Abstract: Compounds, compositions, and methods for generating T cells with altered phenotype are disclosed. The phenotype-altered T cells have increased persistence, prolonged survival, and increased antitumor activity and are useful for treatment of cancers.

Abstract: Described herein are immunosuppressive molecules including immunosuppressive variants of IL-2, and use of such molecules to treat inflammatory and autoimmune disorders.

Abstract: Described herein are immunosuppressive molecules including immunosuppressive variants of IL-2, and use of such molecules to treat inflammatory and autoimmune disorders.

Abstract: Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.

Abstract: This disclosure is directed to compounds, compositions, and methods for the treatment of various diseases and/or conditions related to G protein-coupled receptor 174 (e.g., cancers).

Abstract: This disclosure provides systems for using failure mode ranking in an asset management system to generate asset maintenance outputs. Operational data, failure mode models, and configuration data for an asset, such as a complex electromechanical system, are related to failure prevention analytics configurations through failure mode rankings to enable the asset management system to reduce a future ranking of potential failure modes by changing the present configuration of the asset to include a recommended failure prevention analytics configuration.

Abstract: A dispatch optimization system leverages ambient and market forecast data as well as asset performance and parts-life models to generate recommended operating schedules for gas turbines or other power-generating plant assets that substantially maximize profit while satisfying parts-life constraints. The system generates operating profiles that balance optimal peak fire opportunities with optimal cold part-load opportunities within a maintenance interval or other operating horizon. During real-time operation of the assets, the optimization system can update the operating schedule based on actual market, ambient, and operating data. The system provides information that can assist operators in determining suitable conditions in which to cold part-load or peak-fire the assets in an optimally profitable manner without violating target life constraints.

Abstract: The present invention provides compositions and methods relating to antigen binding proteins against IL-21 receptor.

Abstract: Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.

Abstract: An architecture and techniques for determining operation of energy-producing equipment that can increase profitability are presented. Such can be surfaced in easily understood financial market paradigms that reflect relatively complex physical models associated with the equipment. For example, buy data and sell data can be presented that reflect determined buy opportunities and determined sell opportunities. The buy opportunities can represent conditions in which it is advised to operate the equipment according to a cold part load protocol and the sell opportunities can represent conditions in which it is advised to operate the equipment according to a peak fire protocol.

Abstract: A dispatch optimization system leverages ambient and market forecast data as well as asset performance and parts-life models to generate recommended operating schedules for gas turbines or other power-generating plant assets that substantially maximize profit while satisfying parts-life constraints. The system generates operating profiles that balance optimal peak fire opportunities with optimal cold part-load opportunities within a maintenance interval or other operating horizon. During real-time operation of the assets, the optimization system can update the operating schedule based on actual market, ambient, and operating data. The system provides information that can assist operators in determining suitable conditions in which to cold part-load or peak-fire the assets in an optimally profitable manner without violating target life constraints.

Abstract: Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.

Abstract: This disclosure provides systems for using failure mode ranking in an asset management system to generate asset maintenance outputs. Operational data, failure mode models, and configuration data for an asset, such as a complex electromechanical system, are related to failure prevention analytics configurations through failure mode rankings to enable the asset management system to reduce a future ranking of potential failure modes by changing the present configuration of the asset to include a recommended failure prevention analytics configuration.

Abstract: Described herein are immunosuppressive molecules including immunosuppressive variants of IL-2, and use of such molecules to treat inflammatory and autoimmune disorders.

Abstract: Described herein are immunosuppressive molecules including immunosuppressive variants of IL-2, and use of such molecules to treat inflammatory and autoimmune disorders.

Abstract: Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.

Abstract: Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.

Abstract: The present invention provides compositions and methods relating to antigen binding proteins against IL-21 receptor.

Abstract: The present invention provides compositions and methods relating to antigen binding proteins against IL-21 receptor.

Abstract: A system includes a controller configured to control one or more parameters of a gas turbine engine based on a feedback and a predicted lifespan of one or more components of the gas turbine engine to substantially maintain at least one of power output or heat rate above a threshold level in response to degradation or fouling of the gas turbine engine.