Abstract: Described herein are compositions and methods for the treatment or prevention of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious diseases of the anterior surface of the eye(s). Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.

Abstract: A method including inserting a plurality of images representing a real-world location to a user interface associated with an application configured to generate mixed reality content, associating an anchor with at least one of the plurality of images and associating an object with the anchor.

Abstract: Generally, abnormal pressures in the sinus cavity can have physiological effects due to stimulation or injury of various nerves that are in proximity to the sinus, including increased or decreased pressure on the nerves as well as extrusion of the nerves into the sinus cavities due to bony dehiscence. Methods and devices for alleviating disorders associated with the sinus cavities are described. Embodiments herein include diagnosing these disorders by occluding or restricting the sinus ostium and assessing the physiological effects caused by the occlusion/restriction and treating these disorders by navigating/directing a dilating device to the sinus ostium and dilating the sinus ostium. Other embodiments are directed to devices for maintaining the ostial opening.

Abstract: A method for performing a task in registration with a discrete seal in at least one material is described herein. The method involves simultaneously forming a discrete seal and a fiducial/eye mark in the at least one material. The method includes providing a detection device; providing a unit operation mechanism; and performing an operation on the material(s) in registration with the discrete seal. The task performed in registration with the discrete seal is based upon the location of the eye mark that was simultaneously formed with the discrete seal. A method of making flexible containers using cutting to form the outer periphery of the packages is described herein. Also described herein are flexible containers and container blanks made by such a method.

Abstract: Generally, abnormal pressures in the sinus cavity can have physiological effects due to stimulation or injury of various nerves that are in proximity to the sinus, including increased or decreased pressure on the nerves as well as extrusion of the nerves into the sinus cavities due to bony dehiscence. Methods and devices for alleviating disorders associated with the sinus cavities are described. Embodiments herein include diagnosing these disorders by occluding or restricting the sinus ostium and assessing the physiological effects caused by the occlusion/restriction and treating these disorders by navigating/directing a dilating device to the sinus ostium and dilating the sinus ostium. Other embodiments are directed to devices for maintaining the ostial opening.

Abstract: Generally, abnormal pressures in the sinus cavity can have physiological effects due to stimulation or injury of various nerves that are in proximity to the sinus, including increased or decreased pressure on the nerves as well as extrusion of the nerves into the sinus cavities due to bony dehiscence. Methods and devices for alleviating disorders associated with the sinus cavities are described. Embodiments herein include diagnosing these disorders by occluding or restricting the sinus ostium and assessing the physiological effects caused by the occlusion/restriction and treating these disorders by navigating/directing a dilating device to the sinus ostium and dilating the sinus ostium. Other embodiments are directed to devices for maintaining the ostial opening.

Abstract: The various embodiments described herein provide devices and methods for neuroablation in the tympanic cavity. Devices include an ablation effector that can be navigated into the tympanic cavity to ablate nerves therein in order to treat diseases caused due to the malfunction of these nerves.

Abstract: Generally, abnormal pressures in the sinus cavity can have physiological effects due to stimulation or injury of various nerves that are in proximity to the sinus, including increased or decreased pressure on the nerves as well as extrusion of the nerves into the sinus cavities due to bony dehiscence. Methods and devices for alleviating disorders associated with the sinus cavities are described. Embodiments herein include diagnosing these disorders by occluding or restricting the sinus ostium and assessing the physiological effects caused by the occlusion/restriction and treating these disorders by navigating/directing a dilating device to the sinus ostium and dilating the sinus ostium. Other embodiments are directed to devices for maintaining the ostial opening.

Abstract: Methods of making vents in containers made from flexible materials, including forming vent openings in a first flexible material, forming vent stand-offs on a second flexible material, and combining the flexible materials to form a vent passage for the flexible container.

Abstract: Apparatuses and methods for applying a transfer material onto one or more surfaces of an article are disclosed, including apparatuses and methods of transfer printing on and/or decorating three-dimensional articles, as well as the articles printed and/or decorated thereby. The apparatuses and methods may include providing a deposition device, such as a printing device; providing a transfer component; depositing a material onto a portion of the transfer component with the deposition device; modifying the portion of the transfer component with the transfer material thereon to conform the transfer component to at least a portion of one or more surfaces of the three-dimensional article; and transferring the transfer material onto the one or more surfaces of the article.

Abstract: A non-durable flexible container can include a first film wall including a first portion comprising at least one first structural support member defined in the first film wall, and a second portion that is free of a structural support member. The container can further include a second film wall including at least one second structural support member defined in the second film wall, wherein at least a portion of the first structural support member is adjacent to at least a portion of the second structural support member to define a seam region, and a side of the seam region defines an edge of the non-durable flexible container. The container can also include a closed produce volume defined between first and second film walls; and a seam projecting outwardly from the seam region at an intersection of the first and second film walls.

Abstract: A container blank having an article handling feature for handling the container blank as well as the flexible packages made therefrom during manufacture, and method of making flexible packages using such a feature are described herein. Also described herein is an array of flexible packages containing a common article handling feature provided by such a method.

Abstract: A method for performing a task in registration with a discrete seal in at least one material is described herein. The method involves simultaneously forming a discrete seal and a fiducial/eye mark in the at least one material. The method includes providing a detection device; providing a unit operation mechanism; and performing an operation on the material(s) in registration with the discrete seal. The task performed in registration with the discrete seal is based upon the location of the eye mark that was simultaneously formed with the discrete seal. A method of making flexible containers using cutting to form the outer periphery of the packages is described herein. Also described herein are flexible containers and container blanks made by such a method.

Abstract: Methods of making flexible containers that include structural support frames, including methods for sealing such containers.

Abstract: Non-durable self-supporting flexible containers with easily variable sizing. Line ups of flexible containers have similar sizes, shapes, and constructions, but hold differing amounts of fluent product at unexpected fill heights.

Abstract: Generally, abnormal pressures in the sinus cavity can have physiological effects due to stimulation or injury of various nerves that are in proximity to the sinus, including increased or decreased pressure on the nerves as well as extrusion of the nerves into the sinus cavities due to bony dehiscence. Methods and devices for alleviating disorders associated with the sinus cavities are described. Embodiments herein include diagnosing these disorders by occluding or restricting the sinus ostium and assessing the physiological effects caused by the occlusion/restriction and treating these disorders by navigating/directing a dilating device to the sinus ostium and dilating the sinus ostium. Other embodiments are directed to devices for maintaining the ostial opening.

Abstract: One embodiment provides a method, including: obtaining, using at least one sensor, a value related to a current overall power consumption for an electronic device; calculating, using a processor, a forecasted heat value calculated from the current overall power consumption, wherein the forecasted heat value indicates an expected value of heat for a region of the electronic device, wherein the calculating comprises correlating the current overall power consumption to a forecasted heat value; and proactively cooling, based upon a fan control algorithm, the electronic device prior to a sensor detecting a temperature corresponding to the expected value of heat, wherein the proactively cooling comprises adjusting a speed of one or more fans located within the electronic device based on the calculated heat value.

Abstract: In methods of making disposable, flexible containers for fluent products, methods of sealing the flexible containers when such containers include expansion materials, are disclosed. The methods include forming a partially completed container blank that has layers of flexible materials. The layered structure includes a first space for a fluent product, and a second space for an expansion material. The methods of sealing the flexible containers include adding an expansion material into the second space and pressing parts of at least some of the layers together to close off the second space.

Abstract: Apparatuses and methods for applying a transfer material onto one or more surfaces of an article are disclosed, including apparatuses and methods of transfer printing on and/or decorating three-dimensional articles, as well as the articles printed and/or decorated thereby. The apparatuses and methods may include providing a deposition device, such as a printing device; providing a transfer component; depositing a material onto a portion of the transfer component with the deposition device; modifying the portion of the transfer component with the transfer material thereon to conform the transfer component to at least a portion of one or more surfaces of the three-dimensional article; and transferring the transfer material onto the one or more surfaces of the article.