Patents by Inventor Marc Anthony Caporini

Marc Anthony Caporini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF KEY INTERMEDIATE OF KRAS G12C INHIBITOR COMPOUND
    Publication number: 20220220112
    Abstract: The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure useful for the synthesis of compounds that target KRAS G12C mutations, such as
    Type: Application
    Filed: March 8, 2022
    Publication date: July 14, 2022
    Inventors: Andrew Thomas PARSONS, Brian McNeil COCHRAN, William POWAZINIK, IV, Marc Anthony CAPORINI
  • Synthesis of key intermediate of KRAS G12C inhibitor compound
    Patent number: 11299491
    Abstract: The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure useful for the synthesis of compounds that target KRAS G12C mutations, such as
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: April 12, 2022
    Assignee: AMGEN INC.
    Inventors: Andrew Thomas Parsons, Brian McNeil Cochran, William Powazinik, IV, Marc Anthony Caporini
  • SYNTHESIS OF KEY INTERMEDIATE OF KRAS G12C INHIBITOR COMPOUND
    Publication number: 20200216446
    Abstract: The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure useful for the synthesis of compounds that target KRAS G12C mutations, such as
    Type: Application
    Filed: November 15, 2019
    Publication date: July 9, 2020
    Inventors: Andrew Thomas PARSONS, Brian McNeil COCHRAN, William POWAZINIK, IV, Marc Anthony CAPORINI
  • Method for NMR spectroscopy
    Patent number: 8963546
    Abstract: A method for performing magnetic resonance spectroscopy on solid samples containing nuclei of interest with spin quantum number I subjects the sample to a static magnetic field. The sample is spun at the magic angle and broad-band excitation of transverse magnetization of the nuclei of interest is effected by applying a first train of rotor-synchronized rf-pulses, having a carrier frequency, to the nuclei of interest with a pulse duration 0.1 ?s<?p<2 ?s, the first train of rf-pulses comprising k·n pulses extending over k rotor periods ?rot with n pulses per rotor period ?rot, wherein n is an integer n>1. Uniform excitation of a great number of spinning sidebands or families of sidebands that arise from large first-order quadrupole or hyperfine interactions is enabled and signal intensity is thereby improved.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: February 24, 2015
    Assignees: Bruker BioSpin AG, Ecole Polytechnique Fédéral de Lausanne (EPFL)
    Inventors: Simone Ulzega, Veronika Vitzthum, Geoffrey Bodenhausen, Marc Anthony Caporini
  • Method for NMR spectroscopy
    Publication number: 20120229137
    Abstract: A method for performing magnetic resonance spectroscopy on solid samples containing nuclei of interest with spin quantum number I subjects the sample to a static magnetic field. The sample is spun at the magic angle and broad-band excitation of transverse magnetization of the nuclei of interest is effected by applying a first train of rotor-synchronized rf-pulses, having a carrier frequency, to the nuclei of interest with a pulse duration 0.1 ?s<?p<2 ?s, the first train of rf-pulses comprising k·n pulses extending over k rotor periods ?rot with n pulses per rotor period ?rot, wherein n is an integer n>1. Uniform excitation of a great number of spinning sidebands or families of sidebands that arise from large first-order quadrupole or hyperfine interactions is enabled and signal intensity is thereby improved.
    Type: Application
    Filed: February 23, 2012
    Publication date: September 13, 2012
    Inventors: Simone Ulzega, Veronika Vitzthum, Geoffrey Bodenhausen, Marc Anthony Caporini