Patents by Inventor Mara Rossi

Mara Rossi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180362609
    Abstract: The present invention provides a composition comprising an interferon-beta (IFN-beta) protein of which at least 80% is deamidated, a deamidated IFN-beta 1a protein, methods of producing deamidated proteins, and therapeutic uses of such compositions and deamidated IFN-beta 1a proteins.
    Type: Application
    Filed: August 30, 2018
    Publication date: December 20, 2018
    Inventors: WOLF PALINSKY, MARA ROSSI, ANNA R. PEZZOTTI
  • Publication number: 20170145068
    Abstract: The present invention provides a composition comprising an interferon-beta (IFN-beta) protein of which at least 80% is deamidated, a deamidated IFN-beta 1a protein, methods of producing deamidated proteins, and therapeutic uses of such compositions and deamidated IFN-beta 1a proteins.
    Type: Application
    Filed: April 1, 2015
    Publication date: May 25, 2017
    Inventors: WOLF PALINSKY, MARA ROSSI, ANNA R. PEZZOTTI
  • Patent number: 8993724
    Abstract: The present invention relates to a process for the production of interferon beta, and to an interferon beta composition having a unique glycosylation pattern.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: March 31, 2015
    Assignee: Ares Trading S.A.
    Inventors: Dina Fischer, Alain Bernard, Paul Ducommun, Mara Rossi
  • Patent number: 8604175
    Abstract: The invention relates to a method for purifying a glycoprotein, preferably FSH or a FSH mutant, comprising the steps of subjecting a liquid containing FSH or a FSH mutant to: (1) a dye affinity chromatography; (2) a weak anion exchange chromatography; (3) a hydrophobic interaction chromatography; and (4) a strong anion exchange chromatography; which may be carried out in any order.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: December 10, 2013
    Assignee: Ares Trading S.A.
    Inventors: Thierry Ziegler, Mara Rossi, Antonello Datola, Sabrina Fiumi
  • Publication number: 20110305669
    Abstract: The present invention relates to a process for the production of interferon beta, and to an interferon beta composition having a unique glycosylation pattern.
    Type: Application
    Filed: June 14, 2011
    Publication date: December 15, 2011
    Applicant: ARES TRADING S.A.
    Inventors: DINA FISCHER, Alain Bernard, Paul Ducommun, Mara Rossi
  • Patent number: 7866203
    Abstract: The invention relates to the analytical determination of poloxamers in a liquid protein sample.
    Type: Grant
    Filed: September 14, 2006
    Date of Patent: January 11, 2011
    Assignee: Ares Trading S.A.
    Inventor: Mara Rossi
  • Patent number: 7820800
    Abstract: The invention relates to a process for the purification of IL-18 binding protein (IL-18BP) from a fluid comprising hydrophobic charge-induction chromatography.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: October 26, 2010
    Assignee: Ares Trading S.A.
    Inventors: Mara Rossi, Thierry Ziegler, Laure Valognes
  • Patent number: 7754860
    Abstract: The invention provides a method for purifying recombinant FSH.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: July 13, 2010
    Assignee: Ares Trading S.A.
    Inventor: Mara Rossi
  • Publication number: 20090311732
    Abstract: This invention relates to analytical methods for quantification of truncation at the C-terminus of an Fc-containing protein.
    Type: Application
    Filed: December 20, 2007
    Publication date: December 17, 2009
    Applicant: Ares Trading S.A.
    Inventors: Mara Rossi, Irene Cecchini
  • Publication number: 20090209454
    Abstract: The invention relates to a method for purifying a glycoprotein, preferably FSH or a FSH mutant comprising the steps of subjecting a liquid containing said FSH or a FSH mutant to: (1) a dye affinity chromatography; (2) a weak anion exchange chromatography; (3) a hydrophobic interaction chromatography; and (4) a strong anion exchange chromatography; which may be carried out in any order.
    Type: Application
    Filed: December 6, 2006
    Publication date: August 20, 2009
    Applicant: ARES TRADING S.A.
    Inventors: Thierry Ziegler, Mara Rossi, Antonello Datola, Sabrina Fiumi
  • Publication number: 20080219952
    Abstract: The present invention relates to a process for the production of interferon beta, and to an interferon beta composition having a unique glycosylation pattern.
    Type: Application
    Filed: August 26, 2005
    Publication date: September 11, 2008
    Applicant: ARES TRADING S.A.
    Inventors: Dina Fischer, Alain Bernard, Paul Ducommun, Mara Rossi
  • Publication number: 20080190179
    Abstract: The invention relates to the analytical determination of poloxamers in a liquid protein sample.
    Type: Application
    Filed: September 14, 2006
    Publication date: August 14, 2008
    Applicant: ARES TRADING S.A.
    Inventor: Mara Rossi
  • Publication number: 20070299001
    Abstract: A process for the purification of recombinant human Chorionic Gonadotropin (hCG) from a sample of crude recombinant hCG in the supernatant of CHO cells comprises the combined use of ion-exchange chromatography and reverse phase HPLC. The ion-exchange chromatography is performed twice and the final use of a size exclusion chromatography allows the purification from any residual traces of contaminants. The specific bioactivity of the highly purified hCG obtained form the process is particularly high, amounting to about 25,000 IU/mg.
    Type: Application
    Filed: August 28, 2007
    Publication date: December 27, 2007
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Gianfranco PARADISI, Mara Rossi, Laura Scaglia
  • Patent number: 7297777
    Abstract: A process for the purification of recombinant human Chorionic Gonadotropin (hCG) from a sample of crude recombinant hCG in the supernatant of CHO cells comprises the combined use of ion-exchange chromatography and reverse phase HPLC. The ion-exchange chromatography is performed twice and the final use of a size exclusion chromatography allows the purification from any residual traces of contaminants. The specific bioactivity of the highly purified hCG obtained form the process is particularly high, amounting to about 25,000 IU/mg.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: November 20, 2007
    Assignee: Laboratoires Serono SA
    Inventors: Gianfranco Paradisi, Mara Rossi, Laura Scaglia
  • Publication number: 20070129295
    Abstract: The invention provides a method for purifying recombinant FSH.
    Type: Application
    Filed: December 16, 2004
    Publication date: June 7, 2007
    Applicant: Ares Trading S.A.
    Inventor: Mara Rossi
  • Publication number: 20070037734
    Abstract: The invention relates to a process for the purification of IL-18 binding protein (IL-18BP) from a fluid comprising hydrophobic charge-induction chromatography.
    Type: Application
    Filed: November 4, 2004
    Publication date: February 15, 2007
    Inventors: Mara Rossi, Thierry Ziegler, Laure Valognes
  • Publication number: 20060128616
    Abstract: A new purification process for Tumor Necrosis Factor-binding proteins is described. In particular this process is characterized by the use as capture step of an Immobilized Metal Affinity Chromatography (IMAC) using copper as metal. This brings advantages in terms of process yields, purity of the final product and applicability to industrial scale.
    Type: Application
    Filed: November 13, 2003
    Publication date: June 15, 2006
    Applicant: Ares Trading S.A.
    Inventor: Mara Rossi
  • Patent number: 7053054
    Abstract: A process for the purification of recombinant human Luteinizing Hormone (LH) from a sample of crude recombinant LH in the supernatant of CHO cells comprises the combined use of the ion-exchange chromatography and reverse phase HPLC. The ion-exchange chromatography and the reverse phase HPLC are performed twice and the final use of a gel permeation column allows the purification from any residual traces of contaminants. The specific bioactivity of the highly purified LH obtained from the process is particularly high, amounting to 25,000 IU/mg.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: May 30, 2006
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Gianfranco Paradisi, Mara Rossi, Laura Scaglia
  • Publication number: 20060079460
    Abstract: Recombinant human luteinizing hormone (LH) having a specific bioactivity of from 20,522 to 31,229 IU/mg and obtainable from a process for the purification of recombinant LH from a sample of crude recombinant LH in the supernatant of CHO cells which comprises the combined use of ion-exchange chromatography and reverse phase HPLC. The ion-exchange chromatography and the reverse phase HPLC are performed twice and the final use of a gel permeation column allows the purification from any residual traces of contaminants. The recombinant LH can be formulated into a pharmaceutical composition and used for treating a fertility disorder.
    Type: Application
    Filed: November 28, 2005
    Publication date: April 13, 2006
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Gianfranco Paradisi, Mara Rossi, Laura Scaglia
  • Publication number: 20030186893
    Abstract: A process for the purification of recombinant human Luteinizing Hormone (LH) from a sample of crude recombinant LH in the supernatant of CHO cells comprises the combined use of the ion-exchange chromatography and reverse phase HPLC. The ion-exchange chromatography and the reverse phase HPLC are performed twice and the final use of a gel permeation column allows the purification from any residual traces of contaminants. The specific bioactivity of the highly purified LH obtained from the process is particularly high, amounting to 25,000 IU/mg.
    Type: Application
    Filed: December 11, 2002
    Publication date: October 2, 2003
    Inventors: Gianfranco Paradisi, Mara Rossi, Laura Scaglia