Abstract: The present invention relates to a compound used as an SHP2 inhibitor and the use thereof. Specifically, the compound of the present invention has a structure as represented by formula I?, wherein the definitions of each group and each substituent are as described in the description. The compound has a high inhibitory effect on the activity of the SHP2 phosphatase, and can be used for preventing or treating SHP2-related diseases.

Abstract: The present invention relates to the technical field of medicines. Specifically disclosed is a compound as represented by formula I?, or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, symbols therein being as defined in the claims. The compound of the present invention may be used as a drug for regulating RET kinase activity or treating RET-related diseases, and has good pharmacokinetic properties.

Abstract: The present invention relates to a compound used as an RET kinase inhibitor and an application thereof. The compound has a structure represented by formula F, has a good inhibitory ability for RET kinase, and has relatively good pharmacodynamic and pharmacokinetic performance, and lower toxic side effects.

Abstract: The present invention relates to a compound used as an EGFR kinase inhibitor and the use thereof. The compound has a structure as shown in formula I, and can be used to adjust the kinase activity or treat related diseases, especially non-small cell lung cancer.

Abstract: The present invention belongs to the field of medical technology and specifically disclosed is a compound represented by formula (I?), or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and each symbol therein is as defined in the claims. The compound of the present invention may be used as a drug for regulating RET kinase activity or treating RET-related diseases, and has better pharmacokinetic properties.

Abstract: An iterative approach to solving the optimization problem is provided. The invention provides an iteration of four basic operations; determining the segments, balancing the segments, expanding a segment, and solving the segment optimization. The method and apparatus can use any off-the-shelf linear programming (LP) solver, such as Dash Optimization Xpress, by Dash Optimization, during the solve operation. The size of the problem fed into the LP solver remains bounded and relatively small compared to the entire problem size. Thus, the algorithm can solve problems of several orders of magnitude larger. In one embodiment of the invention, the sampling and segmentation techniques are removed to where the problem is solved at the account-level. In the above cases, the solution is produced in a more cost-effective manner and the best possible return is achieved because the doubt of achieving a true global solution is removed.

Abstract: An iterative approach to solving the optimization problem is provided. The invention provides an iteration of four basic operations; determining the segments, balancing the segments, expanding a segment, and solving the segment optimization. The method and apparatus can use any off-the-shelf linear programming (LP) solver, such as Dash Optimization Xpress, by Dash Optimization, during the solve operation. The size of the problem fed into the LP solver remains bounded and relatively small compared to the entire problem size. Thus, the algorithm can solve problems of several orders of magnitude larger. In one embodiment of the invention, the sampling and segmentation techniques are removed to where the problem is solved at the account-level. In the above cases, the solution is produced in a more cost-effective manner and the best possible return is achieved because the doubt of achieving a true global solution is removed.