Patents by Inventor María Esther ONECHA DE LA FUENTE

María Esther ONECHA DE LA FUENTE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining the presence or absence of minimal residual disease (MRD) in a subject who has been treated for a disease
    Patent number: 11781189
    Abstract: The present invention is focused on a method, kit and system for determining the presence or absence of minimal residual disease in a subject who has been treated for a proliferative disease wherein said method, kit and system comprise: (A) amplifying and sequencing at least one nucleotide sequence comprised in genomic DNA from a biological sample obtained from said subject prior to treatment for said disease, to obtain a first list of characters reading from left to right; (B) amplifying and sequencing at least one nucleotide sequence comprised in genomic DNA from a biological sample obtained from said subject after treatment for said disease, to obtain a second list of characters reading from left to right, wherein when a nucleotide sequence is mutated it is a genetic marker for said proliferative disease; (C) determining, for each second list of characters obtained in step (B), the degree of similarity, DS, with each first list of characters obtained in step (A); (D) selecting, for each second list of c
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: October 10, 2023
    Inventors: Santiago Barrio García, Rosa María Ayala Díaz, María Inmaculada Rapado Martinez, Eva María Garrido Martín, Luis Paz-Ares Rodriguez, Maria Esther Onecha De La Fuente, Joaquín Martínez López
  • METHOD FOR DETERMINING THE PRESENCE OR ABSENCE OF MINIMAL RESIDUAL DISEASE (MRD) IN A SUBJECT WHO HAS BEEN TREATED FOR A DISEASE
    Publication number: 20220380852
    Abstract: The present invention is focused on a method, kit and system for determining the presence or absence of minimal residual disease in a subject who has been treated for a proliferative disease wherein said method, kit and system comprise: (A) amplifying and sequencing at least one nucleotide sequence comprised in genomic DNA from a biological sample obtained from said subject prior to treatment for said disease, to obtain a first list of characters reading from left to right; (B) amplifying and sequencing at least one nucleotide sequence comprised in genomic DNA from a biological sample obtained from said subject after treatment for said disease, to obtain a second list of characters reading from left to right, wherein when a nucleotide sequence is mutated it is a genetic marker for said proliferative disease; (C) determining, for each second list of characters obtained in step (B), the degree of similarity, DS, with each first list of characters obtained in step (A); (D) selecting, for each second list of c
    Type: Application
    Filed: August 27, 2020
    Publication date: December 1, 2022
    Inventors: Santiago BARRIO GARCÍA, Rosa María AYALA DÍAZ, María Inmaculada RAPADO MARTINEZ, Eva María GARRIDO MARTÍN, Luis PAZ-ARES RODRIGUEZ, María Esther ONECHA DE LA FUENTE, Joaquín MARTÍNEZ LÓPEZ