Abstract: The present invention discloses a hierarchical routing method oriented to a cross-boundary service network. The hierarchical routing method includes the following steps: (1): proposing reference services for services with same or similar functions in a service network, with differences in format and usage mode, and establishing a unified and standardized usage view for a user; and (2): establishing a method for mapping between the reference services and ordinary services to map the multiple ordinary services with similar functions into the unified reference services, and automatically selecting an optimal ordinary service when called by the user. The hierarchical routing method provided by the present invention can implement high-speed routing of service call in the service network, thereby providing a basis for aggregation and interoperation of cross-boundary services.

Abstract: The present invention relates to the technical field of medicines. Specifically disclosed is a compound as represented by formula I?, or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, symbols therein being as defined in the claims. The compound of the present invention may be used as a drug for regulating RET kinase activity or treating RET-related diseases, and has good pharmacokinetic properties.

Abstract: The present invention relates to a compound used as an RET kinase inhibitor and an application thereof. The compound has a structure represented by formula F, has a good inhibitory ability for RET kinase, and has relatively good pharmacodynamic and pharmacokinetic performance, and lower toxic side effects.

Abstract: The present invention relates to a compound used as an EGFR kinase inhibitor and the use thereof. The compound has a structure as shown in formula I, and can be used to adjust the kinase activity or treat related diseases, especially non-small cell lung cancer.

Abstract: The present invention belongs to the field of medical technology and specifically disclosed is a compound represented by formula (I?), or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and each symbol therein is as defined in the claims. The compound of the present invention may be used as a drug for regulating RET kinase activity or treating RET-related diseases, and has better pharmacokinetic properties.

Abstract: An iterative approach to solving the optimization problem is provided. The invention provides an iteration of four basic operations; determining the segments, balancing the segments, expanding a segment, and solving the segment optimization. The method and apparatus can use any off-the-shelf linear programming (LP) solver, such as Dash Optimization Xpress, by Dash Optimization, during the solve operation. The size of the problem fed into the LP solver remains bounded and relatively small compared to the entire problem size. Thus, the algorithm can solve problems of several orders of magnitude larger. In one embodiment of the invention, the sampling and segmentation techniques are removed to where the problem is solved at the account-level. In the above cases, the solution is produced in a more cost-effective manner and the best possible return is achieved because the doubt of achieving a true global solution is removed.

Abstract: An iterative approach to solving the optimization problem is provided. The invention provides an iteration of four basic operations; determining the segments, balancing the segments, expanding a segment, and solving the segment optimization. The method and apparatus can use any off-the-shelf linear programming (LP) solver, such as Dash Optimization Xpress, by Dash Optimization, during the solve operation. The size of the problem fed into the LP solver remains bounded and relatively small compared to the entire problem size. Thus, the algorithm can solve problems of several orders of magnitude larger. In one embodiment of the invention, the sampling and segmentation techniques are removed to where the problem is solved at the account-level. In the above cases, the solution is produced in a more cost-effective manner and the best possible return is achieved because the doubt of achieving a true global solution is removed.