Abstract: A method for modifying a silicone surface to introduce amino groups thereon, which can be further reacted to introduce desired substituents and activities. The method comprises treating the silicone elastomer surface with a substance that is selected from a molecule that contains at least one primary or secondary amino group and at least one further nucleophilic group selected from OH, SH COOH, NH2, amide, and NHR where R is alkyl; or a silanization reagent with the formula Si—(OR1)(OR2)(OR3)R5NHR4 where groups R1,R2,R3 are independently selected from straight or branched alkyl or alkylene and preferably methyl or ethyl, R5 is a straight or branched alkyl or alkylene, and R4 is H or an organic group. Advantageously, the surface does not need to be pre-treated with oxidizing agent such as ozone, hydrogen peroxide or plasma treatment prior to the treating step of the invention.

Abstract: Disclosed is a method of preparing N-alkylated chitosan derivatives by treating chitosan with an acid and subsequently reacting the chitosan with an alkylating agent in the presence of a base. Also provided are novel N-alkylated chitosan derivatives.

Abstract: Disclosed is a method of preparing N-alkylated chitosan derivatives by treating chitosan with an acid and subsequently reacting the chitosan with an alkylating agent in the presence of a base. Also provided are novel N-alkylated chitosan derivatives.

Abstract: Disclosed is a method of preparing N-alkylated chitosan derivatives by treating chitosan with an acid and subsequently reacting the chitosan with an alkylating agent in the presence of a base. Also provided are novel N-alkylated chitosan derivatives.

Abstract: Disclosed is a method of preparing N-alkylated chitosan derivatives by treating chitosan with an acid and subsequently reacting the chitosan with an alkylating agent in the presence of a base. Also provided are novel N-alkylated chitosan derivatives.

Abstract: The present invention relates to novel chitosan-based conjugates, e.g. nanocarriers, comprising a derivative of the biocompatible polymer chitosan conjugated to a photosensitizing agent, and uses thereof in photochemical internalization (PCI) and photodynamic therapy (PDT). The invention also relates to the use of the novel conjugates of the invention in treatment or prevention of diseases, particularly cancer, and for vaccination purposes.

Abstract: The present invention relates to novel chitosan-based conjugates, e.g. nanocarriers, comprising a derivative of the biocompatible polymer chitosan conjugated to a photosensitising agent, and uses thereof in photochemical internalisation (PCI) and photodynamic therapy (PDT). The invention also relates to the use of the novel conjugates of the invention in treatment or prevention of diseases, particularly cancer, and for vaccination purposes.

Abstract: This invention relates to a new method to improve the complexation efficacy of a basic active substance and a cyclodextrin using an acidic volatile substance. The invention further relates to a method to prepare high-energy complexes of a basic active substance and a cyclodextrin that form super-saturated solutions when dissolved. Also, the present invention relates to a pharmaceutical formulation comprising said complex and the use of such a formulation in therapy.

Abstract: Methods for enhancing the complexation efficiency of a drug with cyclodextrin and for enhancing the availability of a drug following administration of a cyclodextrin-drug complex.

Abstract: Methods for enhancing the complexation efficiency of a drug with cyclodextrin and for enhancing the availability of a drug following administration of a cyclodextrin-drug complex.