Patents by Inventor Maoyi LEI

Maoyi LEI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic compound that acts as CRBN protein regulator
    Patent number: 11905276
    Abstract: A compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and disclosed is an application thereof in the preparation of a medication for treating diseases related to a CRBN receptor.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: February 20, 2024
    Assignee: MEDSHINE DISCOVERY INC.
    Inventors: Yunfu Luo, Maoyi Lei, Yu Xu, Junmiao Li, Guoli Zhang, Jinghong Dong, Shuhui Chen
  • BICYCLIC COMPOUND THAT ACTS AS CRBN PROTEIN REGULATOR
    Publication number: 20230348441
    Abstract: A compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and disclosed is an application thereof in the preparation of a medication for treating diseases related to a CRBN receptor.
    Type: Application
    Filed: September 14, 2020
    Publication date: November 2, 2023
    Inventors: Yunfu LUO, Maoyi LEI, Yu XU, Junmiao LI, Guoli ZHANG, Jinghong DONG, Shuhui CHEN
  • PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME
    Publication number: 20230158152
    Abstract: A proteolysis targeting chimera (PROTAC), and an application thereof in preparation of a drug for treating a related disease. Specifically disclosed are a compound as represented by formula (I) and a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 17, 2021
    Publication date: May 25, 2023
    Inventors: Maoyi LEI, Lei PENG, Yunfu LUO, Yu XU, Junmiao LI, Xinyuan DENG, Zisheng KANG, Weizhi GE, GuoIi ZHANG, Shuhui CHEN
  • CRYSTAL OF TRICYCLIC COMPOUND ACTING ON CRBN PROTEIN AND PREPARATION METHOD THEREFOR
    Publication number: 20230123104
    Abstract: Disclosed are a crystal of a tricyclic compound acting on CRBN protein and a preparation method therefor, specifically relating to a crystal of a compound of formula (I) and a preparation method therefor. An application of the crystal in the preparation of drugs for treating CRBN protein-related diseases is further comprised.
    Type: Application
    Filed: March 5, 2021
    Publication date: April 20, 2023
    Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Maoyi LEI, Yu XU, Yunfu LUO, Zhenliang SHAN
  • Medical application of pyrimidine sulfonamides derivatives
    Patent number: 11628168
    Abstract: The present disclosure provides application of a compound in conformity with a general formula I and an isomer or pharmaceutically acceptable salt thereof to preparation of a medicinal composition for treating or preventing a high altitude disease. The high altitude disease is selected from an acute high altitude disease and a chronic high altitude disease generated in a high altitude environment with an altitude of 2,000 m or above.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: April 18, 2023
    Assignees: CHINESE PLA GENERAL HOSPITAL, SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT COMPANY, LTD.
    Inventors: Kunlun He, Xiaojian Gao, Chunlei Liu, Zeyu Zhang, Xin Li, Chen Li, Yunfu Luo, Maoyi Lei, Junmiao Li, Yiwei Wang
  • CRYSTAL FORM OF BENZIMIDAZOLE-2-ONE COMPOUND, SOLVATE THEREOF, CRYSTAL FORM OF SOLVATE THEREOF, AND PREPARATION METHOD THEREOF
    Publication number: 20220372001
    Abstract: A crystal form of compound 1, a solvate thereof, a crystal form of the solvate thereof, and a preparation method therefor. Further comprised is an application of the crystal forms in the preparation of a medicament for treating diseases related to TNF?.
    Type: Application
    Filed: July 3, 2020
    Publication date: November 24, 2022
    Applicant: MEDSHINE DISCOVERY INC.
    Inventors: Maoyi LEI, Yunfu LUO
  • FUSED CYCLIC COMPOUND CAPABLE OF DEGRADING PROTEIN AND USE THEREOF
    Publication number: 20220324848
    Abstract: The present disclosure discloses a compound shown in formula (II) and a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising the compound as an active ingredient, and use thereof in the preparation of medicaments for protein degradation.
    Type: Application
    Filed: September 11, 2020
    Publication date: October 13, 2022
    Inventors: Yunfu LUO, Yong CANG, Bo PENG, Maoyi LEI, Yu XU, Shuhui CHEN
  • CRYSTAL FORM OF PYRIMIDINE SULFONAMIDE COMPOUND AND PREPARATION METHOD THEREFOR
    Publication number: 20220220098
    Abstract: Disclosed are a Crystal Form (I) of a pyrimidine sulfonamide compound and a preparation method therefor. The present disclosure relates to an application thereof in the preparation of a medicament for treating diseases related to ETA receptor antagonists.
    Type: Application
    Filed: May 22, 2020
    Publication date: July 14, 2022
    Inventors: Junmiao LI, Maoyi LEI, Yunfu LUO
  • Crystal form of 1H-imidazo[4,5-b]pyridine-2(3H)-one compound and preparation process therefor
    Patent number: 11325907
    Abstract: Disclosed are a crystal form of 1H-imidazo[4,5-b]pyridine-2(3H)-one compound and a preparation process therefor, and use of the crystal form in the manufacture of a medicament for treating a disease associated with PDE4 receptor.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: May 10, 2022
    Assignee: Medshine Discovery Inc.
    Inventors: Maoyi Lei, Yu Xu, Yunfu Luo
  • Pyrimidine sulfamide derivative and preparation method and medical application thereof
    Patent number: 11319305
    Abstract: Disclosed are a series of pyrimidine sulfamide compounds and applications thereof in preparing a drug for a disease related to an ETA receptor antagonist. In particular, disclosed is a derived compound represented by formula (I) or a tautomer or pharmaceutically acceptable composition thereof.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: May 3, 2022
    Assignee: Shijiazhuang Sagacity New Drug Development Co., Ltd.
    Inventors: Yunfu Luo, Maoyi Lei, Junmiao Li, Yu Xu, Ran Wei, Shuhui Chen
  • Tricyclic furan-substituted piperidinedione compound
    Patent number: 11319330
    Abstract: Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: May 3, 2022
    Assignee: MEDSHINE DISCOVERY INC.
    Inventors: Maoyi Lei, Yunfu Luo, Yu Xu, Guoli Zhang, Jinghong Dong, Jian Li, Shuhui Chen
  • TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS
    Publication number: 20220119376
    Abstract: The present invention discloses a series of tricyclic compounds and use thereof in preparing a medicament for treating a disease related to CRBN protein. Specifically, the present invention discloses a derivative compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 9, 2019
    Publication date: April 21, 2022
    Inventors: Maoyi Lei, Yunfu Luo, Yu Xu, Guoli Zhang, Zhijuan Yu, Jian Li, Shuhui Chen
  • MEDICAL APPLICATION OF PYRIMIDINE SULFONAMIDES DERIVATIVES
    Publication number: 20210393627
    Abstract: The present disclosure provides application of a compound in conformity with a general formula I and an isomer or pharmaceutically acceptable salt thereof to preparation of a medicinal composition for treating or preventing a high altitude disease. The high altitude disease is selected from an acute high altitude disease and a chronic high altitude disease generated in a high altitude environment with an altitude of 2,000 m or above.
    Type: Application
    Filed: June 5, 2019
    Publication date: December 23, 2021
    Applicants: CHINESE PLA GENERAL HOSPITAL, SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT COMPANY, LTD.
    Inventors: Kunlun HE, Xiaojian GAO, Chunlei LIU, Zeyu ZHANG, Xin LI, Chen LI, Yunfu LUO, Maoyi LEI, Junmiao LI, Yiwei WANG
  • TRICYCLIC FURAN-SUBSTITUTED PIPERIDINEDIONE COMPOUND
    Publication number: 20210317138
    Abstract: Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 9, 2019
    Publication date: October 14, 2021
    Inventors: Maoyi LEI, Yunfu LUO, Yu XU, Guoli ZHANG, Jinghong DONG, Jian LI, Shuhui CHEN
  • TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND
    Publication number: 20210317109
    Abstract: Disclosed is a series of tricyclic substituted piperidine dione compounds, and applications thereof in the preparation of medicines for treating diseases related to CRBN protein; specifically disclosed are the derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 9, 2019
    Publication date: October 14, 2021
    Inventors: Yunfu LUO, Maoyi LEI, Yong WANG, Jian LI, Shuhui CHEN
  • CRYSTAL FORM OF 1H-IMIDAZO[4,5-B]PYRIDINE-2(3H)-ONE COMPOUND AND PREPARATION PROCESS THEREFOR
    Publication number: 20210198253
    Abstract: Disclosed are a crystal form of 1H-imidazo[4,5-b]pyridine-2(3H)-one compound and a preparation process therefor, and use of the crystal form in the manufacture of a medicament for treating a disease associated with PDE4 receptor.
    Type: Application
    Filed: January 29, 2019
    Publication date: July 1, 2021
    Inventors: Maoyi LEI, Yu XU, Yunfu LUO
  • PYRIMIDINE SULFAMIDE DERIVATIVE AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF
    Publication number: 20200283425
    Abstract: Disclosed are a series of pyrimidine sulfamide compounds and applications thereof in preparing a drug for a disease related to an ETA receptor antagonist. In particular, disclosed is a derived compound represented by formula (I) or a tautomer or pharmaceutically acceptable composition thereof.
    Type: Application
    Filed: November 19, 2018
    Publication date: September 10, 2020
    Inventors: Yunfu LUO, Maoyi LEI, Junmiao LI, Yu XU, Ran WEI, Shuhui CHEN
  • PDE4 inhibitor
    Patent number: 10662189
    Abstract: Provided are a PDE4 inhibitor and a use thereof in the preparation of a medicament for treating PDE4 related diseases. Specifically disclosed are the compound as shown in formula (I) and a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: May 26, 2020
    Assignee: SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.
    Inventors: Yunfu Luo, Chundao Yang, Maoyi Lei, Ling Liu, Guoping Hu, Jian Li, Shuhui Chen
  • Cyclic compound acting as PDE4 inhibitor
    Patent number: 10532986
    Abstract: Provided are a phosphodiesterase-4 (PDE4) inhibitor and application thereof in preparation of a medication for treating a disease related to PDE4. Specifically disclosed is a compound as shown in formula (I) and a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: January 14, 2020
    Assignee: Medshine Discovery Inc.
    Inventors: Yunfu Luo, Chundao Yang, Maoyi Lei, Lanbao Sun, Guoping Hu, Jian Li, Shuhui Chen
  • CYCLIC COMPOUND ACTING AS PDE4 INHIBITOR
    Publication number: 20190210975
    Abstract: Provided are a phosphodiesterase-4 (PDE4) inhibitor and application thereof in preparation of a medication for treating a disease related to PDE4. Specifically disclosed is a compound as shown in formula (I) and a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 22, 2017
    Publication date: July 11, 2019
    Inventors: Yunfu LUO, Chundao YANG, Maoyi LEI, Lanbao SUN, Guoping HU, Jian LI, Shuhui CHEN