Patents by Inventor Mara Sherman

Mara Sherman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INCREASING STORAGE OF VITAMIN A, VITAMIN D AND/OR LIPIDS
    Publication number: 20180325914
    Abstract: The present disclosure provides compositions that include a nanoparticle and a compound that reduces the biological activity of one or more bromodomain and extra-terminal family member (BET) proteins (e.g., a bromodomain inhibitor), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell.
    Type: Application
    Filed: May 18, 2018
    Publication date: November 15, 2018
    Applicant: Salk Institute for Biological Studies
    Inventors: Ronald M. Evans, Michael Downes, Mara Sherman, Ning Ding
  • VITAMIN D RECEPTOR AGONISTS TO TREAT DISEASES INVOLVING CXCL12 ACTIVITY
    Publication number: 20180200379
    Abstract: Provided herein are methods of treating pancreatic ductal adenocarcinoma in a mammalian subject. In some examples, such methods include administering a therapeutically effective amount of a VDR agonist (such as calcipotriol and/or paricalcitol) and administering a therapeutically effective amount of one or more chemotherapeutic agents, wherein the one or more chemotherapeutic agents comprise gemcitabine, 5-fluorouracil, cisplatin, protein-bound paclitaxel, and a PD-1 monoclonal antibody and/or PDL-1 monoclonal antibody.
    Type: Application
    Filed: February 19, 2018
    Publication date: July 19, 2018
    Applicant: Salk Institute for Biological Studies
    Inventors: Mara Sherman, Michael Downes, Ronald M. Evans
  • Vitamin D receptor agonists to treat diseases involving CXCL12 activity
    Patent number: 9895381
    Abstract: Provided herein are methods of treating and preventing pancreatitis, such as pancreatitis induced by glucagon-like peptide (GLP) agonists (such as GLP-1 agonists, for example Byetta®), by administration of a vitamin D receptor agonist (such as vitamin D, vitamin D analogs, vitamin D precursors, and vitamin D receptor agonists precursors). In some examples the subject has diabetes, such as type 2 diabetes.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: February 20, 2018
    Assignee: Salk Institute for Biological Studies
    Inventors: Mara Sherman, Michael Downes, Ronald M. Evans
  • INCREASING STORAGE OF VITAMIN A, VITAMIN D AND/OR LIPIDS
    Publication number: 20160331760
    Abstract: The present disclosure provides compositions that include a nanoparticle and a compound that reduces the biological activity of one or more bromodomain and extra-terminal family member (BET) proteins (e.g., a bromodomain inhibitor), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell.
    Type: Application
    Filed: August 2, 2016
    Publication date: November 17, 2016
    Applicant: Salk Institute for Biological Studies
    Inventors: Ronald M. Evans, Michael Downes, Mara Sherman, Ning Ding
  • VITAMIN D RECEPTOR AGONISTS TO TREAT DISEASES INVOLVING CXCL12 ACTIVITY
    Publication number: 20160089385
    Abstract: Provided herein are methods of treating and preventing pancreatitis, such as pancreatitis induced by glucagon-like peptide (GLP) agonists (such as GLP-1 agonists, for example Byetta®), by administration of a vitamin D receptor agonist (such as vitamin D, vitamin D analogs, vitamin D precursors, and vitamin D receptor agonists precursors). In some examples the subject has diabetes, such as type 2 diabetes.
    Type: Application
    Filed: December 4, 2015
    Publication date: March 31, 2016
    Applicant: Salk Institute for Biological Studies
    Inventors: Mara Sherman, Michael Downes, Ronald M. Evans