyers, Zhaoming Xiong, Maolin Yu, Zhonghua Zhang
  • ALDOSTERONE SYNTHASE INHIBITORS
    Publication number: 20180312475
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2 and R3 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: January 28, 2016
    Publication date: November 1, 2018
    Inventors: Michael BALESTRA, Jörg M. BENTZIEN, Jennifer BURKE, Derek COGAN, Xin GUO, Keith R. HORNBERGER, John LORD, Kenneth M. MEYERS, Zhaoming XIONG, Maolin YU, Zhonghua ZHANG
  • HETEROARYL CARBOXAMIDE COMPOUNDS AS INHIBITORS OF RIPK2
    Publication number: 20180072717
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein.
    Type: Application
    Filed: September 6, 2017
    Publication date: March 15, 2018
    Inventors: Pingrong LIU, Craig Andrew MILLER, Maolin YU, Zhonghua ZHANG
  • Heterocyclic carboxylic acids as activators of soluble guanylate cyclase
    Patent number: 9353090
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R5, R6, R7, R8, R9, B, V, W, X, Y, Z and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: May 31, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Jehrod Burnett Brenneman, John David Ginn, Tamara Denise Hopkins, Michael D. Lowe, Christopher Ronald Sarko, John A. Westbrook, Maolin Yu, Zhonghua Zhang
  • Aldosterone synthase inhibitors
    Patent number: 9334285
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein Cy, R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: May 10, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Jennifer Burke, Matthew A. Cerny, Derek Cogan, Kosea S. Frederick, John Lord, Daniel Richard Marshall, Bryan P. McKibben, Simon Suprenant, Maolin Yu, Yunlong Zhang, Lee Fader
  • ALDOSTERONE SYNTHASE INHIBITORS
    Publication number: 20160024105
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein Cy, R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: July 23, 2015
    Publication date: January 28, 2016
    Inventors: Jennifer BURKE, Matthew A. CERNY, Derek COGAN, Kosea S. FREDERICK, John LORD, Daniel Richard MARSHALL, Bryan P. MCKIBBEN, Simon SURPRENANT, Maolin YU, Yunlong ZHANG, Lee FADER
  • HETEROCYCLIC CARBOXYLIC ACIDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE
    Publication number: 20160024059
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R5, R6, R7, R8, R9, B, V, W, X, Y, Z and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: July 21, 2015
    Publication date: January 28, 2016
    Inventors: Jehrod Burnett BRENNEMAN, John David GINN, Tamara Denise HOPKINS, MIchael D. LOWE, Christopher Ronald SARKO, John A. WESTBROOK, Maolin YU, Zhonghua ZHANG
  • Soluble guanylate cyclase activators
    Patent number: 8815857
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: August 26, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Todd Bosanac, Angela Berry, John David Ginn, Tamara Denise Hopkins, Sabine Schlyer, Fariba Soleymanzadeh, John Westbrook, Maolin Yu, Zhonghua Zhang
  • SOLUBLE GUANYLATE CYCLASE ACTIVATORS
    Publication number: 20130203729
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: August 9, 2012
    Publication date: August 8, 2013
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Todd BOSANAC, Angela BERRY, John David GINN, Tamara Denise HOPKINS, Sabine SCHLYER, Fariba SOLEYMANZADEH, John WESTBROOK, Maolin YU, Zhonghua ZHANG
  • Method and apparatus for inspecting an object after stamping
    Publication number: 20060222237
    Abstract: A method and apparatus for inspecting an object after stamping is described. The method and apparatus comprises determining a temperature distribution of an object after stamping; obtaining one or more thermal images of the object after stamping; and comparing the determined temperature distribution with the obtained thermal images so as to identify defects existing in the object after stamping, in which the difference between the temperature distribution and the thermal images indicates the presence of defects in the object. The method and apparatus can therefore inspect and analysis problems of the object occurred during the stamping process.
    Type: Application
    Filed: February 2, 2006
    Publication date: October 5, 2006
    Applicants: The Chinese University of Hong Kong, Mansfield Manufacturing Co., Ltd.
    Inventors: Ruxu Du, Maolin Yu, Yiu-Ming Ng, Wai To